假单胞菌门是环境中最具代表性的门之一,在人类口腔中的患病率相对较低。Pseudomonadota的普遍存在以及口腔是来自外部来源的细菌最有可能进入的入口这一事实,因此需要更好地了解其在人类界面环境中的发生。然而,相关的口语Pseudomonadota在科学文献中被大量的研究,本次审查旨在通过以下方式解决的差距,第一次,概述了口腔中Pseudomonadota的多样性和生态学。科学文献和人类微生物组数据库的筛选揭示了1328例口腔中Pseudomonadota的报告。其中大多数属于β-和γ-变形杆菌,主要是奈瑟氏菌科,弯曲杆菌科,和巴氏杆菌科。其他定期报告的还包括肠杆菌属,克雷伯菌属,不动杆菌,埃希氏菌,伯克霍尔德利亚,或者柠檬酸杆菌,其成员具有获得毒力和抗生素抗性基因的高潜力。这篇综述提供了证据,表明临床相关的环境假单胞菌可能通过口腔定殖人类。证明了需要进一步研究环境-口腔界面上的假单胞菌及其作为可能参与毒力和抗生素抗性传播的载体的作用。关键点:•奈瑟氏菌科,弯曲杆菌科,和巴氏杆菌科是核心口腔微生物组的一部分•肠杆菌科,不动杆菌,或伯克霍尔德菌在口腔微生物组中常见•肠道菌群失调可能与普遍存在的口腔假单胞菌定植有关。
The phylum Pseudomonadota is amongst the most represented in the environment, with a comparatively lower prevalence in the human oral cavity. The
ubiquity of Pseudomonadota and the fact that the oral cavity is the most likely entry portal of bacteria from external sources underlie the need to better understand its occurrence in the interface environment-humans. Yet, the relevance oral Pseudomonadota is largely underexplored in the scientific literature, a gap that this review aims at addressing by making, for the first time, an overview of the diversity and ecology of Pseudomonadota in the oral cavity. The screening of scientific literature and human microbiome databases unveiled 1328 reports of Pseudomonadota in the oral cavity. Most of these belonged to the classes Beta- and Gammaproteobacteria, mainly to the families Neisseriaceae, Campylobacteriaceae, and Pasteurelaceae. Others also regularly reported include genera such as Enterobacter, Klebsiella, Acinetobacter, Escherichia, Burkholderia, or Citrobacter, whose members have high potential to acquire virulence and antibiotic resistance genes. This review provides evidence that clinically relevant environmental Pseudomonadota may colonize humans via oral cavity. The need for further investigation about Pseudomonadota at the environment-oral cavity interface and their role as vectors potentially involved in virulence and antibiotic resistance transmission is demonstrated. KEY POINTS: • Neisseriaceae, Campylobacteriaceae, and Pasteurelaceae are part of the core oral microbiome • Enterobacteriaceae, Acinetobacter, or Burkholderia are frequent in the oral microbiome • Gut dysbiosis may be associated with colonization by ubiquitous oral Pseudomonadota.