ureteral stenosis

  • 文章类型: Journal Article
    目的:本研究旨在探讨输尿管镜辅助腹腔镜输尿管成形术治疗盆腔术后输尿管狭窄的安全性和有效性。
    方法:回顾性分析2017年6月至2023年3月赣州市人民医院行盆腔手术治疗的95例输尿管狭窄患者的临床资料。在这个群体中,49例患者在截石位下行输尿管镜及腹腔镜输尿管成形术。对照组包括46例仰卧位进行简单腹腔镜输尿管成形术的患者。收集并比较两组患者术后数据,包括操作时间,手术过程中的失血量,术后住院时间,并发症的发生率,输尿管成形术的成功率,和操作的有效性。
    结果:观察组端端端输尿管吻合成功率为93.88%,手术有效率为100%。对照组手术成功率为78.26%,手术有效率为89.1%。观察组平均手术时间和术中出血量分别为(121.3±44.6)min和(137.5±34.2)ml,分别,对照组分别为(151.2±52.3)min和(165.6±45.8)ml,差异有统计学意义(P<0.05)。观察组围手术期并发症发生率为2%,显著低于对照组(19.6%)(P<0.05)。
    结论:输尿管镜辅助腹腔镜输尿管成形术治疗盆腔术后输尿管狭窄具有缩短手术时间的优点。成功率提高,减少并发症的发生率,使其成为临床实践中的可选手术方案。
    OBJECTIVE: This study is to investigate the safety and efficacy of ureteroscope-assisted laparoscopic ureteroplasty in treating ureteral stricture after pelvic surgery.
    METHODS: A retrospective analysis of the clinical data of 95 patients treated for ureteral stricture at Ganzhou People\'s Hospital from June 2017 to March 2023 after pelvic surgery. In this group, 49 patients underwent ureteroscope and laparoscopic ureteroplasty under lithotomy position. The control group consisted of 46 patients who underwent simple laparoscopic ureteroplasty in a supine position. Postoperative data from both groups were collected and compared, including operation time, amount of blood loss during surgery, postoperative hospital stay, incidence of complications, success rate of ureteroplasty, and effectiveness of the operation.
    RESULTS: The success rate of end-to-end ureteral anastomosis in the observation group was 93.88%, and the operation effectiveness rate was 100%. The success rate in the control group was 78.26% and the operation effectiveness rate was 89.1%.The average operation time and intraoperative blood loss in the observation group were (121.3 ± 44.6) min and (137.5 ± 34.2) ml, respectively, while in the control group they were (151.2 ± 52.3) min and (165.6 ± 45.8) ml, the difference were statistically significant (P < 0.05). The incidence of perioperative complications in the observation group was 2%, significantly lower than that in the control group (19.6%) (P < 0.05).
    CONCLUSIONS: Ureteroscope-assisted laparoscopic ureteroplasty for ureteral stricture after pelvic surgery has the advantages of shortened operation time, increased success rate, and reduced incidence of complications, making it an optional surgical scheme in clinical practice.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    急性移植肾盂肾炎(AGPN)是肾移植(KTs)中相对常见的并发症;然而,对同种异体移植功能的影响,诊断标准,和风险因素没有很好地确定。
    在2011年1月1日至2018年12月31日期间对所有连续成年KT进行回顾性分析(随访于2019年12月31日结束),以检查移植后第一年的AGPN诊断(经磁共振成像[MRI]证实)与移植物结局之间的关系。
    在939个连续的KT中(捐献者≥60岁时约为50%),我们确定了130次MRI证实的AGPN发作,与复发性和多药耐药细菌性尿路感染(UTI)相关(p<0.005)。输尿管狭窄是与AGPN相关的唯一危险因素(OR2.9[95%CI,1.6-5.2])。使用AGPN的KT在第一年的同种异体移植功能降低(非AGPN的ΔeGFR6mL/min/1.73m2[-2-15]与-0.2[-6.5-8.5]在AGPN中,p<0.001),来自标准或老年捐赠者的KT具有相似和负面的特征。然而,只有AGPN和供体<60岁的KT显示死亡审查移植物存活率降低(p=0.015);该亚组中的大多数接受了抗胸腺细胞球蛋白(ATG)诱导(40.4%vs.17.7%),他们的MRI表现为多焦AGPN模式(73.9%vs.56.7%)或脓肿(28.3%与11.7%)。早期(KT后<3个月)或晚期(3-12个月)AGPN之间的死亡审查移植物存活率没有差异,孤立/复发形式,或多药耐药病原体的类型。线性回归证实了多焦点模式的独立作用,脓肿,ATG感应,和捐赠者的年龄在第一年的eGFR。
    AGPN,受到多焦点呈现的影响,ATG感应,供体年龄,和脓肿,影响肾功能,并显着影响供体<60岁的KT的同种异体移植存活率。
    UNASSIGNED: Acute graft pyelonephritis (AGPN) is a relatively common complication in kidney transplants (KTs); however, the effects on allograft function, diagnostic criteria, and risk factors are not well established.
