urethral stenosis

  • 文章类型: Case Reports
    我们报告了一例下尿路症状(LUTS)的经会阴前列腺双极切除术(TPR-P)。据我们所知,这是科学文献中的第一个描述。2015年,一名67岁的男子因严重的Fournier坏疽发作而有多次阴茎清创和形成会阴造口术的病史,因急性尿潴留而被送往急诊室。连续,插入耻骨上导管.由于延髓狭窄和前列腺尿道梗阻,导管插入的尝试失败。在通过扩张球狭窄消退后,排尿后残余体积持续高达150毫升。TPR-P术后的过程顺利。无不良事件发生。六周后的评估显示,症状的国际前列腺症状评分(IPSS)改善近50%,总体满意度>60%(术前:IPSS:S=24,L=6;术后IPSS:S=13,L=2)。排尿后的平均残余体积从术前的150ml减少到术后的15ml(范围0-30ml)。由于尿道全长缺失,对于我们手中的经典切除技术来说,增加的运动范围似乎太宽松了。因此,我们认为,在这种情况下,使用摘除技术可能是有利的。然而,在我们的案例中,TPR-P是可行和安全的,具有良好的功能效果。
    We report a case of transperineostomal bipolar resection of the prostate (TPR-P) for lower urinary tract symptoms (LUTS). To our knowledge, this is the first description in the scientific literature. A 67-year-old man with a medical history of multiple penile debridements and formation of a perineostomy due to an episode of severe Fournier\'s gangrene in 2015, was admitted to the emergency room with acute urinary retention. Consecutively, a suprapubic catheter was inserted. Attempts of catheterization failed due to bulbar stenosis and an obstructive prostatic urethra. After the resolution by dilatation of the bulbar stenosis, post-voiding residual volume persisted at up to 150 ml. The intra- and postoperative course after TPR-P was uneventful. No adverse events occurred. The assessment after six weeks revealed an International Prostate Symptom Score (IPSS) improvement of nearly 50% for the symptoms and >60% for overall satisfaction (preoperative: IPSS: S=24, L=6; postoperative IPSS: S=13, L=2). The average post-voiding residual volume decreased from 150 ml preoperatively to 15 ml (range 0-30 ml) postoperatively. Due to the missing full length of the urethra, the augmented range of motion seemed almost too loose for classic resection techniques in our hands. Therefore, we believe that in such cases it might be advantageous to use enucleation techniques. However, in our case, TPR-P was feasible and safe with a good functional outcome.
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  • 文章类型: Case Reports
    据报道,在机器人辅助腹腔镜前列腺癌根治术(RARP)开始时无法留置尿道导管。一名64岁的男子因诊断为前列腺癌cT2aN0M0而因RARP入院。在RARP开始的时候,通过插入尿道导管形成假尿道,所以手术开始于经腹后入路,没有留置尿道导管。膀胱颈切除术时打开尿道,一根导丝被顺次插入,尿道逆行扩张,留置了一根尿道导管。之后,手术照常进行,手术完成了。当在RARP开始时尿道导管无法留置时,在手术期间可以使用顺行方法来做到这一点。
    A case in which a urethral catheter could not be indwelled at the start of robot-assisted laparoscopic radical prostatectomy (RARP) is reported. A 64-year-old man was admitted to the hospital for RARP with a diagnosis of prostate cancer cT2aN0M0. At the start of RARP, a pseudo-urethra was formed by inserting a urethral catheter, so surgery was started with a transabdominal posterior approach without indwelling the urethral catheter. The urethra was opened during bladder neck resection, a guide wire was inserted anterogradely, the urethra was dilated retrogradely, and a urethral catheter was indwelled. After that, the procedure was performed as usual, and the operation was completed. When the urethral catheter could not be indwelled at the start of RARP, it was possible to do so using an anterograde approach during the operation.
