total hysterectomy

全子宫切除术
  • 文章类型: Case Reports
    孤立性纤维性肿瘤是罕见的间充质肿瘤,通常发生在胸膜。子宫颈孤立性纤维瘤并不常见。我们报告了第一例患者,该患者因阴道壁腺癌接受了全子宫切除术,并被发现在子宫颈旁子宫并发孤立性纤维瘤。
    一名51岁女性因接触性出血入院。妇科检查发现阴道壁上有3.0×1.0厘米的结节,阴道镜活检显示阴道壁腺癌。在推荐的分期检查之后,患者接受了全子宫切除术,双附件切除术,盆腔淋巴结清扫术,阴道壁切除术.手术期间,在左侧宫颈旁区的肿块中间发现约2×2cm的结节。随后的术后组织病理学检查证实宫颈孤立性纤维瘤伴阴道壁腺癌。患者住院后随访46个月,未观察到复发或远处转移。
    在极少数情况下,孤立性纤维瘤可在宫颈或阴道壁形成大肿块。在手术前和手术中,它们很容易被误诊为良性或恶性宫颈肿瘤。术后病理及免疫组化有助于诊断。大多数孤立性纤维性宫颈肿瘤是良性的,偶尔有低恶性潜能,手术治疗是可行和有效的。
    UNASSIGNED: Solitary fibrous tumors are rare mesenchymal tumors that typically occur in the pleura. Solitary fibrous tumors of the uterine cervix are uncommon. We report the first case of a patient who underwent total hysterectomy for vaginal wall adenocarcinoma and was found to have a concurrent solitary fibrous tumor in the paracervical-uterus.
    UNASSIGNED: A 51-year-old woman was admitted to our hospital due to contact bleeding. A gynecological examination revealed nodules of 3.0 × 1.0 cm on the vaginal wall, and a colposcopy with biopsy revealed adenocarcinoma of the vaginal wall. After the recommended staging examinations, the patient underwent total hysterectomy, double adnexectomy, pelvic lymph node dissection, and vaginal wall resection. During surgery, a nodule measuring approximately 2 × 2 cm was found in the middle of the mass in the left paracervical region. Subsequent postoperative histopathological examination confirmed an solitary fibrous tumor of the uterine cervix with adenocarcinoma of the vaginal wall. The patient was followed up for 46 months after hospitalization, and no recurrence or distant metastases were observed.
    UNASSIGNED: In rare cases, solitary fibrous tumors may form large masses in the cervical or vaginal wall. They can easily be misdiagnosed as benign or malignant cervical tumors before and during surgery. Postoperative pathology and immunohistochemistry are helpful for diagnosis. Most solitary fibrous cervical tumors are benign, occasionally with low malignant potential, and surgical treatment is feasible and effective.
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  • 文章类型: Clinical Trial
    背景:子宫肌瘤是常见的良性妇科疾病。经历月经过多的患者,贫血,压力症状应该给药,严重的病例需要全子宫切除术。这种手术是侵入性的,会导致严重的术后疼痛,这会影响患者的术后睡眠质量,因此,恢复过程。
    目的:评价地佐辛在患者自控硬膜外镇痛(PCEA)中的应用,用于行子宫肌瘤切除术的患者术后疼痛管理。
    方法:我们选择了100例接受子宫肌瘤全腹全子宫切除术的患者,并随机分为两组:对照组接受0.2%罗哌卡因加0.06mg/mL吗啡,观察组接受0.2%罗哌卡因加0.3mg/mL二氮嗪的PCEA。评估的结果包括疼痛水平,镇静,恢复指数,PCEA使用情况,压力因素,和睡眠质量。
    结果:观察组视觉模拟量表评分较低,术后恢复指数较短,较少平均PCEA按压,降低皮质醇和血糖水平,多导睡眠图参数优于对照组(P<0.05)。观察组不良反应累积发生率低于对照组(P<0.05)。
    结论:地佐辛PCEA能有效控制子宫肌瘤全切术的疼痛,减少压力因素的负面影响,对患者睡眠的影响较小,从而导致更少的不利影响。
    BACKGROUND: Uterine fibroids are common benign gynecological conditions. Patients who experience excessive menstruation, anemia, and pressure symptoms should be administered medication, and severe cases require a total hysterectomy. This procedure is invasive and causes severe postoperative pain, which can affect the patient\'s postoperative sleep quality and, thus, the recovery process.
