目的:本研究旨在调查短暂性全身健忘症(TGA)后癫痫的风险。
方法:研究人群在2002年至2020年间使用韩国国民健康保险服务数据库中的国际疾病分类代码进行招募。在TGA(n=12,390)和非TGA(n=33,868)组之间比较癫痫的发生率,使用1:3倾向评分匹配确定。使用Cox比例风险回归模型,与非TGA组相比,我们获得了TGA中发作性癫痫的校正风险比(aHRs)和95%置信区间(CIs).进行Logistic回归以检查TGA组中确定发作性癫痫的独立变量,并计算调整后比值比(aOR)和95%CI。
结果:TGA组癫痫的累积发病率明显高于对照组(p<0.001,对数秩检验)。在Cox模型中,TGA与癫痫发作显著相关(校正HR1.46,95%CI1.36-1.56)。调整后的逻辑回归显示,年龄(每1岁,OR1.02,95%CI1.01-1.02),女性(aOR0.68,95%CI0.60-0.77),高血压(aOR1.14,95%CI1.00-1.30),糖尿病(aOR1.26,95%CI1.10-1.44),中风(AOR1.22,95%CI1.06-1.40),抑郁症(aOR1.44,95%CI1.22-1.69),焦虑(aOR1.31,95%CI1.14-1.51),酒精相关疾病(aOR1.96,95%CI1.38-2.78),低收入(aOR1.18,95%CI1.02-1.36)和农村居民(aOR1.20,95%CI1.02-1.42)与癫痫发作相关.
结论:我们的研究结果表明TGA与癫痫发作有纵向关联。
OBJECTIVE: This study aimed to investigate the risk of epilepsy after transient global amnesia (TGA).
METHODS: Study population was recruited using the International Classification of Diseases codes from the Korean National Health Insurance Service database between 2002 and 2020. The incidence of epilepsy was compared between the TGA (n=12,390) and non-TGA (n=33,868) groups, determined using 1:3 propensity score matching. Using Cox proportional hazard regression model, we obtained adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident epilepsy in the TGA compared with non-TGA group. Logistic regression was performed to examine the independent variables determining incident epilepsy in the TGA group, and adjusted odds ratios (aORs) and 95% CIs were calculated.
RESULTS: The TGA group had a significantly higher cumulative incidence of epilepsy than controls (p <0.001, log-rank test). TGA was significantly associated with incident epilepsy in the Cox model (adjusted HR 1.46, 95% CI 1.36-1.56). The adjusted logistic regression showed that age (per 1 year, aOR 1.02, 95% CI 1.01-1.02), female sex (aOR 0.68, 95% CI 0.60-0.77), hypertension (aOR 1.14, 95% CI 1.00-1.30), diabetes (aOR 1.26, 95% CI 1.10-1.44), stroke (aOR 1.22, 95% CI 1.06-1.40), depression (aOR 1.44, 95% CI 1.22-1.69), anxiety (aOR 1.31, 95% CI 1.14-1.51), alcohol-related disease (aOR 1.96, 95% CI 1.38-2.78), low income (aOR 1.18, 95% CI 1.02-1.36) and rural residence (aOR 1.20, 95% CI 1.02-1.42) were associated with incident epilepsy.
CONCLUSIONS: Our results suggest a longitudinal association of TGA with incident epilepsy.