    UNASSIGNED: Retrospective analysis of all consecutive adult KTs was performed between 01 January 2011 and 31 December 2018 (follow-up ended on 31 December 2019) to examine the association between the diagnosis of AGPN (confirmed with magnetic resonance imaging [MRI]) during the first post-transplantation year and graft outcomes.
    UNASSIGNED: Among the 939 consecutive KTs (≈50% with donors ≥60 years), we identified 130 MRI-confirmed AGPN episodes, with a documented association with recurrent and multidrug-resistant bacterial urinary tract infections (UTIs) (p < 0.005). Ureteral stenosis was the only risk factor associated with AGPN (OR 2.9 [95% CI, 1.6 to 5.2]). KTs with AGPN had a decreased allograft function at the first year (ΔeGFR 6 mL/min/1.73 m2 [-2-15] in non-AGPN vs. -0.2 [-6.5-8.5] in AGPN, p < 0.001), with similar and negative profiles in KTs from standard or elderly donors. However, only KTs with AGPN and a donor <60 years showed reduced death-censored graft survival (p = 0.015); most of this subgroup received anti-thymocyte globulin (ATG) induction (40.4% vs. 17.7%), and their MRI presented either a multifocal AGPN pattern (73.9% vs. 56.7%) or abscedation (28.3% vs. 11.7%). No difference was noted in death-censored graft survival between early (<3 months post-KT) or late (3-12 months) AGPN, solitary/recurrent forms, or types of multidrug-resistant pathogens. Linear regression confirmed the independent role of multifocal pattern, abscedation, ATG induction, and donor age on the eGFR at the first year.
    UNASSIGNED: AGPN, influenced by multifocal presentation, ATG induction, donor age, and abscedation, affects kidney function and significantly impacts allograft survival in KTs with donors <60 years.