    OBJECTIVE: To evaluate use of dezocine in patient-controlled epidural analgesia (PCEA) for postoperative pain management in patients undergoing total myomectomy.
    METHODS: We selected 100 patients undergoing total abdominal hysterectomy for uterine fibroids and randomized them into two groups: A control group receiving 0.2% ropivacaine plus 0.06 mg/mL of morphine and an observation group receiving 0.2% ropivacaine plus 0.3 mg/mL of diazoxide in their PCEA. Outcomes assessed included pain levels, sedation, recovery indices, PCEA usage, stress factors, and sleep quality.
    RESULTS: The observation group showed lower visual analog scale scores, shorter postoperative recovery indices, fewer mean PCEA compressions, lower cortisol and blood glucose levels, and better polysomnographic parameters compared to the control group (P < 0.05). The cumulative incidence of adverse reactions was lower in the observation group than in the control group (P < 0.05).
    CONCLUSIONS: Dezocine PCEA can effectively control the pain associated with total myomectomy, reduce the negative impact of stress factors, and have less impact on patients\' sleep, consequently resulting in fewer adverse effects.
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  • 文章类型: Journal Article
    目的:比较接受全子宫切除术和节段性切除术(TH-SR)治疗有或没有保护性功能缺损造口(PDS)的肠道子宫内膜异位症的妇女的术后并发症。
    方法:2008年1月至2022年1月在里尔大学医院妇科(法国)进行的回顾性队列研究,对象是接受TH-SR治疗的肠型子宫内膜异位症患者。
    结果:100名女性被考虑进行分析。在56名女性中进行了PDS。PDS组直肠切除率明显较高(p=0.03)。平均手术时间,PDS组的AAGL评分和住院时间明显较高(p=0.002)。根据Clavien-Dindo分类,PDS组的III级并发症发生率更高(p=0.03)。在消化系统并发症中,非PDS组有1例吻合口漏(1.8%)和1例直肠阴道瘘(2.3%),PDS组出现吻合口狭窄4例(7.1%)。持续的膀胱收缩需要自我导管插入超过一个月是最常见的干扰(在非PDS组4.6%和PDS组7.1%,p=0.58)。消化道病变距肛门边缘的距离是消化道并发症的唯一危险因素。持续性膀胱收缩,多变量分析中的Clavien-DindoIIIA和IIIB并发症(分别为p=0.04和p=0.06)。
    结论:在实施或不预防造口的情况下,全子宫切除术和伴随节段切除术的消化道并发症发生率无统计学差异。
    OBJECTIVE: To compare postoperative complications in women undergoing total hysterectomy with segmental resection (TH-SR) for intestinal endometriosis with or without protective defunctioning stoma (PDS) confection.
    METHODS: Retrospective cohort study conducted at the Gynecologic department of University Hospital of Lille (France) from January 2008 to January 2022 in patients undergone TH-SR for bowel endometriosis.
    RESULTS: 100 women were considered for the analysis. PDS were performed in 56 women. The rate of rectal resections was significantly higher in the PDS group (p = 0.03). The mean operative time, AAGL scores and length of hospital stay were significantly higher in the PDS group (p = 0.002). The rate of grade III complication according to Clavien-Dindo classification was higher in the PDS group (p = 0.03). Among digestive complications, one case of anastomosis leakage (1.8%) and one case of recto-vaginal fistula (2.3%) was recorded in the non-PDS group, 4 cases of anastomosis stenosis were recorded in the PDS group (7.1%). Persisting bladder atony requiring self-catheterization over one month was the most common disturb (4.6% in the non-PDS group and 7.1% in the PDS group, p = 0.58). The distance of digestive lesion from anal margin was the only risk factor for digestive complications, persistent bladder atony, Clavien-Dindo IIIA and IIIB complications at the multivariate analysis (p = 0.04 and p = 0.06 respectively).
    CONCLUSIONS: No statistically significant differences were found in the rate of digestive complications in case of total hysterectomy and concomitant segmental resection when performing or not preventing stoma.
