■益神娟必(YSJB)丸已用于治疗类风湿性关节炎(RA),一些研究报告了其抗炎作用和预防骨破坏的能力。然而,缺乏有关YSJB各组分的有效性和毒性的证据限制了其广泛使用.
■本方案概述了评估YSJB有效性和安全性的系统回顾和/或荟萃分析。
■我们将搜索全球电子数据库,包括MEDLINE,科克伦图书馆,中国国家知识基础设施,万方,CINII,J-STAGE,KoreaMed,韩国医学数据库,韩国研究信息服务系统,国家数字科学图书馆,韩国科学技术信息研究所,和东方医学高级搜索集成系统。此外,我们将进行手动搜索,and,如有必要,直接联系作者搜索将涵盖2024年6月之前的出版物。
■我们将选择比较使用YSJB治疗RA与其他治疗方法的随机对照试验(RCT)。
■将从选定的RCT中提取数据,包括样本量,患者特征,干预细节,和结果措施。我们将使用ReviewManager软件进行荟萃分析。
■主要结果指标将包括疾病活动评分,例如有效率,肿胀的关节计数,招标接头计数,和早晨的僵硬。次要结果指标将包括血液检测结果和不良事件。
■结果将揭示YSJB治疗RA的有效性和安全性。
■和相关性:研究结果将为RA.S.使用YSJB提供基于证据的审查
UNASSIGNED: The Yi Shen Juan Bi (YSJB) pill has been used to treat rheumatoid arthritis (RA), with several studies reporting its anti-inflammatory effects and ability to prevent bone destruction. However, the lack of evidence regarding the effectiveness and toxicity of individual components of YSJB limits its widespread use.
UNASSIGNED: This protocol outlines a systematic review and/or meta-analysis to evaluate the effectiveness and safety of YSJB.
UNASSIGNED: We will search worldwide electronic databases, including MEDLINE, Cochrane Library, China National Knowledge Infrastructure, Wanfang, CiNii, J-STAGE, KoreaMed, Korean Medical Database, Korean Studies Information Service System, National Digital Science Library, Korea Institute of Science and Technology Information, and Oriental Medicine Advanced Searching Integrated System. In addition, we will conduct manual searches, and, if necessary, contact authors directly. The search will cover publications until June 2024.
UNASSIGNED: We will select randomized controlled trials (RCTs) that compare the use of YSJB for the treatment of RA against other treatments.
UNASSIGNED: Data from the selected RCTs will be extracted, including sample size, patient characteristics, intervention details, and outcome measures. We will perform a meta-analysis using Review Manager software.
UNASSIGNED: The primary outcome measures will include disease activity scores such as effective rate, swollen joint count, tender joint count, and morning stiffness. Secondary outcome measures will include blood test results and adverse events.
UNASSIGNED: The results will reveal the effectiveness and safety of YSJB for the treatment of RA.
UNASSIGNED: and Relevance: The findings will provide an evidence-based review of the use of YSJB for RA.S.