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  • 文章类型: Case Reports
    移植输尿管狭窄(US)是肾移植(KT)的并发症,有时会对肾功能产生不利影响。内窥镜治疗可以选择作为初始治疗;然而,复发率高。输尿管重建作为二次治疗是必要的,但是由于再次手术,通常很难识别移植的输尿管;因此,移植输尿管和肾动静脉损伤是术中应注意的并发症。近红外射线导管(NIRC™)荧光输尿管导管(NIRFUC)通过照射近红外射线发出荧光,有助于确定术中输尿管位置。在这里,我们报道了一例34岁女性KT后发展为US的病例.她接受了美国移植的气球扩张术,但狭窄复发;因此,她接受了移植输尿管自动输尿管吻合术。尽管由于粘连,很难识别和分离移植的输尿管,NIRFUC的使用有助于识别手术区域中的输尿管,并实现了移植输尿管和自体输尿管之间的安全端侧吻合.总之,尽管对于复杂的美国移植相关病例的最佳方法尚未达成共识,NIRFUC可用于安全地识别和在输尿管上进行手术。
    Transplant ureteral stenosis (US) is a complication of kidney transplantation (KT) that sometimes adversely affects kidney function. Endoscopic treatment may be selected as the initial treatment; however, the recurrence rate is high. Ureteral reconstruction is necessary as a secondary treatment, but it is often difficult to identify the transplanted ureter due to reoperation; therefore, transplanted ureter and renal arteriovenous injury are intraoperative complications that should be noted. The Near-Infrared Ray Catheter (NIRC™) fluorescent ureteral catheter (NIRFUC) fluoresces by illuminating near-infrared rays, facilitating the identification of intraoperative ureteral locations. Herein, we report the case of a 34-year-old woman who developed US following KT. She underwent balloon dilation for transplant US, but the stenosis recurred; therefore, she underwent transplant ureteral auto-ureteral anastomosis. Although it was difficult to identify and detach the transplanted ureter owing to adhesions, the use of NIRFUC facilitated the identification of the ureter in the surgical field and enabled safe end-side anastomosis between the transplanted ureter and the autologous ureter. In conclusion, although there is no consensus on the best method for complex transplantation-related US cases, NIRFUC may be used to safely identify and perform surgeries on the ureter.
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  • 文章类型: Journal Article
    作者描述了他们使用机器人辅助颊粘膜移植物(BMG)输尿管成形术治疗近端输尿管狭窄的初步经验。
    The authors describe their initial experience with robot-assisted buccal mucosal graft (BMG) ureteroplasty for the management of proximal ureteral strictures.
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  • 文章类型: Case Reports
    背景:处理输尿管狭窄的常规方法包括放置双J支架。近年来,使用Allium输尿管支架(URS)已成为治疗输尿管狭窄的一种新方法。与传统支架相比,葱属URS有几个优点,包括延长留置时间和减少并发症的发生率。目前,全球报告的使用葱属URS治疗输尿管狭窄的病例数量有限。在本文中,我们介绍一例67岁患者使用AlliumURS治疗回肠-输尿管吻合口狭窄的病例详情.我们的目标是评估在这种情况下使用AlliumURS的可行性。
    方法:一名67岁的中国妇女因左侧腰痛转诊到我院治疗。尿路造影显示左回肠输尿管吻合口狭窄。计算机断层扫描(CT)显示左肾严重肾积水。随后,通过输尿管镜检查植入了AlliumURS。我们没有发现血尿,随访期间腰痛或尿路刺激。8个月后,病人因左腰痛再次入院。CT复查提示左侧肾积水轻度好转。AlliumURS已经脱离并在其表面上显示出石头形成。为了进一步治疗,进行了输尿管镜检查,并植入了新的AlliumURS。在3个月的随访中,CT复查显示支架再次移位,但左肾肾积水明显改善。膀胱镜检查显示支架已完全脱离,并且壁结石已附着在该表面上。通过膀胱镜取下支架。一个月后,CT扫描显示患者左侧肾积水几乎消失。
    结论:AlliumURS治疗回肠输尿管吻合口狭窄所致肾积水有效。虽然并发症,如血尿,腰痛和尿路刺激,是罕见的,并发症,如支架移位和结石形成,可能发生。因此,在考虑使用AlliumURS治疗回肠-输尿管吻合口狭窄的患者时,必须谨慎行事。
    BACKGROUND: The conventional approach for managing ureteral stenosis involves the placement of a double-J stent. In recent years, the utilisation of Allium ureteral stent (URS) has emerged as a novel treatment alternative for ureteral stenosis. Allium URS has several advantages over traditional stents, including an extended indwelling time and reduced incidence of complications. The number of cases reported worldwide on the use of Allium URS in the treatment of ureteral stenosis is currently limited. In this paper, we present the details of a case involving the use of an Allium URS to treat ileal-ureteral anastomotic stenosis in a 67-year-old patient. We aim to assess the feasibility of using Allium URS in such cases.
