thirdhand exposure

  • 文章类型: Journal Article
    住宅物业的甲基苯丙胺污染仍然是公众的严重公共卫生问题。包括环境卫生官员(EHO)以及测试和修复技术人员在内的外部利益相关者正在调查是否因制造或吸烟过程而发生污染。更具体地说,当警方通知时,地方议会EHO负责管理秘密药物实验室,并回应公众查询。然而,这些受污染的财产的全部范围没有被任何单一的利益相关者看到,这使得量化这些情况非常具有挑战性。评估公众对EHO的甲基苯丙胺相关查询的患病率,这项研究调查并采访了来自澳大利亚各地的官员.结果发现公众查询很少,只有百分之六的受访者在上月收到查询,这表明人们正在从其他来源寻求信息。有趣的是,有案例研究场景也提到了意识和信息流的问题。对棘手案件的关注,警方通知,还强调了实地考察。这项研究的结果为如何管理与甲基苯丙胺相关的案件提供了一个基准,并强调了对EHO可用的可信赖信息的需求,政府,行业成员,和公众在一个统一的位置。
    Methamphetamine contamination of residential properties remains a serious public health concern for members of the public. External stakeholders including Environmental Health Officers (EHOs) and testing and remediation technicians are engaged on investigating whether contamination has occurred from manufacturing or smoking processes. More specifically, local council EHOs are responsible for managing clandestine drug laboratories when notified by police and also for responding to public enquiries. However, the full scope of these contaminated properties is not seen by any single stakeholder, making it very challenging to quantify these situations. To evaluate the prevalence of methamphetamine related enquiries from the general public to EHOs, this study surveyed and interviewed officers from around Australia. It was found that public enquiries were infrequent with only 6% of respondents having received enquiries in the last month, which indicates that people are seeking information from other sources. Interestingly, there were case study scenarios that also mentioned issues with awareness and the flow of information. Concerns regarding difficult cases, police notifications, and site visits were also highlighted. The results of this study provide a benchmark of how methamphetamine related cases are managed and highlight the need for trustworthy information that is available to EHOs, governments, industry members, and the public in a unified location.
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  • 文章类型: Journal Article
    加味电子烟的广泛使用导致青少年尼古丁使用显着增加。在电子液体中,风味羰基可以形成具有未知化学和毒理学性质的缩醛。这些缩醛通过三手暴露会对吸烟者和非吸烟者造成不利的健康影响。本研究旨在探讨电子烟中形成的这些缩醛对室内分区和三手暴露的影响。具体来说,使用质子核磁共振(1HNMR)光谱法监测实验室制造的电子液体中常用的风味羰基化合物的缩醛化反应。EAS-ESuite和多参数线性自由能关系(PP-LFER)用于估计物种的分配系数。Further,应用化学二维分配模型来可视化室内平衡分配,并估计气相中风味羰基及其缩醛的分布。气溶胶相,和地面水库。我们的结果表明,大部分羰基化合物在电子液体中转化为缩醛,并且它们的化学分配受到显着影响。这项研究表明,缩醛化是有害羰基调味剂暴露和毒理学的决定因素,其影响扩展到直接暴露于吸烟者和非自愿暴露于非吸烟者。
    The widespread use of flavored e-cigarettes has led to a significant rise in teenage nicotine use. In e-liquids, the flavor carbonyls can form acetals with unknown chemical and toxicological properties. These acetals can cause adverse health effects on both smokers and nonsmokers through thirdhand exposure. This study aims to explore the impacts of these acetals formed in e-cigarettes on indoor partitioning and thirdhand exposure. Specifically, the acetalization reactions of commonly used flavor carbonyls in laboratory-made e-liquids were monitored using proton nuclear magnetic resonance (1H NMR) spectroscopy. EAS-E Suite and polyparameter linear free energy relationships (PP-LFERs) were employed to estimate the partitioning coefficients for species. Further, a chemical two-dimensional partitioning model was applied to visualize the indoor equilibrium partitioning and estimate the distribution of flavor carbonyls and their acetals in the gas phase, aerosol phase, and surface reservoirs. Our results demonstrate that a substantial fraction of carbonyls were converted into acetals in e-liquids and their chemical partitioning was significantly influenced. This study shows that acetalization is a determinant factor in the exposure and toxicology of harmful carbonyl flavorings, with its impact extending to both direct exposure to smokers and involuntary exposure to nonsmokers.