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  • 文章类型: Journal Article
    机器人辅助手术是二十世纪的一项技术进步,妇科是这种方法的主要采用者。增强手术系统从单部位经验中获得了全子宫切除术的突出地位,但目前文献中仍缺乏多站点报告。这项多站点研究,在克莱佩达大学医院和学术教学医院费尔德基奇进行,目的探讨增强手术系统全子宫切除术的安全性和可行性。该研究涉及295例,展示了一个完善的程序与最少的程序时间。患者平均年龄为53.5岁(SD:10.3岁),从18到80岁不等。患者的BMI平均为25.6kg/m2(SD:6.2kg/m2),范围从最小17.7kg/m2到最大69.5kg/m2。手术时间在30到215分钟之间变化,中位数为95分钟(IQR:81-116)。对接时间中位数为3(IQR:2-5)分钟,在1.0至30.0分钟之间变化,最小到最大范围为1.0到122分钟。转换(3例,1%)和不良事件(6例,2%)不常见。此外,在4,1%(12例)的手术中,机器人故障记录最少,0-10视觉疼痛量表的疼痛从术后一天的轻度[2.7(±1.2)]降低到出院时的轻度[0.9(±0.5)]。总的来说,一个伟大的例行程序与增强手术系统证明了良好的控制和,因此,可行性和安全性。因此,增强手术系统是全子宫切除术的可行选择。
    Robotic-assisted surgery emerged as a technological advancement in the twentieth century, with gynaecology being a key adopter of this approach. The Senhance Surgical System has gained prominence for total hysterectomies from single-site experiences, but multi-site reporting are still lacking in present literature. This multi-site study, conducted at Klaipeda University Hospital and Academic Teaching Hospital Feldkirch, aimed to explore the safety and feasibility of total hysterectomies with the Senhance Surgical System. The study involved 295 cases, showcasing a well-established routine with minimal procedure times. The average age of the patients was 53.5 years (SD: 10.3 years), ranging from 18 to 80 years. The patients\' BMI averaged 25.6 kg/m2 (SD: 6.2 kg/m2), ranging from a minimum of 17.7 kg/m2 to a maximum of 69.5 kg/m2. The duration of surgery varied between 30 and 215 min, with a median of 95 min (IQR: 81-116). The docking time was a median of 3 (IQR: 2-5) min and varied between 1.0 and 30.0 min, with a minimum to a maximum range of 1.0 to 122 min. Conversion (3 cases, 1%) and adverse events (6 cases, 2%) were infrequent. Additionally, robotic malfunctions were recorded minimally in 4,1% (12 cases) of the procedures, and pain on a 0-10 visual pain scale was reduced from mild [2.7 (± 1.2)] one day postoperative to minimal [0.9 (± 0.5)] at discharge. Overall, a great routine with the Senhance Surgical System proves good control and, thus, feasibility and safety. Therefore, the Senhance Surgical System is a viable option for total hysterectomy.
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  • 文章类型: Journal Article
    盆底肌肉训练(PFMT)已成为改善全子宫切除术(TH)后性功能的潜在干预措施。肌电图(EMG)生物反馈是一种可以改善预后的辅助手段。
    在这项研究中,我们旨在比较EMG生物反馈辅助PFMT和单独PFMT改善TH后女性性功能的作用。
    在这项前瞻性研究中,我们招募了2022年1月至2023年4月在我们医院接受TH治疗的妇女。参与者根据他们选择的治疗方法进行划分:EMG生物反馈辅助PFMT或单独PFMT。
    主要研究结果是使用女性性功能指数评估患者性功能的变化。次要结果是用医院焦虑和抑郁量表评分评估焦虑和抑郁的变化,用Glazer评估从治疗前后评估盆底肌力。
    共包括73名患者,38例患者接受肌电生物反馈辅助盆底肌肉训练。治疗后,与基线相比,所有患者的性功能均显著改善(均P<.001).与盆底肌训练患者相比,肌电生物反馈辅助盆底肌训练患者治疗前后女性性功能指数总分的变化明显高于对照组(均P<0.05)。两组患者治疗前后Glazer评分和医院焦虑抑郁量表评分的变化差异均无统计学意义(均P>0.05)。
    结果表明,肌电生物反馈辅助盆底肌肉训练可用于改善TH后患者的性功能。
    这项研究受到其单中心设计的限制,小样本量,缺乏随机化,和缺乏雌激素监测的参与者。
    肌电生物反馈辅助盆底肌肉训练在改善全子宫切除术后患者性功能方面似乎比单纯盆底肌肉训练更有效。
    UNASSIGNED: Pelvic floor muscle training (PFMT) has emerged as a potential intervention to improve post-total hysterectomy (TH) sexual function. Electromyographic (EMG) biofeedback is an adjunct that may improve outcomes.
