子宫肌瘤栓塞术(UFE)是有症状的子宫肌瘤的既定治疗方法。这项研究使用客观的磁共振成像(MRI)数据进行大小和灌注分析以及评估纤维瘤相关症状的患者问卷调查来评估UFE的功效。
患者在UFE前和第4天接受MR-血管造影检查,手术后6个月和12个月。使用专用软件评价图像。在UFE之前和随访12个月时完成患者问卷调查,集中于栓塞手术和与子宫肌瘤相关的症状。采用配对样本t检验和Wilcoxon符号秩检验对问卷进行统计分析,而Kruskal-Wallis试验和Friedman试验用于MRI分析。
其中包括11名女性。纤维瘤相关症状明显减轻。12个月后两者的体积减少都很显著,子宫和肌瘤,在第一次介入后MRI上子宫体积最初增加后。灌注分析表明,在UFE后12个月内,子宫肌瘤的血流量可以显着减少,而子宫组织则不受影响。
这项研究表明,子宫肌瘤栓塞导致肌瘤大小和灌注的长期显著减少,而健康的子宫组织不受影响。为了改善生活质量,减少了与纤维相关的症状。
Uterine fibroid embolisation (UFE) is an established treatment method for symptomatic uterine myomas. This study evaluates the efficacy of UFE using objective magnetic resonance imaging (MRI) data for size and perfusion analysis as well as patient questionnaires assessing fibroid-related symptoms.
Patients underwent MR-Angiography before UFE and 4 days, 6 and 12 months after the procedure. The images were evaluated using dedicated software. Patient questionnaires were completed before UFE and at 12 months follow-up, focussing on the embolization procedure and symptoms associated with uterine fibroids. Statistical analysis of the questionnaires was performed using paired sample t-test and Wilcoxon signed rank test, while Kruskal-Wallis test and Friedman test were applied for MRI-analysis.
Eleven women were included. There was a significant reduction in fibroid-related symptoms. The volume reduction after 12 months was significant in both, uterus and myomas, after an initial increase in uterine volume at the first post-interventional MRI. The perfusion analysis showed that blood flow to the fibroids could be significantly reduced up to 12 months after UFE while uterine tissue was not affected.
This study shows that uterine fibroid embolisation induces a significant long-term decrease in myoma size and perfusion while healthy uterine tissue remains unaffected. Fibroid-related symptoms are reduced for the sake of improved quality of life.