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  • 文章类型: Case Reports
    尿路联合气管瘘是一种罕见的破坏性并发症,在前列腺癌的放射治疗后发展,通常由辐射引起的尿道狭窄的治疗引发。这里,我们报告了我们在3例前列腺癌患者中使用尿道联合瘘的经验。
    3例前列腺癌患者在放疗后出现尿道狭窄。在病例1中,尿道狭窄的治疗方法是耻骨上置管,在病例2中,直视尿道内切开术,在病例3中,切除并进行原发性吻合术。所有患者均出现严重的耻骨上或大腿疼痛或两者兼有。在磁共振成像中检测到了尿道裂瘘。保守治疗不成功,所有患者均需清除坏死耻骨联合和单纯膀胱切除术。在病例1和2中,进行了回肠导管尿流改道。
    泌尿科医师需要意识到,在接受照射的前列腺癌患者中可能会发生尿道联合瘘,尤其是尿道狭窄治疗后。
    UNASSIGNED: Urosymphyseal fistula is a rare and devastating complication that develops after radiation therapy for prostate cancer and is often triggered by the treatment of radiation-induced urethral stenosis. Here, we report our experience with urosymphyseal fistulas in three patients with prostate cancer.
    UNASSIGNED: Three patients with prostate cancer developed urethral stenosis after radiotherapy. The management of urethral stenosis was suprapubic tube placement in case 1, direct vision internal urethrotomy in case 2, and excision with primary anastomosis in case 3. All patients presented with severe suprapubic or thigh pain or both. Urosymphyseal fistulas were detected on magnetic resonance imaging. Conservative treatment was unsuccessful, and all patients required debridement of the necrotic pubic symphysis and simple cystectomy. In cases 1 and 2, ileal conduit urinary diversion was performed.
    UNASSIGNED: Urologists need to be aware that urosymphyseal fistulas can occur in irradiated patients with prostate cancer, especially after urethral stenosis treatment.
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  • 文章类型: English Abstract
    Posterior urethritis is diagnosed in prepubertal or pubertal boys mainly with terminal asymptomatic haematuria or postmicturition blood spotting on the meatus or in the underwear. It presents with typical changes in the bulbar urethra (hyperaemia, oedema and denuded mucosa) without laboratory or radiological findings. The pathology is self-limiting with a very good prognosis. This condition is most likely caused by dysfunctional voiding and urotherapy with biofeedback therapy offers good treatment results. Although urethrocystoscopy is the only way to confirm the diagnosis, the patient should be prevented from having a (usually unnecessary) urethrocystoscopy and the relatives should be reassured.
    UNASSIGNED: Von einer Urethritis posterior wird bei präpubertären bzw. pubertären Jungen mit meist terminaler asymptomatischer Hämaturie, oft mit postmiktionellen Blutspuren am Meatus oder in der Unterwäsche, gesprochen. Es stellen sich dabei typische Veränderungen in der bulbären Harnröhre dar, ohne dass ein labortechnischer oder radiologischer Befund vorliegt. Die Pathologie ist selbstlimitierend mit einer sehr guten Prognose und stellt eine Ausschlussdiagnose dar. Diese Erkrankung wird am ehesten durch ein „dysfunctional voiding“ verursacht und eine Urotherapie mit Biofeedback-gestütztem Miktionstraining bietet gute Behandlungsergebnisse. Auch wenn die Urethrozystoskopie die einzige Möglichkeit ist, die Diagnose zu bestätigen, sollte man den Jungen vor einer (meist unnötigen) Urethrozystoskopie bewahren und die Angehörigen beruhigen.
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  • 文章类型: Case Reports
    我们介绍了一个6岁女孩的案例,该女孩在排尿流中出现了变化。在体检时,一个非常小的尿道口是以牺牲膜为代价的。翻新超声检查未显示任何变化。进行了尿流测量研究,显示膀胱出口阻塞模式。校准尿道口并进行腹侧切开术。切除膜的组织学研究显示,移行性尿道粘膜伴有慢性局灶性炎症和离散增生。病人进化良好,症状缓解,无明显并发症。这是,据我们所知,首次报道了先天性尿道狭窄的组织学研究。在下尿路梗阻的情况下,在鉴别诊断中应该考虑这个实体.手术治疗是有疗效的。
    We present the case of a 6-year-old girl who presented with alterations in the voiding stream. On physical examination, a very small urethral meatus was identified at the expense of a membrane. The renovesical ultrasound showed no alterations. An uroflowmetric study was performed, showing a bladder outlet obstruction pattern. The urethral meatus was calibrated and a ventral meatotomy was performed. The histological study of the resected membrane showed a transitional urethral mucosa with chronic focal inflammation and discrete hyperplasia. The patient evolved favorably, with resolution of the symptoms and no notable complications. This is, to the best of our knowledge, the first reported case with a histological study of a congenital meatal urethral stenosis. In the presence of lower urinary tract obstruction, this entity should be considered in the differential diagnosis. Surgical treatment is curative.