    UNASSIGNED: In this study we aimed to compare the EMG biofeedback-assisted PFMT and PFMT alone for improving sexual function in women after TH.
    UNASSIGNED: For this prospective study we enrolled women undergoing TH in our hospital between January 2022 and April 2023. Participants were divided according to the treatment they selected: EMG biofeedback-assisted PFMT or PFMT alone.
    UNASSIGNED: The primary study outcome was change in patient sexual function evaluated by use of the Female Sexual Function Index. Secondary outcomes were changes in anxiety and depression evaluated with the Hospital Anxiety and Depression Scale score and pelvic floor muscle strength was evaluated with the Glazer assessment performed from before to after treatment.
    UNASSIGNED: A total of 73 patients were included, with 38 patients treated with Electromyographic biofeedback-assisted pelvic floor muscle training. After treatment, sexual function was significantly improved compared to baseline in all patients (all P < .001). Compared to patients with pelvic floor muscle training, the changes in total Female Sexual Function Index scores from before to after treatment in patients with Electromyographic biofeedback-assisted pelvic floor muscle training were significantly higher (all P < .05). There were no significant differences between the 2 groups in the changes in the Glazer score and Hospital Anxiety and Depression Scale scores from before to after treatment (both P > .05).
    UNASSIGNED: The results demonstrate that Electromyographic biofeedback-assisted pelvic floor muscle training may be used to improve the sexual function of patients following TH.
    UNASSIGNED: This study is limited by its single-center design, small sample size, lack of randomization, and absence of estrogen monitoring in enrolled participants.
    UNASSIGNED: Electromyographic biofeedback-assisted pelvic floor muscle training appears to be more effective than pelvic floor muscle training alone in improving sexual function among patients after total hysterectomy.
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  • 文章类型: Journal Article
    背景:围手术期尿路感染(PUTI)在美国很常见,并且是高医疗保健成本的重要原因。缺乏关于全子宫切除术(TH)后PUTI危险因素的大量研究。
    方法:我们使用2010年至2019年的全国住院患者样本(NIS)进行了一项回顾性研究,以分析与TH围手术期相关的PUTI的危险因素和年发生率。
    结果:在9087名患者中发现了PUTIs,显示2.0%的发病率。不同年龄段的PUTI发生率存在显著差异(P<0.001)。在两组之间,保险类型一直存在显着差异,医院位置,病床尺寸,医院类型(P<0.001)。患有PUTIs的患者表现出明显更多的合并症(P<0.001)。毫不奇怪,PUTIs患者的中位住院时间更长(5天vs.2天;P<0.001)和更高的院内死亡率(从0.1到1.1%;P<0.001)。因此,总住院费用中位数增加了27,500美元(60,426美元与$32,926,P<0.001),因为PUTIs增加了医疗费用。PUTIs患者的择期住院较少见(66.8%与87.6%;P<0.001)。根据多变量逻辑回归研究,以下是TH后PUTIs的风险变量:45岁以上;合并症数量(≥1);医院床位大小(中等,大型);教学医院;医院区域(南部,西部);术前合并症(酗酒,缺乏性贫血,慢性失血性贫血,充血性心力衰竭,糖尿病,药物滥用,高血压,甲状腺功能减退,淋巴瘤液体和电解质紊乱,转移性癌症,其他神经系统疾病,瘫痪外周血管疾病,精神病患者,肺循环障碍,肾功能衰竭,实体瘤无转移,瓣膜疾病,体重减轻);和并发症(脓毒症,急性心肌梗死,深静脉血栓形成,消化道出血,肺炎,中风,伤口感染,伤口破裂,出血,肺栓塞,输血,术后谵妄)。
    结论:研究结果表明,识别这些危险因素可以改善TH患者的PUTIs的预防策略和管理。应在手术前进行咨询,以减少PUTI的发生率。
    在医疗实践中,风险因素的识别可以改善患者的预防和治疗策略.我们使用2010年至2019年的全国住院患者样本(NIS)进行了一项回顾性研究,以分析与TH围手术期相关的PUTI的危险因素和年发生率。在9087名患者中发现了PUTI,显示2.0%的发病率。我们发现住院时间增加,医疗费用,先前存在的合并症的数量,医院的大小,教学医院,和地区也在UTI的风险中发挥作用。
    泌尿外科。
    BACKGROUND: Perioperative urinary tract infections (PUTIs) are common in the United States and are a significant contributor to high healthcare costs. There is a lack of large studies on the risk factors for PUTIs after total hysterectomy (TH).
