背景:卵巢癌在妇科肿瘤死亡率中排名第一。因为卵巢癌早期没有明显的症状,大多数患者在诊断时处于疾病的晚期。卵巢癌的发病率逐年上升,卵巢癌的发病率有年轻化的趋势。近年来。中医药对提高癌症患者的生活质量,减少药物毒性,预防转移和复发,提高放疗和化疗的疗效,延长生存时间,所以患者受益良多。
目的:综述中药有效成分在卵巢癌中的作用机制和分子途径。探讨中医药治疗卵巢癌的优势。本综述为中医药在卵巢癌治疗中的应用提供理论支持,为其临床预防和治疗提供新的视角。
方法:这篇综述对PubMed进行了文献检索,WebofScience,万方数据库,和中国知识基础设施(CNKI)关于中药活性成分预防卵巢癌的相关研究。搜索词包括“卵巢癌”和“中草药”,\"\"草药,\"\"中药,\"和\"中药有效成分\"。基于现有的实验和临床研究,本文对中医药治疗卵巢癌的作用机制进行了系统的总结和分析。
结果:中药有效成分通过诱导肿瘤细胞凋亡抑制卵巢癌的发生发展,抑制肿瘤细胞增殖,抑制肿瘤细胞迁移和侵袭,诱导肿瘤细胞自噬,促进上皮-间质转化,并提高放疗和化疗药物的疗效。中医药为卵巢癌患者提供了综合治疗选择,与放疗和化疗药物协同提高治疗效果,为临床治疗带来新的希望和可能性。
结论:中药有效成分可抑制卵巢癌的发生发展,但是需要进一步的临床研究来支持它们的应用。
BACKGROUND: Ovarian cancer ranks the first in the mortality of gynecological tumors. Because there are no obvious symptoms in the early stage of ovarian cancer, most patients are in the advanced stage of the disease at the time of diagnosis. The incidence of ovarian cancer is increasing year by year, and the incidence of ovarian cancer has a trend of younger age. In recent years. Traditional Chinese medicine (TCM) has a significant impact on improving the quality of life of cancer patients, reducing drug toxicity, preventing metastasis and recurrence, enhancing the efficacy of radiotherapy and chemotherapy, and prolonging survival time, so patients have benefited a lot.
OBJECTIVE: This review summarizes the mechanisms and molecular pathways through which active ingredients of TCM act in ovarian cancer. It explores the advantages of TCM in treating ovarian cancer. This review provides theoretical support for the use of TCM in the treatment of ovarian cancer, offering new perspectives for its clinical prevention and treatment.
METHODS: This review conducted a literature search on PubMed, Web of Science, Wanfang Database, and China National Knowledge Infrastructure (CNKI) for relevant studies on TCM active ingredients in preventing ovarian cancer. The search terms included \"ovarian cancer\" combined with \"Chinese herbal medicine,\" \"Herbal medicine,\" \"Traditional Chinese medicine,\" and \"Active ingredients of Chinese medicine\". Based on existing experimental and clinical research, the paper systematically summarized and analyzed the mechanisms of TCM in treating ovarian cancer.
RESULTS: Active ingredients of TCM inhibit the occurrence and development of ovarian cancer through inducing tumor cell apoptosis, inhibiting tumor cell proliferation, suppressing tumor cell migration and invasion, inducing tumor cell autophagy, promoting epithelial-mesenchymal transition, and enhancing the efficacy of radiotherapy and chemotherapy drugs. Chinese medicine provides a comprehensive treatment option for ovarian cancer patients, synergizing with radiotherapy and chemotherapy drugs to enhance treatment effectiveness and introduce new hope and possibilities in clinical therapy.
CONCLUSIONS: Active ingredients of TCM can inhibit the occurrence and development of ovarian cancer, but further clinical research is needed to support their application.