背景:植物性饮食具有许多健康益处,包括降低致命前列腺癌的风险,和更大的环境可持续性。然而,关于植物性饮食对前列腺癌患者生活质量的影响知之甚少.作者的目的是研究诊断后植物性饮食指数与生活质量之间的关系。
方法:这项前瞻性队列研究包括3505名健康专业人员随访研究(1986-2016)的非转移性前列腺癌参与者。食物频率问卷用于计算整体和健康的植物性饮食指数。使用扩展前列腺癌综合指数计算生活质量评分。使用广义估计方程来检查基于植物的饮食指数与生活质量领域(性功能,泌尿刺激/阻塞,尿失禁,肠道功能,荷尔蒙/活力),根据人口统计进行调整,肿瘤病史,身体质量指数,热量摄入,与健康相关的行为,和合并症。
结果:前列腺癌诊断的中位年龄为68岁;48%的患者接受了根治性前列腺切除术,35%接受放疗作为主要治疗。从诊断/治疗到首次使用生活质量问卷的中位时间为7.0年。较高的植物性饮食指数与较好的性功能评分相关,泌尿刺激/阻塞,尿失禁,和荷尔蒙/活力。食用更健康的植物性食物也与更好的性功能和肠道功能有关。以及年龄调整分析中的尿失禁和荷尔蒙/活力评分,但不是在多变量分析中。
结论:这项前瞻性研究提供了支持性证据,表明更多的健康植物性食物与前列腺癌患者的生活质量方面得分更高相关。
BACKGROUND: Plant-based diets have many health benefits, including a lower risk of fatal prostate cancer, and greater environmental sustainability. However, less is known regarding the impact of plant-based diets on quality of life among individuals diagnosed with prostate cancer. The authors\' objective was to examine the relationship between plant-based diet indices postdiagnosis with quality of life.
METHODS: This prospective cohort study included 3505 participants in the Health Professionals Follow-Up Study (1986-2016) with nonmetastatic prostate cancer. Food-frequency questionnaires were used to calculate overall and healthful plant-based diet indices. Quality-of-life scores were calculated using the Expanded Prostate Cancer Index Composite. Generalized estimating equations were used to examine associations over time between plant-based diet indices and quality-of-life domains (sexual functioning, urinary irritation/obstruction, urinary incontinence, bowel functioning, hormonal/vitality), adjusted for demographics, oncologic history, body mass index, caloric intake, health-related behaviors, and comorbidities.
RESULTS: The median age at prostate cancer diagnosis was 68 years; 48% of patients underwent radical prostatectomy, and 35% received radiation as primary therapy. The median time from diagnosis/treatment to first the quality-of-life questionnaire was 7.0 years. A higher plant-based diet index was associated with better scores for sexual function, urinary irritation/obstruction, urinary incontinence, and hormonal/vitality. Consuming more healthful plant-based foods was also associated with better sexual and bowel function, as well as urinary incontinence and hormonal/vitality scores in the age-adjusted analysis, but not in the multivariable analysis.
CONCLUSIONS: This prospective study provides supportive evidence that greater consumption of healthful plant-based foods is associated with modestly higher scores in quality-of-life domains among patients with prostate cancer.