背景:1型胃神经内分泌肿瘤(NETs)相对罕见,以至于一些医生在诊断和治疗方面经验不足。这项研究的目的是通过分析和总结我们中心1型胃NETs患者的管理和预后来增加对该疾病的了解。
方法:回顾性分析2011-2022年在本中心接受治疗的229例1型胃NETs患者(59.4%为女性)的临床资料。
结果:患者平均年龄为50.5±10.8岁。多肿瘤累及72.5%的患者;66.4%的肿瘤<1cm,69.4%为NETG1,2.2%为III-IV期。共有76.9%的患者接受了内镜治疗,60.7%曾接受过中医治疗,10.5%接受生长抑素类似物治疗,6.6%接受了手术切除。70例患者(41.2%)在中位随访31个月后首次复发(范围:2-122个月),中位无复发时间为43个月.1-,2-,3年累计无复发生存率为71.8%,56.8%,50.3%,分别。在39个月的中位随访期间(范围:2-132个月),1例患者有双侧肺转移,未观察到与疾病相关的死亡。
结论:1型胃NETs复发率高,病程长,强调长期全面管理的重要性。
BACKGROUND: Type 1 gastric neuroendocrine tumors (NETs) are relatively rare to the extent that some physicians have little experience in diagnosing and treating them. The purpose of this study was to increase the understanding of the disease by analyzing and summarizing the management and prognoses of patients with type 1 gastric NETs at our center.
METHODS: The data of 229 patients (59.4% female) with type 1 gastric NETs who were treated at our center during 2011-2022 were retrospectively analyzed.
RESULTS: The average patient age was 50.5 ± 10.8 years. Multiple tumors affected 72.5% of the patients; 66.4% of the tumors were < 1 cm, 69.4% were NET G1, and 2.2% were stage III-IV. A total of 76.9% of the patients had received endoscopic management, 60.7% had received traditional Chinese medicine treatment, 10.5% received somatostatin analogues treatment, and 6.6% underwent surgical resection. Seventy patients (41.2%) experienced the first recurrence after a median follow-up of 31 months (range: 2-122 months), and the median recurrence-free time was 43 months. The 1-, 2-, and 3-year cumulative recurrence-free survival rates were 71.8%, 56.8%, and 50.3%, respectively. During a median follow-up of 39 months (range: 2-132 months), one patient had bilateral pulmonary metastasis, and no disease-related deaths were observed.
CONCLUSIONS: Type 1 gastric NETs have a high recurrence rate and a long disease course, underscoring the importance of long-term and comprehensive management.