    METHODS: A 67-year-old Chinese woman was referred to our hospital for the treatment of left lumbago. Urography showed left ileal-ureteral anastomotic stenosis. Computed tomography (CT) revealed severe hydronephrosis in the left kidney. Subsequently, an Allium URS was implanted via ureteroscopy. We found no instances of haematuria, lumbago or urinary tract irritation during the follow-up period. After 8 months, the patient was readmitted because of left lumbago. CT re-examination revealed that the left hydronephrosis had modestly improved. The Allium URS had detached and showed stone formation on its surface. For further treatment, ureteroscopy was performed and a new Allium URS was implanted. At 3-month follow-up, CT re-examination demonstrated that the stent had dislodged again but that the hydronephrosis in the left kidney had remarkably improved. Cystoscopy revealed that the stent had completely detached and that wall stones had attached on this surface. The stent was removed via cystoscopy. After 1 month, CT scanning showed that the left hydronephrosis of the patient had almost disappeared.
    CONCLUSIONS: Allium URS is effective in the treatment of hydronephrosis caused by ileal-ureteral anastomotic stenosis. Although complications, such as haematuria, lumbago and urinary tract irritation, are rare, complications, such as stent displacement and stone formation, may occur. Hence, caution must be exercised when considering the use of Allium URSs in the treatment of patients with ileal-ureteral anastomotic stenosis.
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  • 文章类型: Journal Article
    目的:输尿管狭窄是一种慢性疾病,可导致受累肾单位的尿引流阻塞,导致肾功能丧失。治疗方法可以分为两个主要标题:内在和重建程序。我们旨在研究自膨式Allium®输尿管支架的疗效和安全性,近年来已应用于输尿管狭窄的微创治疗。
    方法:在2017-2021年间应用Allium®输尿管支架的20例患者纳入研究。患者的人口统计学和临床特征,应用于患者的治疗细节,围手术期和术后并发症,前瞻性地记录和评估了应用于并发症的治疗方法和随访中的发现.
    结果:病因包括16例患者(80%)的尿路结石,恶性肿瘤3例(15%),1例(5%)的妇科手术。发现支架阻塞是3例患者(15%)中最常见的并发症。支架移位是2例患者中第二常见的并发症(10%)。我们继续对15例没有支架相关并发症和支架阻塞的患者进行随访。平均随访时间为28±15.7个月。
    结论:葱输尿管支架是一种有效、可靠的微创治疗输尿管狭窄的方法,并发症发生率可接受,处理并发症容易。
    Ureteral stricture is a chronic condition that can result in the obstruction of urinary drainage from the affected renal unit, leading to loss of renal function. Treatment methods can be categorized into two main headings: endourological and reconstructive procedures. We aimed to investigate the efficacy and safety of the self-expandable Allium® ureteral stent, which has been used in the minimally invasive treatment of ureteral stenosis in recent years.
    Twenty patients who were applied Allium® ureteral stent between 2017 and 2021 included in the study. The demographic and clinical characteristics of the patients, the details of the treatments applied to the patients, the perioperative and postoperative complications, the treatments applied for the complications and the findings in the follow-up were recorded and evaluated prospectively.
    Etiology included urolithiasis in 16 patients (80%), malignancy in 3 patients (15%), and a previous gynecological operation in 1 patient (5%). Stent obstruction was found to be the most common complication in 3 patients (15%). Stent migration was the second most common complication in 2 patients (10%). Our follow-up continues with 15 patients without stent-related complications and stent obstruction. The mean follow-up period was 28 ± 15.7 months.
    Allium ureteral stent is an effective and reliable method in the minimally invasive treatment of ureteral stricture with complications seen at acceptable rates and ease of treatment in the management of complications.
