目的:最近研究的精神分裂症全身炎症生物标志物包括中性粒细胞/淋巴细胞比值(NLR),单核细胞/淋巴细胞比率(MLR),血小板/淋巴细胞比率(PLR),全身免疫炎症指数(SII),全身炎症反应指数(SIRI)。SIRI,一种新的炎症标记,尚未在精神分裂症的不同阶段进行研究。我们的目的是比较NLR,MLR,PLR,SII,相同精神分裂症患者和健康对照组的精神病加重和缓解值之间的SIRI值。方法:在这项研究中,86例精神分裂症患者因精神病复发而住院,治疗后缓解的相同患者组,并对86名年龄性别匹配的健康对照受试者进行分析。分析了患者组在精神病加重(PE)和缓解期(R)的炎症标志物值,并与健康对照组(HC)进行了比较。结果:NLR,MLR,PLR,SII,精神分裂症-PE组的SIRI值明显高于HC组。NLR,MLR,SII,精神分裂症-PE组的SIRI值明显高于精神分裂症-R组。精神分裂症-R组的MLR值明显高于HC组。结论:这些发现可以解释为NLR,SII,和SIRI,可以被认为是状态生物标志物,和MLR可能是精神分裂症的性状标记。
UNASSIGNED: Systemic inflammatory biomarkers recently studied in schizophrenia include neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI). SIRI, a novel inflammatory marker, has not been studied in different stages of schizophrenia. We aimed to compare NLR, MLR, PLR, SII, and SIRI values between psychotic exacerbation and remission values of the same patients with schizophrenia and a healthy control group.
UNASSIGNED: In this study, 86 patients with schizophrenia who were hospitalized due to psychotic relapse, the same patient group who were in remission after treatment, and 86 age-sex-matched healthy control subjects were analyzed. Inflammatory marker values of the patient group in both the psychotic exacerbation (PE) and the remission (R) period were analyzed and compared with healthy controls (HC).
UNASSIGNED: NLR, MLR, PLR, SII, and SIRI values were significantly higher in the schizophrenia-PE group than in the HC group. NLR, MLR, SII, and SIRI values were significantly higher in the schizophrenia-PE group than in the schizophrenia-R group. MLR values were significantly higher in the schizophrenia-R group than in the HC group.
UNASSIGNED: These findings may be interpreted as NLR, SII, and SIRI, which may be considered as state biomarkers, and MLR may be a trait marker for schizophrenia.