    METHODS: We conducted a retrospective study using a national inpatient sample (NIS) of 445,380 patients from 2010 to 2019 to analyze the risk factors and annual incidence of PUTIs associated with TH perioperatively.
    RESULTS: PUTIs were found in 9087 patients overall, showing a 2.0% incidence. There were substantial differences in the incidence of PUTIs based on age group (P < 0.001). Between the two groups, there was consistently a significant difference in the type of insurance, hospital location, hospital bed size, and hospital type (P < 0.001). Patients with PUTIs exhibited a significantly higher number of comorbidities (P < 0.001). Unsurprisingly, patients with PUTIs had a longer median length of stay (5 days vs. 2 days; P < 0.001) and a higher in-hospital death rate (from 0.1 to 1.1%; P < 0.001). Thus, the overall hospitalization expenditures increased by $27,500 in the median ($60,426 vs. $32,926, P < 0.001) as PUTIs increased medical costs. Elective hospitalizations are less common in patients with PUTIs (66.8% vs. 87.6%; P < 0.001). According to multivariate logistic regression study, the following were risk variables for PUTIs following TH: over 45 years old; number of comorbidities (≥ 1); bed size of hospital (medium, large); teaching hospital; region of hospital(south, west); preoperative comorbidities (alcohol abuse, deficiency anemia, chronic blood loss anemia, congestive heart failure, diabetes, drug abuse, hypertension, hypothyroidism, lymphoma, fluid and electrolyte disorders, metastatic cancer, other neurological disorders, paralysis, peripheral vascular disorders, psychoses, pulmonary circulation disorders, renal failure, solid tumor without metastasis, valvular disease, weight loss); and complications (sepsis, acute myocardial infarction, deep vein thrombosis, gastrointestinal hemorrhage, pneumonia, stroke, wound infection, wound rupture, hemorrhage, pulmonary embolism, blood transfusion, postoperative delirium).
    CONCLUSIONS: The findings suggest that identifying these risk factors can lead to improved preventive strategies and management of PUTIs in TH patients. Counseling should be done prior to surgery to reduce the incidence of PUTIs.
    UNASSIGNED: In medical practice, the identification of risk factors can lead to improved patient prevention and treatment strategies. We conducted a retrospective study using a national inpatient sample (NIS) of 445,380 patients from 2010 to 2019 to analyze the risk factors and annual incidence of PUTIs associated with TH perioperatively. PUTIs were found in 9087 patients overall, showing a 2.0% incidence. We found that noted increased length of hospital stay, medical cost, number of pre-existing comorbidities, size of the hospital, teaching hospitals, and region to also a play a role in the risk of UTI\'s.
    UNASSIGNED: Urogynecology.
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  • 文章类型: Case Reports
    胎盘早剥是一种严重的医疗状况,可能在怀孕期间发生,涉及分娩前胎盘与子宫内壁的过早分离。这种分离通常会导致严重的出血,如果常规方法在控制出血方面无效,子宫切除术可能被认为是必要的,以确保母亲的安全。这份病例报告详述了一名22岁女性的治疗情况,GravidaIV,第三段,她在第四次怀孕期间经历了胎盘早剥。紧急剖宫产导致严重的产后出血和弥散性血管内凝血(DIC)。可卡因和甲基苯丙胺的阳性药物测试进一步增加了复杂性,导致计划外子宫切除术以挽救生命。这个案例强调了早期识别的关键重要性,多学科合作,以及在药物滥用背景下及时干预管理产科紧急情况。
    Placental abruption is a serious medical condition that can occur during pregnancy, involving the premature separation of the placenta from the inner uterine wall before childbirth. This detachment often leads to severe bleeding, and if conventional methods prove ineffective in managing the bleeding, a hysterectomy may be deemed necessary to ensure the mother\'s safety. This case report details the management of a 22-year-old female, gravida IV, para III, who experienced placental abruption during her fourth pregnancy. An emergent cesarean section resulted in severe postpartum hemorrhage and disseminated intravascular coagulation (DIC). Positive drug tests for cocaine and methamphetamines added further complexity, leading to an unplanned hysterectomy for life-saving measures. This case underscores the critical importance of early recognition, multidisciplinary collaboration, and timely intervention in managing obstetric emergencies within the context of substance abuse.