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  • 文章类型: Multicenter Study
    目的:肾移植(KT)受者的输尿管狭窄(US)与移植物长期存活较差相关。手术修复是护理的标准,和内窥镜治疗代表狭窄<3cm的替代方案。我们旨在确定KT患者中US的腔内治疗的有效性和安全性以及失败的预测因素。
    方法:在四个欧洲转诊中心进行了一项回顾性多中心研究,包括2009年至2021年期间所有接受美国内镜治疗的KT患者。临床成功定义为没有上尿路导管插入,随访期间的手术修复或移植切除。
    结果:共纳入44例患者。美国发病的中位时间为3.5个月(IQR1.9-10.8),狭窄的中位长度为10mm(IQR7-20).US的治疗涉及球囊扩张和激光切开34例(79.1%)和6例(13.9%),分别,而2名(4.7%)同时收到。Clavien-Dindo并发症很少见(10%);仅报告了一种Clavien≥III并发症。在最后一次随访时,临床成功率为61%(中位数=44.6个月)。在双变量分析中,鸭嘴形狭窄(vs.平/凹)与治疗成功相关(RR=0.39,p=0.04,95%CI0.12-0.76),而迟发性狭窄(KT后>3个月)治疗失败(RR=2.00,p=0.02,95%CI1.01-3.95)。
    结论:考虑到可接受的长期结果和这些程序的安全性,我们认为,对于选定的US型KT患者,应将内镜治疗作为一线治疗.那些在KT的3个月内诊断为短而鸭嘴形狭窄的患者似乎是最佳候选人。
    OBJECTIVE: Ureteral stenosis (US) in kidney transplant (KT) recipients is associated with poorer long-term graft survival. Surgical repair is the standard of care, and endoscopic treatment represents an alternative for stenosis < 3 cm. We aimed to determine the effectiveness and safety of endourological management of US in KT patients and predictors of failure.
    METHODS: A retrospective multicenter study was conducted in four European referral centers, including all KT patients with US managed endoscopically between 2009 and 2021. Clinical success was defined as the absence of upper urinary tract catheterization, surgical repair or transplantectomy during follow-up.
    RESULTS: A total of 44 patients were included. The median time to US onset was 3.5 months (IQR 1.9-10.8), the median length of stricture was 10 mm (IQR 7-20). Management of US involved balloon dilation and laser incision in 34 (79.1%) and 6 (13.9%) cases, respectively, while 2 (4.7%) received both. Clavien-Dindo complications were infrequent (10%); only one Clavien ≥ III complication was reported. Clinical success was 61% at last follow-up visit (median = 44.6 months). In the bivariate analysis, duckbill-shaped stenosis (vs. flat/concave) was associated with treatment success (RR = 0.39, p = 0.04, 95% CI 0.12-0.76), while late-onset stenosis (> 3 months post KT) with treatment failure (RR = 2.00, p = 0.02, 95% CI 1.01-3.95).
    CONCLUSIONS: Considering the acceptable long-term results and the safety of these procedures, we believe that the endoscopic treatment should be offered as a first-line therapy for selected KT patients with US. Those with a short and duckbill-shaped stenosis diagnosed within 3 months of KT seem to be the best candidates.