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  • 文章类型: Journal Article
    目的:分析因前列腺癌治疗引起的球膜尿道狭窄/狭窄(RIS)而接受吻合口尿道成形术的患者,随访长达19年,并评估患者报告的长期结局(PROMs)。在现有的研究中,缺乏包含尿道成形术特定PROM的长期随访。
    方法:从2002年到2020年,确定了接受吻合口尿道成形术治疗RIS的患者。纳入标准包括完成术后4个月的膀胱镜检查和包括IPSS在内的PROM,SHIM,MSHQ-EF,6Q-LUTS,以及4个月时的全球满意度查询。此后,每年对PROM进行评估,并对PROM的不良变化或尿流/PVR参数恶化进行膀胱镜检查。PROM在术前进行了比较,术后,以及最近的后续行动。
    结果:23例患者符合纳入标准。短期解剖成功率为95.7%。平均随访73.1个月(9.1-228.9),1次晚期复发,总成功率为91.3%.在排尿分数中确定了显著和持续的客观改善,生活质量,和尿道成形术特定的PROM。尽管存在性副作用,满意度为91.3%,95.7%的患者表示,在平均6年以上的随访中,他们会在知道结果的情况下再次接受手术。
    结论:RIS是具有挑战性的问题,但经过精心挑选的患者可实现持久的症状缓解。应就吻合口尿道成形术后尿失禁和性副作用的风险对患有鼓膜RIS的患者进行适当咨询。然而,长期成功很高,在大多数情况下,总体QoL将有持续的主观改善。
    OBJECTIVE: To analyze patients who underwent anastomotic urethroplasty for radiationinduced bulbomembranous urethral stricture/stenosis (RIS) due to prostate cancer treatment with up to 19 years of follow-up and assess long-term patient reported outcomes (PROMs). Long-term follow-up with the inclusion of urethroplasty specific PROMs is lacking in the available research.
    METHODS: Patients who underwent anastomotic urethroplasty for RIS were identified from 2002 to 2020. Inclusion criteria included completion of 4-month post-operative cystoscopy and PROMs including IPSS, SHIM, MSHQ-EF, 6Q-LUTS, and global satisfaction queries at 4 months. PROMs were assessed annually thereafter, and cystoscopy was performed for adverse change in PROMs or worsening uroflow/PVR parameters. PROMs were compared at pre-op, post-op, and most recent follow-up.
    RESULTS: 23 patients met inclusion criteria. Short-term anatomic success was 95.7%. At a mean follow-up of 73.1 months (9.1-228.9), one late recurrence occurred for an overall success of 91.3%. Significant and sustained objective improvement was identified in voiding scores, quality of life, and urethroplasty specific PROMs. Satisfaction was 91.3% despite sexual side effects, and 95.7% of patients stated they would have surgery again knowing their outcome at a mean of over 6 years\' follow up.
    CONCLUSIONS: RIS are challenging problems, but durable symptomatic relief is achievable in well-selected patients. Patients with bulbomembranous RIS should be appropriately counseled regarding the risk of urinary incontinence and sexual side effects after anastomotic urethroplasty. However, long-term success is high, and overall QoL will have sustained subjective improvement in most cases.