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  • 文章类型: Journal Article
    目的:探讨宫颈高级别鳞状上皮内病变(HSIL)合并隐匿性宫颈癌的危险因素,规范HSIL初治管理。
    方法:收集2018-2023年2家三级医院和3家二级医院妇产科因HSIL直接行子宫全切除术患者的临床资料。它们的一般特征,分析病理参数和生存状态。采用Logistic回归模型分析临床参数与术后病理升级的相关性。
    结果:1.在314例直接行子宫全切除术的HSIL患者中,73.2%来自基层医院。2.25例患者(7.9%)病理升级为宫颈癌,所有这些都是早期浸润性癌症。3.到目前为止,25例早期浸润性癌患者没有复发或死亡,中位随访期为21个月(2-59个月)。4.腺体受累(OR3.968;95CI1.244-12.662)和病变范围≥3个象限(OR6.527;95%CI1.78-23.931),HPV16/18感染(OR5.382;95CI1.947-14.872),TCT≥ASC-H(OR4.719;95CI1.892-11.766)是影响术后病理升级的独立危险因素。5.Logistic回归模型计算的曲线下面积(AUC)为0.840,说明预测值较好。
    结论:HSIL患者存在隐匿性宫颈癌的风险。腺体参与,病变范围≥3个象限,HPV16/18感染和TCT≥ASC-H是HSIL合并隐匿性宫颈癌的独立危险因素。活检证实的HSIL患者接受筋膜外子宫切除术和意外的早期浸润性癌的预后可能很好。
    OBJECTIVE: To identify the risk factors of cervical high-grade squamous intraepithelial lesion(HSIL) complicated with occult cervical cancer and standardize the management of initial treatment for HSIL.
    METHODS: The clinical data of patients who underwent total hysterectomy directly due to HSIL in the obstetrics and gynecology department of two tertiary hospitals and three secondary hospitals from 2018 to 2023 were collected. Their general characteristics, pathological parameters and survival status were analyzed. Logistic regression model was used to analyze the correlation between clinical parameters and postoperative pathological upgrading.
    RESULTS: 1. Among the 314 patients with HSIL who underwent total hysterectomy directly, 73.2% were from primary hospitals. 2. 25 patients (7.9%) were pathologically upgraded to cervical cancer, all of which were early invasive cancer. 3. Up to now, there was no recurrence or death in the 25 patients with early-stage invasive cancer, and the median follow-up period was 21 months(range 2-59 months). 4. Glandular involvement(OR 3.968; 95%CI 1.244-12.662) and lesion range ≥ 3 quadrants (OR 6.527; 95% CI 1.78-23.931), HPV 16/18 infection (OR 5.382; 95%CI 1.947-14.872), TCT ≥ ASC-H (OR 4.719; 95%CI 1.892-11.766) were independent risk factors that affected the upgrading of postoperative pathology. 5. The area under the curve (AUC) calculated by the Logistic regression model was 0.840, indicating that the predictive value was good.
    CONCLUSIONS: There is a risk of occult cervical cancer in patients with HSIL. Glandular involvement, Lesion range ≥ 3 quadrants, HPV 16/18 infection and TCT ≥ ASC-H are independent risk factors for HSIL combined with occult cervical cancer. The prognosis of biopsy-proved HSIL patients who underwent extrafascial hysterectomy and unexpected early invasive cancer was later identified on specimen may be good.
