背景:肝硬化是一种慢性和进行性肝病,对全球健康具有重大影响。最近的证据表明,血清维生素D水平与肝硬化的严重程度之间存在关联,可能作为治疗目标。本研究旨在探讨尼日利亚患者血清维生素D水平与肝硬化严重程度之间的关系。
方法:这种分析,横断面研究涉及201名参与者,包括103名肝硬化患者和98名年龄和性别匹配的对照。血清维生素D采用ELISA检测,缺乏定义为<20ng/ml。使用Child-Pugh和MELD评分评估肝硬化严重程度。Spearman的相关性用于评估维生素D与肝硬化严重程度之间的关系,而有序回归分析评估其作为疾病严重程度指标的表现。
结果:在肝硬化患者中,36.9%有缺陷,不足31.1%,和32.0%有足够的维生素D水平。血清维生素D与Child-Pugh和MELD评分呈显著负相关(r=-0.696,p<0.001;r=-0.734,p<0.001)。有序回归显示较高的维生素D水平与较低的严重程度评分相关(Child-Pugh:OR=0.856,95%CI:0.815-0.900,p<0.001;MELD:OR=0.875,95%CI:0.837-0.915,p<0.001)。
结论:血清维生素D水平降低与肝硬化严重程度增加相关,提示其作为预后标志物和治疗靶点的潜力。进一步的研究应该探讨补充维生素D在改善肝硬化预后中的功效。
BACKGROUND: Liver cirrhosis is a chronic and progressive liver disease with significant global health implications. Recent evidence suggests an association between serum vitamin D levels and the severity of liver cirrhosis, potentially serving as a therapeutic target. This study aimed to investigate the relationship between serum vitamin D status and the severity of liver cirrhosis in a population of Nigerian patients.
METHODS: This analytical, cross-sectional study involved 201 participants, including 103 with liver cirrhosis and 98 age- and sex-matched controls. Serum vitamin D was measured using ELISA, with deficiency defined as < 20 ng/ml. Cirrhosis severity was assessed using Child-Pugh and MELD scores. Spearman\'s correlation was used to assess the relationship between vitamin D and severity of liver cirrhosis while ordinal regression analysis assessed its performance as an indicator of the disease severity.
RESULTS: Among cirrhotic patients, 36.9% were deficient, 31.1% insufficient, and 32.0% had sufficient vitamin D levels. Serum vitamin D showed strong negative correlations with Child-Pugh and MELD scores (r = -0.696, p < 0.001; r = -0.734, p < 0.001, respectively). Ordinal regression showed that higher vitamin D levels were associated with lower severity scores (Child-Pugh: OR = 0.856, 95% CI: 0.815-0.900, p < 0.001; MELD: OR = 0.875, 95% CI: 0.837-0.915, p < 0.001).
CONCLUSIONS: Lower serum vitamin D levels correlated with increased liver cirrhosis severity, suggesting its potential as both a prognostic marker and therapeutic target. Further studies should investigate the efficacy of vitamin D supplementation in improving cirrhosis outcomes.