目的:肿瘤手术治疗后脑室开放产生术后并发症的可能性往往限制了肿瘤的切除程度。这项研究旨在确定在小儿人群中切除幕上轴内脑肿瘤的手术中,心室开放是否与更多并发症相关。
方法:对2002年至2020年期间在IOP/GRAACC接受治疗的19岁以下患者进行了回顾性回顾分析,并接受了手术进行了幕上轴内原发性脑肿瘤切除术。收集了43例患者的数据。
结果:胶质肿瘤比非胶质肿瘤更常见(65%vs.35%,p=0.09)。心室开放与肿瘤向神经轴的扩散无关(6%与0,p>0.9)或软脑膜(3%vs.0,p>0.9)。在心室开放的患者中,10%出现脑积水需要治疗,而无心室开放组的患者均未发生脑积水(p=0.5)。关于脑室炎也没有统计学差异。术后硬膜下水瘤形成与心室开放相关(43%vs.0,p=0.003)。在1年、5年和10年的生存率与心室开放的病例为93.2%,89.7%,75.7%,分别,而在没有心室开放的情况下,是100%,83%,83%,分别,分别,死亡率曲线之间没有统计学差异。
结论:我们的研究表明,心室侵犯与显著并发症的发生无关。这与硬膜下水瘤的形成有关,这不需要额外的治疗。
The possibility that ventricular opening generates postoperative complications after surgical tumor treatment often restricts the degree of tumor resection. This study aims to determine whether the ventricular opening is associated with more complications in surgeries for resectioning supratentorial intra-axial brain tumors in the pediatric population.
A retrospective review analysis was performed of patients treated at IOP/GRAACC between 2002 and 2020 under 19 years of age and underwent surgery for supratentorial intra-axial primary brain tumor resection. Data were collected from 43 patients.
Glial tumor was more common than non-glial (65% vs. 35%, p = 0.09). The ventricular opening was not related to neoplastic spreads to the neuroaxis (6% vs. 0, p > 0.9) or leptomeningeal (3% vs. 0, p > 0.9). Of the patients whose ventricle was opened, 10% developed hydrocephalus requiring treatment, while none of the patients in the group without ventricular opening developed hydrocephalus (p = 0.5). There was also no statistical difference regarding ventriculitis. Postoperative subdural hygroma formation correlated with the ventricular opening (43% vs. 0, p = 0.003). The survival at 1, 5, and 10 years of cases with the ventricular opening was 93.2%, 89.7%, and 75.7%, respectively, while in cases without ventricular opening, it was 100%, 83%, and 83%, respectively, respectively, with no statistical difference between the mortality curves.
Our study demonstrated that ventricular violation was not associated with the occurrence of significant complications. It was related to the formation of subdural hygroma, which did not require additional treatment.