UNASSIGNED:可以使用双心室辅助装置(BVAD)治疗严重的双心室心力衰竭(BHF)。目前正在开发两种设备:通用心室辅助设备(UVAD),这将能够帮助左派,对,或者两个心室,和连续流全人工心脏(CFTAH),它取代了整个心脏。在这项研究中,将两种UVAD的体外血液动力学性能与充当BVAD的CFTAH进行比较。
未经评估:对于此实验,双心室模拟循环回路利用两个气动泵(AbiomedAB5000™,丹弗斯,MA,美国),结合双输出驱动器,造成心力衰竭(HF)状况(左,LHF;对,RHF;双心室,BHF)。重复了四种不同情况的收缩期BHF。在每种情况下,CFTAH和UVAD设备以两种不同的速度安装和运行,并评估了心室和心房连接的插管。
未经评估:CFTAH和UVAD设置均达到我们推荐的血流动力学标准。双UVAD布置产生更好的心房平衡以减轻LHF和RHF。对于中度和重度BHF情况,CFTAH和双UVAD都创造了优异的心房压力平衡。相反,当CFTAH为LHF和RHF进行心房插管时,未达到所需的心房压力平衡.
UNASSIGNED:对两种不同的BVAD设置进行的全面体外测试在(单设备和双设备)BHF支持方案中均表现出自我调节和出色的泵性能。用于治疗中度和重度BHF,UVAD和CFTAH在心房压力调节和心输出量方面均表现良好。不过,在所有BHF测试方案中,双UVAD设置均产生了更好的心房压力平衡.
UNASSIGNED: Severe biventricular heart failure (BHF) can be remedied using a biventricular assist device (BVAD). Two devices are currently in development: a universal ventricular assist device (UVAD), which will be able to assist either the left, right, or both ventricles, and a continuous-flow total artificial heart (CFTAH), which replaces the entire heart. In this study, the in vitro hemodynamic performances of two UVADs are compared to a CFTAH acting as a BVAD.
UNASSIGNED: For this experiment, a biventricular mock circulatory loop utilizes two pneumatic pumps (Abiomed AB5000™, Danvers, MA, USA), in conjunction with a dual-output driver, to create heart failure (HF) conditions (left, LHF; right, RHF; biventricular, BHF). Systolic BHF for four different situations were replicated. In each situation, CFTAH and UVAD devices were installed and operated at two distinct speeds, and cannulations for ventricular and atrial connections were evaluated.
UNASSIGNED: Both CFTAH and UVAD setups achieved our recommended hemodynamic criteria. The dual-UVAD arrangement yielded a better atrial balance to alleviate LHF and RHF. For moderate and severe BHF scenarios, CFTAH and dual UVADs both created excellent atrial pressure balance. Conversely, when CFTAH was atrial cannulated for LHF and RHF, the needed atrial pressure balance was not met.
UNASSIGNED: Comprehensive in vitro testing of two different BVAD setups exhibited self-regulation and exceptional pump performance for both (single- and dual-device) BHF support scenarios. For treating moderate and severe BHF, UVAD and CFTAH both functioned well with respect to atrial pressure regulation and cardiac output. Though, the dual-UVAD setup yielded a better atrial pressure balance in all BHF testing scenarios.