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  • 文章类型: Journal Article
    目的:我们进行了这项研究,以评估全子宫切除术与根治性子宫切除术治疗神经内分泌宫颈癌(NECC)的疗效。
    方法:从监测中确定合格的NECC患者,流行病学和最终结果(SEER)数据库。人口特征,收集患者的临床治疗和生存情况。通过具有对数秩检验的Kaplan-Meier分析估计总生存期(OS)和癌症特异性生存期(CSS)。
    结果:共纳入286例患者,104例接受全子宫切除术的患者和182例接受根治性子宫切除术的患者。全子宫切除术组5年OS为50.8%,根治性子宫切除术组为47.5%(p=0.450);相应的5年CSS分别为51.6%和49.1%(p=0.494),分别。除了手术,全子宫切除术组49.0%,根治性子宫切除术组50.5%;全子宫切除术组77.9%,根治性子宫切除术组85.7%.出乎意料的是,在接受有或没有化疗的辅助放疗的患者中,全子宫切除术组的OS优于根治性子宫切除术组(p=0.034).而在单独接受化疗和既不接受放疗也不接受化疗的患者中,全子宫切除术组和根治性子宫切除术组的OS仍相当.
    结论:与根治性子宫切除术相比,在NECC患者中,全子宫切除术与生存预后受损无关.全子宫切除术有可能成为NECC多模式治疗的替代手术。
    OBJECTIVE: We conducted this study to evaluate the efficacy of total hysterectomy versus radical hysterectomy in the treatment of neuroendocrine cervical cancer (NECC).
    METHODS: Eligible NECC patients were identified from the Surveillance, Epidemiology and End Results (SEER) database. Demographic characteristics, clinical treatment and survival of the patients were collected. The overall survival (OS) and cancer-specific survival (CSS) were estimated by Kaplan-Meier analysis with log-rank test.
    RESULTS: A total of 286 patients were included, with 104 patients undergoing total hysterectomy and 182 patients undergoing radical hysterectomy. The 5-year OS were 50.8% in the total hysterectomy group and 47.5% in the radical hysterectomy group (p = 0.450); and the corresponding 5-year CSS were 51.6% and 49.1% (p = 0.494), respectively. Along with surgery, radiotherapy was given to 49.0% of patients in the total hysterectomy group and 50.5% in the radical hysterectomy group; and chemotherapy was administered to 77.9% of patients in the total hysterectomy group and 85.7% in the radical hysterectomy group. Unexpectedly, in patients who received adjuvant radiotherapy with or without chemotherapy, the OS was superior in the total hysterectomy group compared with the radical hysterectomy group (p = 0.034). While in patients who received chemotherapy alone and those who received neither radiotherapy nor chemotherapy, the OS still remained comparable between the total hysterectomy and radical hysterectomy group.
    CONCLUSIONS: Compared with radical hysterectomy, total hysterectomy was not associated with compromised survival prognosis in patients with NECC. Total hysterectomy has the potential to be a surgical alternative in the multimodal management of NECC.
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  • 文章类型: Case Reports
    背景:我们报告了一例患者,尽管按照规定预防围手术期静脉血栓栓塞(VTE),但术后出现严重肺栓塞。
    方法:一名50岁女性患者接受机器人子宫肌瘤全子宫切除术。她的围手术期VTE风险评估为中度,术后使用压缩和间歇空气压缩长袜,直到手术后的早晨。手术很顺利,患者在术后第4天出院。术后第19天,患者出现快速呼吸困难,并被诊断为严重的肺栓塞。
    结论:肝素,组织型纤溶酶原激活剂,服用了儿茶酚胺,病人恢复得很好。
    结论:微创妇科手术中的VTE措施尚不明确,未来可能有必要对妇科微创手术进行血栓风险评估.
    BACKGROUND: We report the case of a patient who developed a severe pulmonary embolus postoperatively despite perioperative venous thromboembolism (VTE) prophylaxis as prescribed.
    METHODS: A 50-year-old female patient underwent a robotic total hysterectomy for uterine fibroids. Her perioperative VTE risk was assessed as moderate, and compression and intermittent air compression stockings were used postoperatively until the morning following the surgery. The surgery was uneventful, and the patient was discharged on postoperative day 4. On postoperative day 19, the patient experienced rapid dyspnea and was diagnosed with a severe pulmonary embolus.
    CONCLUSIONS: Heparin, a tissue-type plasminogen activator, and a catecholamine were administered, and the patient recovered well.
    CONCLUSIONS: VTE measures in minimally invasive gynecologic surgery are not well defined, and future thrombotic risk assessments specific to minimally invasive gynecologic surgery may be necessary.
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