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  • 文章类型: Journal Article
    关于非使用者因使用电子蒸汽产品(EVP)而暴露于各种化学品的可能性,目前正在进行辩论。室内空气水平为34种化学物质(尼古丁,丙二醇(PG),甘油,15种羰基化学品,12种挥发性有机化学品(VOCs),和四种选定的微量元素)进行了测量,其中n=37名健康成年烟草使用者在暴露室中使用了EVP和香烟。使用的产品是MarkTen®2.5%Classic(I组),a原型GreenSmoke®2.4%(第二组),Ego-T®Tankwithsubjects\'owne-liquid(GroupIII)andsubjects\'ownconvenientcuttes(GroupIV).在受控条件下使用产品并随意使用4小时。测量背景(无受试者)和基线水平(有受试者)。累积4小时。尼古丁含量,测得的PG和甘油比工作场所暴露评估中使用的时间加权平均限值低几倍。在EVP使用期间,大多数其他化学品(>75%)处于或低于定量极限。在第IV组中观察到显著水平的化学品(34个中的17个)。总的来说,我们的结果表明,在测试产品的研究条件下,在4小时内测量的选定化学品的累积室内空气水平相对较小,比当前的职业法规和共识限值低几倍。
    There is an ongoing debate regarding the potential of secondhand exposure of non-users to various chemicals from use of e-vapor products (EVPs). Room air levels of 34 chemicals (nicotine, propylene glycol (PG), glycerol, 15 carbonyl chemicals, 12 volatile organic chemicals (VOCs), and four selected trace elements) were measured where EVPs and cigarettes were used by n = 37 healthy adult tobacco users in an exposure chamber. The products used were MarkTen® 2.5% Classic (Group I), a Prototype GreenSmoke® 2.4% (Group II), Ego-T® Tank with subjects\' own e-liquids (Group III) and subjects\' own conventional cigarettes (Group IV). Products were used under controlled conditions and 4-h ad libitum use. Background (without subjects) and baseline levels (with subjects) were measured. Cumulative 4-h. levels of nicotine, PG and glycerol measured were several-fold below the time-weighted average limits used in workplace exposure evaluation. Most the other chemicals (>75%) were at or below the limit of quantification during EVP use. Significant levels of chemicals (17 out of 34) were observed in Group IV. Overall, our results indicate that under the study conditions with the products tested, cumulative room air levels of the selected chemicals measured over 4-h were relatively small and were several-fold below the current occupational regulatory and consensus limits.
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  • 文章类型: Comparative Study
    BACKGROUND: Nicotine deposited on the surfaces has been shown to react with airborne chemicals leading to formation of carcinogens and contributing to thirdhand exposure. While prior studies revealed nicotine residues in tobacco smokers\' homes, none have examined the nicotine residue in electronic cigarette (e-cigarette) users\' homes.
    METHODS: We measured nicotine on the surfaces in households of 8 e-cigarette users, 6 cigarette smokers, and 8 non-users of nicotine-containing products in Western New York, USA. Three surface wipe samples were taken from the floor, wall and window. Nicotine was extracted from the wipes and analyzed using gas chromatography.
    RESULTS: Half of the e-cigarette users\' homes had detectable levels of nicotine on surfaces whereas nicotine was found in all of the tobacco cigarette smokers\' homes. Trace amounts of nicotine were also detected in half of the homes of non-users of nicotine-containing products. Nicotine levels in e-cigarette users homes was significantly lower than that found in cigarette smokers homes (average concentration 7.7±17.2 vs. 1303±2676 μg/m2; p<0.05). There was no significant difference in the amount of nicotine in homes of e-cigarette users and non-users (p>0.05).
    CONCLUSIONS: Nicotine is a common contaminant found on indoor surfaces. Using e-cigarettes indoors leads to significantly less thirdhand exposure to nicotine compared to smoking tobacco cigarettes.
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