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  • 文章类型: Case Reports
    子宫切除术后无症状肾积水通常是短暂的。这里,我们介绍了一例52岁的女性,她因良性适应症而接受了全腹子宫切除术和双侧附件卵巢切除术。术后第二天检查出血的计算机断层扫描(CT)偶然发现双侧II级肾积水。无症状肾积水没有重新评估,妇科门诊随访在术后第43天因肌酐水平正常而终止.在术后第107天,患者注意到体重增加了10公斤,尿量减少,和全身性水肿。血清肌酐水平升高至5.4mg/dL,CT显示双侧III级肾积水。进行了紧急的双侧输尿管支架置入术,以治疗引起肾衰竭后的输尿管远端狭窄。术后10个月对右输尿管严格狭窄行输尿管膀胱造口术。切除的远端输尿管的组织学检查显示炎症和纤维化。子宫切除术后无症状肾积水进展为延迟性肾衰竭。
    Asymptomatic hydronephrosis following hysterectomy is generally transient. Here, we present the case of a 52-year-old woman who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for benign indications. Computed tomography (CT) to examine bleeding on the second postoperative day incidentally revealed bilateral grade II hydronephrosis. Asymptomatic hydronephrosis was not reevaluated, and gynecological outpatient follow-up was terminated with a normal creatinine level on postoperative day 43. On postoperative day 107, the patient noticed weight gain of 10 kg, decreased urine output, and generalized edema. The serum creatinine level was elevated to 5.4 mg/dL, and CT revealed bilateral grade III hydronephrosis. Urgent bilateral ureteral stenting was performed to treat stenosis of the distal ureters that caused postrenal failure. Ureteroneocystostomy was performed for strict stenosis of the right ureter at 10 months postoperatively. Histological examination of the resected distal ureter showed inflammation and fibrosis. Asymptomatic hydronephrosis developing after hysterectomy progress to delayed postrenal failure.
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  • 文章类型: Case Reports
    UNASSIGNED:描述我们使用“切光”技术治疗医源性输尿管狭窄的新内镜方法。
    UNASSIGNED:一名54岁女性患者接受了右经皮肾镜取石术治疗鹿角状结石,随后进行了两次输尿管镜检查,并发严重的输尿管近端梗阻。使用顺行柔性输尿管镜和逆行刚性输尿管镜来定位狭窄。借助365µmHo:YAG激光光纤(设置为0.4J,12Hz),我们成功地在狭窄病变处制造了一个小切口,通过顺行输尿管软镜可以清楚地看到硬输尿管镜检查光,然后放置穿通导丝,保护输尿管。然后进行输尿管扩张,然后对输尿管狭窄进行全厚度切口。一个8Fr,碎石后最终放置28cm双J输尿管支架。
    未经评估:操作时间为200分钟。没有失血。手术后不久未出现发热或尿路感染症状。术后第一天成功移除Foley导管。住院时间只有2天。
    UNASSIGNED:“开光”技术是输尿管狭窄治疗的新应用,以前文献中很少描述过。这种方法的使用似乎提供了出色的结果,因此证明了这种微创技术作为常规侵入性方法的替代方法的重要性。我们认为,需要进行更大样本和更长时间随访的研究,以充分确定该方法的益处,并评估和揭示其合适的应用及其缺点。
    UNASSIGNED: To describe our new endoscopic approach in treating iatrogenic ureteral stenosis using the \"cut-to-The-light\" technique.
    UNASSIGNED: Case of a 54 year-old female patient who underwent a right percutaneous nephrolithotomy to treat a staghorn calculus with two subsequent complimentary ureteroscopies complicated by a severe proximal ureteral obstruction. An antegrade flexible uretereroscope and a retrograde rigid ureteroscope were used to locate the stenosis. With the aid of a 365-µm Ho: YAG laser fiber (settings 0.4 J, 12 Hz), we managed to successfully create a small incision in the stenotic lesion, the rigid ureterscopy light was clearly seen by the antegrade flexible ureteroscope and a through-and-through guidewire was then placed, securing the ureter. Ureteral dilatation was then performed followed by a full thickness incision of the ureteral stenosis. A single 8Fr, 28 cm double J ureteral stent was finally placed after stone fragmentation.
    UNASSIGNED: The operating time was 200 mins. No blood loss. No fever or signs of UTI were seen shortly after the operation. The Foley catheter was successfully removed at day one post-op. The hospital stay was short of only 2 days.
    UNASSIGNED: The \"cut-to-the-light\" technique is a new application in the arsenal of ureteral stricture treatment that has been scarcely described in the literature before. The use of this method seems to offer excellent outcomes thus demonstrating the importance of this minimally invasive technique as an alternative to conventional invasive methods used. We believe that studies with larger samples and longer follow up are needed in order to fully determine the benefits of this method and to assess and reveal its suitable application and its drawbacks.
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