■评估使用心包组织标本进行结核性心包炎(TBP)诊断的结核分枝杆菌(MTB)-RNA测定的准确性。
■对疑似TBP患者进行MTB培养和MTB-RNA测定。敏感性,特异性,阳性预测值(PPV),负预测值(NPV),分析这两种测定的曲线下面积(AUC)。
■这项研究包括79名患者。敏感性,特异性,PPV,NPV,AUC为28.1%(18/64),100.0%(15/15),100.0%(18/18),24.6%(15/61),MTB培养为0.64,37.5%(24/64),100.0%(15/15),100.0%(24/24),27.3%(15/55),MTB-RNA分析为0.69,分别。心包组织培养阳性的患者被定义为有明确的TBP;换句话说,文化是这组患者的金标准,并且具有敏感性,特异性,PPV,净现值为100%,AUC为1.00。然而,这些值被发现为72.2%(13/18),100.0%(15/15),100.0%(13/13),75.0%(15/20),MTB-RNA分析为0.86,分别。在可能的TBP患者(培养阴性患者)中,灵敏度,特异性,NPV,MTB培养的AUC为0.0%(0/46),100.0%(15/15),24.6%(15/61),和0.50,分别但无法确定PPV。这些值被发现是23.9%(11/46),100.0%(15/15),100.0%(11/11),30.0%(15/50),MTB-RNA分析为0.62,分别。
■使用心包组织的MTB-RNA测定对TBP的诊断功效有限。在文化阳性TBP中,MTB-RNA的诊断准确性良好.相比之下,在文化阴性的TBP中,其诊断准确性不能令人满意.
UNASSIGNED: To assess the accuracy of the Mycobacterium tuberculosis (MTB)-RNA assay using pericardial tissue specimens for tuberculous pericarditis (TBP) diagnosis.
UNASSIGNED: MTB culture and MTB-RNA assay were performed for patients with suspected TBP. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of these two assays were analyzed.
UNASSIGNED: This study included 79 patients. The sensitivity, specificity, PPV, NPV, and AUC were 28.1% (18/64), 100.0% (15/15), 100.0% (18/18), 24.6% (15/61), and 0.64 for the MTB culture and 37.5% (24/64), 100.0% (15/15), 100.0% (24/24), 27.3% (15/55), and 0.69 for the MTB-RNA assay, respectively. Patients with positive pericardial tissue culture were defined as having definite TBP; in other words, culture was the gold standard for this group of patients and had a sensitivity, specificity, PPV, and NPV of 100% and an AUC of 1.00. However, these values were found to be 72.2% (13/18), 100.0% (15/15), 100.0% (13/13), 75.0% (15/20), and 0.86 for the MTB-RNA assay, respectively. Among patients with probable TBP (culture-negative patients), the sensitivity, specificity, NPV, and AUC of MTB culture were 0.0% (0/46), 100.0% (15/15), 24.6% (15/61), and 0.50, respectively, but the PPV could not be determined. These values were found to be 23.9% (11/46), 100.0% (15/15), 100.0% (11/11), 30.0% (15/50), and 0.62 for the MTB-RNA assay, respectively.
UNASSIGNED: MTB-RNA assay using pericardial tissues had limited diagnostic efficacy for TBP. In culture-positive TBP, the diagnostic accuracy of MTB-RNA was good. In contrast, in culture-negative TBP, its diagnostic accuracy was unsatisfactory.