目的:1型糖尿病(T1DM)的特征是胰岛素缺乏。由于感知到的体力活动(PA)相关的低血糖,少数T1DM患者经常锻炼。然而,T1DM和PA之间的关系仍然知之甚少。我们的目的是总结有关PA对T1DM患者短期血糖控制(糖化血红蛋白或时间范围内)影响的现有文献。
方法:我们搜索了七个电子数据库(PubMed,Embase,科克伦图书馆,Cinahl,SPORTDiscus,PEDro和WebOfScience)和灰色文献的两个来源(ClinicalTrials.gov和ICTRP)。所有评论均由两名独立审稿人(LE和HT)通过标题/摘要和全文进行筛选,冲突由第三位独立审查员(DDC)解决。我们排除了动物研究,病例报告,非英语文章,定性研究,没有全文访问的会议摘要和文章。使用随机效应模型进行荟萃分析,以研究PA对T1DM患者血红蛋白A1c(HbA1c)水平的影响。
结果:我们在9个不同的电子数据库中获得了19,201个独特的参考文献。经过筛选和滚雪球,有68篇文章研究了PA对T1DM患者血糖控制的影响。总的来说,PA组的HbA1c水平(平均差异=0.29%(0.20%-0.39%)),低于对照组。
结论:发现PA对T1DM患者血糖控制的总体有益作用较小。在解释本荟萃分析的结果时,建议谨慎,给定研究类型的变化,持续时间,在纳入的研究中,身体活动的频率和强度。
OBJECTIVE: Type 1 diabetes mellitus (T1DM) is characterised by insulin deficiency. Due to perceived physical activity (PA)-related hypoglycaemia, a minority of people with T1DM exercise regularly. However, the relationship between T1DM and PA remains poorly understood. Our aim was to summarise the existing literature on the effects of PA on short-term glucose control (glycated haemoglobin or time in range) in people with T1DM.
METHODS: We searched seven electronic databases (PubMed, Embase, Cochrane library, Cinahl, SPORTDiscus, PEDro and Web Of Science) and two sources of the grey literature (ClinicalTrials.gov and ICTRP). All reviews were screened via title/abstract and full text by two independent reviewers (LE and HT), conflicts were solved by a third independent reviewer (DDC). We excluded animal studies, case reports, non-English articles, qualitative studies, conference abstracts and articles without full-text access. A meta-analysis using random effects model was performed to study the effect of PA on haemoglobin A1c (HbA1c) levels in people with T1DM.
RESULTS: We obtained 19,201 unique references across nine different electronic databases. After screening and snowballing, 68 articles were found investigating the effect of PA on glycaemic control in people with T1DM. Overall, HbA1c levels in the PA group (mean difference = 0.29% (0.20%-0.39%)), were lower compared with the control group.
CONCLUSIONS: An overall small beneficial effect of PA on glycaemic control in people with T1DM was found. Caution is advised when interpreting the results of this meta-analysis, given variations in study type, duration, frequency and intensity of physical activity across included studies.