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  • 文章类型: Journal Article
    尿道膀胱造影仍然是尿道病理诊断的金标准技术。如今,在进行尿道膀胱造影的各种适应症中,最常见的是由于临床怀疑尿道狭窄。由于狭窄的高患病率及其对患者生活质量的实质性影响,检查必须允许位置,排除多焦点,并评估狭窄程度以影响手术计划。本文旨在证明放射科医生的作用,通过执行和解释尿道膀胱造影的方式,影响并对泌尿外科治疗决策至关重要,并且接受尿道成形术重建的患者成功率更高。作者旨在回顾男性尿道的放射学解剖学,讨论尿道成像的选择方式(逆行尿道造影和排尿膀胱尿道造影),提供进行研究的不同适应症的概述,检查尿道狭窄的不同病因,了解尿道病理的不同表现的相关性,并确定手术选择,尤其是尿道狭窄的治疗。同时,这项研究揭露了尿道创伤的病例,瘘管,憩室,和先天性异常。
    Urethrocystography remains the gold-standard technique for urethral pathology diagnosis. Nowadays, of the various indications for performing urethrocystography, the most common is due to a clinical suspicion of urethral stricture. Due to the high prevalence of strictures and their substantial impact on a patient\'s quality of life, the examination must allow the location, exclusion of multifocality, and assessment of the extent of the stricture to influence surgical planning. This article intends to demonstrate that the radiologist\'s role, by performing and interpreting the modality of urethrocystography, influences and is crucial for the urologic therapeutic decision and that the patients who were submitted to reconstruction by urethroplasty had a better success rate. The authors aim to review the radiological anatomy of the male urethra, discuss the modalities of choice for imaging the urethra (retrograde urethrography and voiding cystourethrography), provide an overview of the different indications for performing the study, examine the different etiologies for urethral strictures, understand the relevance of the different appearances of urethral pathology, and identify the surgical options, especially in the treatment of urethral strictures. Simultaneously, the study exposes cases of urethral trauma, fistulas, diverticulum, and congenital abnormalities.
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  • 文章类型: Journal Article
    目的:骨盆骨折尿道损伤引起的尿道狭窄(PFUI)是一种复杂的泌尿系统疾病,特别是对于重做。然而,找到后尿道的近端,避免损伤直肠和预测切除耻骨下缘是手术成功的两个关键点。即使是最有经验的泌尿科医师,这些步骤也可能具有挑战性。这项研究是为了描述一种新的技术,以了解尿道的三维(3D)解剖结构,这也将有助于手术计划和简化尿道成形术。
    方法:3例患者接受常规尿道镜检查,X线尿道造影与CT尿道造影。然后重建了3D图像,数据被传输到3D打印机。用聚丙烯酸3D打印模型,以模拟尿道狭窄与耻骨联合和直肠的解剖结构和关系。将各种诊断方法与手术条件进行比较。对患者和学员进行问卷调查。
    结果:获得3个尿道CT模型。这些模型与常规尿道镜检查一起提供给患者和实习医生,尿道造影,尿道CT.患者和学员问题表的评分表明,3D打印的骨盆骨折尿道狭窄模型在尿道邻接和易于理解方面具有明显的优势。3D打印尿道很容易显示耻骨联合,并模拟其切除和暴露尿道。该模型可以显示尿道到直肠的精确距离,以防止手术中直肠损伤。
    结论:3D打印技术可应用于PFUI所致尿道狭窄的术前评估。它可以辅助了解后尿道的解剖结构,尿道移位的方向,直肠保护和前列腺切除术的预测。对于一些复杂的尿道狭窄和重做病例的准确术前规划尤其有帮助。
    OBJECTIVE: Urethral stenosis caused by pelvic fracture urethral injury (PFUI) is a complex urological disease, especially for the redo cased. However, to find the proximal end of the posterior urethra, and to avoid injury to the rectum and to forecast to remove the inferior pubic margin are two key points for a successful surgery. These steps can be challenging for even the most experienced urologists. This study is to describe a new technique for understanding the three-dimensional (3D) anatomy of the urethra, which will also aid in surgical planning and simplify urethroplasty.
    METHODS: Three patients underwent routine urethroscopy, X ray urethrography and contrast CT urethrography. The 3D images were then reconstructed, and the data were transmitted to a 3D printer. 3D models were printed with polyacrylic acid to simulate the anatomical structure and relationship of urethral stenosis with pubic symphysis and rectum. Various diagnosis methods were compared with the condition in surgery. The patients and trainee questionnaires were performed.
    RESULTS: Three models of urethral CT were obtained. These models were presented to patients and trainee doctors along with routine urethroscopy, urethrography, and urethral CT. The scores of patients and trainee question forms demonstrated that the 3D printed urethral stenosis model of pelvic fracture has obvious advantages in urethral adjacency and ease of understanding. The 3D printed urethras were easy to show the pubic symphysis and simulate its excision and exposure of urethra. The model could show the precise distance from urethra to rectum to prevent the rectum injury in surgery.
