背景:争议围绕持久性有机污染物(POPs)对胎儿发育的影响。这项研究旨在调查土耳其sanlüurfa母亲的脐带血中多氯联苯(PCBs)和有机氯农药(OCPs)的水平,探索与胎龄和出生体重的关系。
方法:参与者包括自愿怀孕的母亲,提供有关孕产妇因素的详细信息。分娩后立即收集脐带血样品。用改良的QuEChERS方法提取样品,和OCP(17种农药)和多氯联苯(11种同源物)化合物的水平用气相色谱/质谱分析。根据妊娠期和出生体重,计算并比较了单一污染物类型和污染物组的POPs检测频率和水平。我们使用偏最小二乘判别分析来识别关键化学品并区分它们各自的状态。
结果:在120名婴儿中,35岁是早产,但适合胎龄,35例足月但小于胎龄(SGA),50为足月和适合胎龄(AGA)。乙型六氯环己烷,Oxy-Chlordan,和PCB28,在脐带血样本中未检测到。一半的样品含有至少4种类型的OCP,OCP水平中位数为38.44ng/g。在DDT中,在脐带血浆样品中发现2,4'-DDE浓度最高。频率超过50%的PCB同源物按以下顺序排名:151、149、138、146。∑PCBs的中位数为5.93ng/g。足月出生的男性婴儿SGA状态表现出较低水平的∑DDTs,∑OCP与早产或足月出生的男性婴儿相比具有AGA状态。足月出生的SGA状态的男婴的二位取代多氯联苯和六氯化多氯联苯高于早产的AGA状态的男婴。
结论:总体而言,暴露于滴滴涕和多氯联苯显示出不同的影响,这取决于妊娠期和出生体重,暴露水平也因性别而异。这强调了跨不同人群进行研究的必要性,以调查多种污染物暴露对胎龄的综合影响。出生体重,性别同时
BACKGROUND: Controversy surrounds the impact of persistent organic pollutants (POPs) on fetal development. This study aimed to investigate levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in umbilical cord blood from Şanlıurfa mothers in Turkey, exploring associations with gestational age and birth weight.
METHODS: Participants included voluntary mothers pregnant with a single fetus, providing details on maternal factors. Cord blood samples were collected immediately after delivery. Samples were extracted with a modified QuEChERS method, and OCPs (17 pesticides) and PCBs (11 congeners) compound levels were analyzed with a gas chromatograph/mass spectrometry. Detection frequencies and levels of POPs by single pollutant type and pollutant groups were calculated and compared according to gestational duration and birth weight. We used partial least squares discriminant analysis to identify the key chemicals and distinguish their respective statuses.
RESULTS: Among 120 infants, 35 were preterm but appropriate for gestational age, 35 were term but small for gestational age (SGA), and 50 were term and appropriate for gestational age (AGA). Beta HCH, Oxy-Chlordan, and PCB 28, were not detected in cord blood samples. Half of the samples contained at least 4 types of OCPs, with a median OCP level of 38.44 ng/g. Among the DDT, 2,4\'-DDE was found at the highest concentration in cord plasma samples. The PCB congeners with a frequency exceeding 50% were ranked in the following order: 151, 149, 138, 146. The median level of ∑PCBs was 5.93 ng/g. Male infants born at term with SGA status exhibited lower levels of ∑DDTs, ∑OCPs compared to male infants born preterm or at term with AGA status. Di-ortho-substituted PCBs and hexachlorinated PCBs were higher in male infants born at term with SGA status than male infants born preterm with AGA status.
CONCLUSIONS: Overall, exposure to DDT and PCBs demonstrates varying effects depending on gestational duration and birth weight, with exposure levels also differing by gender. This underscores the necessity for studies across diverse populations that investigate the combined effects of multiple pollutant exposures on gestational age, birth weight, and gender simultaneously.