■经颅交流电刺激(tACS)是一种脑刺激方法,用于在感觉和认知过程中以指定频率调节正在进行的内源性振荡活动。鉴于事件相关电位(ERP)和事件相关振荡(ERO)之间的重叠,ERP可以作为认知/感觉任务表现期间tACS在大脑中的影响的推定生物标志物进行研究。
■这项初步研究旨在测试基于提示的过早响应任务中引起的个体P3(潜伏期和频率)单独定制的tACS的可行性。因此,tACS频率是单独定制的,以匹配每个参与者的目标-P3ERO。同样,调整了任务中的目标起始时间以匹配tACS阶段和目标P3潜伏期.
■12名健康志愿者在执行过早响应任务的同时,在两个单独的会议中接受了tACS。在第一个会话期间,在基线阻滞中计算了Target-P3潜伏期和ERO,以允许tACS和内源性振荡活动之间的后验同步。提示和目标P3振幅,delta/thetaERO,和功率谱密度(PSD)在tACS模块之前和之后进行评估。
■目标P3振幅在activetACS后显著增加,与假相比。tACS后提示P3期间的诱发δ减少。在目标P3期间没有发现deltaERO的影响,也没有发现PSD和行为结果的影响。
■本研究结果强调了个性化tACS参数和内源性振荡活动之间的相位同步的可能影响,这可能会导致底层过程的增强(即,目标P3的增加)。然而,tACS和EEG活动之间的不成功同步也可能导致cue-P3期间的诱发δ活动减少。需要进一步的研究来优化内源性活动和tACS同步的参数。当前结果对未来研究的影响,包括临床研究,进一步讨论,因为经颅交流刺激可以基于内源性事件相关P3单独定制以调节反应。
UNASSIGNED: Transcranial alternating current stimulation (
tACS) is a brain stimulation method for modulating ongoing endogenous oscillatory activity at specified frequency during sensory and cognitive processes. Given the overlap between event-related potentials (ERPs) and event-related oscillations (EROs), ERPs can be studied as putative biomarkers of the effects of
tACS in the brain during cognitive/sensory task performance.
UNASSIGNED: This preliminary study aimed to test the feasibility of individually tailored tACS based on individual P3 (latency and frequency) elicited during a cued premature response task. Thus,
tACS frequency was individually tailored to match target-P3 ERO for each participant. Likewise, the target onset in the task was adjusted to match the
tACS phase and target-P3 latency.
UNASSIGNED: Twelve healthy volunteers underwent tACS in two separate sessions while performing a premature response task. Target-P3 latency and ERO were calculated in a baseline block during the first session to allow a posterior synchronization between the tACS and the endogenous oscillatory activity. The cue and target-P3 amplitudes, delta/theta ERO, and power spectral density (PSD) were evaluated pre and post-tACS blocks.
UNASSIGNED: Target-P3 amplitude significantly increased after activetACS, when compared to sham. Evoked-delta during cue-P3 was decreased after
tACS. No effects were found for delta ERO during target-P3 nor for the PSD and behavioral outcomes.
UNASSIGNED: The present findings highlight the possible effect of phase synchronization between individualized tACS parameters and endogenous oscillatory activity, which may result in an enhancement of the underlying process (i.e., an increase of target-P3). However, an unsuccessful synchronization between tACS and EEG activity might also result in a decrease in the evoked-delta activity during cue-P3. Further studies are needed to optimize the parameters of endogenous activity and tACS synchronization. The implications of the current results for future studies, including clinical studies, are further discussed since transcranial alternating current stimulation can be individually tailored based on endogenous event-related P3 to modulate responses.