背景:Behcet病通常在怀孕期间随着缓解而进展,但是由于炎症,这些胎儿的心脏可能会出现早期的细微变化。
目的:我们的目的是评估患有Behcet病(BD)的孕妇胎儿的心功能。
方法:前瞻性病例对照研究。
方法:这项前瞻性研究纳入了妊娠前诊断患有Behcet病的孕妇。在32-34孕周,包括24例患有Behcet病的妊娠和48例健康妊娠。
方法:使用脉冲多普勒和组织多普勒成像(TDI)评估心功能。
结果:妊娠合并BD的患者右心室(RV)E(早期)波和左心室(LV)E明显增加(分别为p=.008,p=.041)。病例组用TDI检测到右心室E'(收缩期峰值速度)降低(6.2±0.5,p<.001)。病例组中RV和LV的E/E比值显著增加(分别为p<.001,p=.001)。还评估了疾病持续时间与胎儿心脏功能之间的相关性。对于RV,E(r=0.735,p<.001),E\'(r=-0.735,p<.001),E/E'(r=0.894,p<.001),与疾病持续时间密切相关。该研究还显示了疾病持续时间与LVE'之间的相关性(r=-0.735,p=0.005),低压E(r=0.750,p<.001),和LVE/E'(r=0.820,p<.001)。
结论:这是第一项评估BD妊娠胎儿心脏功能的研究。虽然BD通常在怀孕期间进展缓解,由于炎症,这些胎儿的心脏可能发生早期亚临床舒张改变。
BACKGROUND: Behcet\'s disease usually progresses with remission during pregnancy, but early subtle changes might be detected in the heart of these fetuses due to inflammation.
OBJECTIVE: We aimed to evaluate the cardiac functions in fetuses of pregnant women with Behcet\'s disease (BD).
METHODS: Prospective case-control study.
METHODS: This prospective study enrolled pregnant women diagnosed with Behcet\'s disease before pregnancy. Twenty-four pregnancies with Behcet\'s disease and 48 healthy pregnancies were included at 32-34 gestational weeks.
METHODS: Pulsed-wave Doppler and tissue Doppler imaging (TDI) were used to assess cardiac functions.
RESULTS: Right ventricle (RV) E (early) wave and left ventricle (LV) E were significantly increased in pregnancies with BD (p = .008, p = .041, respectively). Decreased right ventricle E\' (peak systolic velocity) was detected with TDI in the case group (6.2 ± 0.5, p < .001). E/E\' ratios for RV and LV were significantly increased in the case group (p < .001, p = .001, respectively). The correlation between the duration of the disease and fetal cardiac functions was also evaluated. For RV, E (r = 0.735, p < .001), E\' (r = -0.735, p < .001), E/E\' (r = 0.894, p < .001), were strongly correlated with the disease duration. The study also showed the correlation between disease duration and LV E\' (r = -0.735, p = .005), LV E (r = 0.750, p < .001), and LV E/E\' (r = 0.820, p < .001).
CONCLUSIONS: This is the first study to evaluate the fetal cardiac functions in fetuses of pregnancies with BD. Although BD usually progresses with remission during pregnancy, early subclinical diastolic changes might occur in the heart of these fetuses due to inflammation.