研究人员总是得出结论,不支持该假设的结果不重要,不值得,或者根本不够好出版。然而,消极的发现对于科学的进步及其自我纠正性至关重要。我们也相信负面结果的重要性和不可或缺性。因此,在这次审查中,我们讨论了导致阴性结果发表偏倚的因素以及评估阴性结果的真实性和有效性的问题.此外,我们强调了在心血管研究中报告阴性结果的重要性,包括治疗,并表明负面结果可以澄清心血管疾病治疗中先前有争议的话题,并促进精准心血管疾病预防和治疗研究的翻译。
Researchers have always concluded that results that do not support the hypothesis as unimportant, unworthy, or simply not good enough for publication. However, negative findings are essential for the progress of science and its self-correcting nature. We also believe in the importance and indispensability of negative results. Therefore, in this review, we discussed the factors contributing to the publication bias of negative results and the problems to assess the factuality and validity of negative results. Moreover, we emphasized the importance of reporting negative results in cardiovascular research, including treatments, and suggest that the negative results could clarify previously controversial topics in the treatment of cardiovascular diseases and prompt the translation of research on precision cardiovascular disease prevention and treatment.