    CONCLUSIONS: 3D printing technology can be applied to the preoperative evaluation of urethral stenosis caused by PFUI. It can be auxiliary to understand the anatomical structure of the posterior urethra, the direction of urethral displacement, protecting the rectum and the forecasting for pubectomy. It is especially helpful for the accurate preoperative planning of some complex urethral stenosis and redo cases.
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  • 文章类型: Journal Article
    尿道狭窄疾病是一种非常异质的疾病,由于各种病因,预后不同,可能涉及不同的尿道段。尿道狭窄的外科治疗,特别是尿道成形术可以在许多层面上导致非常不同的结果,目前,对于尿道手术后什么应该和什么不应该被认为是“成功”,绝对没有共识。在泌尿外科肿瘤学建立完善的质量标准之后,例如三餐或五餐的结果,鉴于尿道手术后对有意义的结果缺乏共识,我们的目标是介绍我们的研究方案,作为多步骤研究的第一步,目的是在一个新的概念框架内就尿道成形术的综合结局达成共识:“狭窄-fecta标准”。狭窄-fecta的发展将基于Delphi共识,该共识涉及一些全球影响最大的重建泌尿科医师。
    Urethral stricture disease is a very heterogeneous condition where different urethral segments can be involved as a result of diverse etiologies which come with variable prognosis. The surgical management of urethral strictures, and in particular urethroplasties can result in very diverse outcomes on many levels and, currently, there is absolutely no consensus about what should and what should not be considered a \"success\" after urethral surgery. In the wake of well-established quality criteria in urologic oncology, such as tri- or pentafecta outcomes, and given the lack of agreement on meaningful outcomes after urethral surgery, we aim to introduce our study protocol as the first step of a multistep research endeavor to reach consensus on comprehensive urethroplasty outcomes within a novel conceptual framework: the \"stricture-fecta criteria\". The development of stricture-fecta will be based on a Delphi consensus involving some of worldwide most influencing reconstructive urologists.
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  • 文章类型: Journal Article
    目的:我们旨在对现有的诊断指南进行全面的比较审查,管理,美国泌尿外科协会(2016年)对后尿道狭窄患者进行了随访,国际社会(2010),和欧洲泌尿外科协会(2022年)。
    方法:AUA,SIU,和EAU指南评估了诊断建议,评估,后尿道狭窄的治疗。我们还纳入了EAU和AUA泌尿系创伤相关狭窄的指南。在指南之间存在差异的情况下,包括建议的水平或强度。
    结果:这三项指南在为诊断提供的建议中相当一致,管理,并对后尿道狭窄患者进行随访。与AUA相比,SIU和EAU强调了重复内镜治疗在指南中的作用。
    结论:放射治疗后修复球膜狭窄/狭窄的首选方法仍然是一个活跃的领域,专注于节制保存。此外,在有或没有辅助治疗的情况下,先进的内窥镜治疗可能会发挥作用,以管理甚至消失的狭窄。
    OBJECTIVE: We aimed to provide a thorough comparative review of the available guidelines on the diagnosis, management, and follow-up for patients with posterior urethral stenosis by the American Urologic Association (2016), Société Internationale d\'Urologie (2010), and European Urologic Association (2022).
    METHODS: The AUA, SIU, and EAU guidelines were evaluated for recommendations on the diagnosis, evaluation, and treatment of posterior urethral stenosis. We also included the EAU and AUA urologic trauma guidelines for the trauma-related stenosis. The level or strength of recommendations is included in case of disparity between the guidelines.
    RESULTS: The three guidelines align considerably in recommendations provided for the diagnosis, management, and follow-up of patients with posterior urethral stenosis. SIU and EAU emphasize the role of repeat endoscopic treatment in guidelines compared to AUA.
    CONCLUSIONS: The preferred method to repair bulbo-membranous stricture/stenosis following radiation therapy remains an area of active interest, focusing on continence preservation. Additionally, there may be a role for advanced endoscopic treatments with or without adjunct therapies to manage even obliterated stenoses.
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