The interpretability of gait analysis studies in people with rare diseases, such as those with primary hereditary cerebellar ataxia (pwCA), is frequently limited by the small sample sizes and unbalanced datasets. The purpose of this study was to assess the effectiveness of data balancing and generative artificial intelligence (AI) algorithms in generating synthetic data reflecting the actual gait abnormalities of pwCA. Gait data of 30 pwCA (age: 51.6 ± 12.2 years; 13 females, 17 males) and 100 healthy subjects (age: 57.1 ± 10.4; 60 females, 40 males) were collected at the lumbar level with an inertial measurement unit. Subsampling, oversampling, synthetic minority oversampling, generative adversarial networks, and conditional tabular generative adversarial networks (ctGAN) were applied to generate datasets to be input to a random forest classifier. Consistency and explainability metrics were also calculated to assess the coherence of the generated dataset with known gait abnormalities of pwCA. ctGAN significantly improved the classification performance compared with the original dataset and traditional data augmentation methods. ctGAN are effective methods for balancing tabular datasets from populations with rare diseases, owing to their ability to improve diagnostic models with consistent explainability.

BACKGROUND: Postoperative delirium, particularly prevalent in elderly patients after abdominal cancer surgery, presents significant challenges in clinical management.
OBJECTIVE: To develop a synthetic minority oversampling technique (SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer patients.
METHODS: In this retrospective cohort study, we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October 2022. The incidence of postoperative delirium was recorded for 7 d post-surgery. Patients were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not. A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative delirium. The SMOTE technique was applied to enhance the model by oversampling the delirium cases. The model\'s predictive accuracy was then validated.
RESULTS: In our study involving 611 elderly patients with abdominal malignant tumors, multivariate logistic regression analysis identified significant risk factors for postoperative delirium. These included the Charlson comorbidity index, American Society of Anesthesiologists classification, history of cerebrovascular disease, surgical duration, perioperative blood transfusion, and postoperative pain score. The incidence rate of postoperative delirium in our study was 22.91%. The original predictive model (P1) exhibited an area under the receiver operating characteristic curve of 0.862. In comparison, the SMOTE-based logistic early warning model (P2), which utilized the SMOTE oversampling algorithm, showed a slightly lower but comparable area under the curve of 0.856, suggesting no significant difference in performance between the two predictive approaches.
CONCLUSIONS: This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of traditional methods, effectively addressing data imbalance.

Heart disease is a major global cause of mortality and a major public health problem for a large number of individuals. A major issue raised by regular clinical data analysis is the recognition of cardiovascular illnesses, including heart attacks and coronary artery disease, even though early identification of heart disease can save many lives. Accurate forecasting and decision assistance may be achieved in an effective manner with machine learning (ML). Big Data, or the vast amounts of data generated by the health sector, may assist models used to make diagnostic choices by revealing hidden information or intricate patterns. This paper uses a hybrid deep learning algorithm to describe a large data analysis and visualization approach for heart disease detection. The proposed approach is intended for use with big data systems, such as Apache Hadoop. An extensive medical data collection is first subjected to an improved k-means clustering (IKC) method to remove outliers, and the remaining class distribution is then balanced using the synthetic minority over-sampling technique (SMOTE). The next step is to forecast the disease using a bio-inspired hybrid mutation-based swarm intelligence (HMSI) with an attention-based gated recurrent unit network (AttGRU) model after recursive feature elimination (RFE) has determined which features are most important. In our implementation, we compare four machine learning algorithms: SAE + ANN (sparse autoencoder + artificial neural network), LR (logistic regression), KNN (K-nearest neighbour), and naïve Bayes. The experiment results indicate that a 95.42% accuracy rate for the hybrid model\'s suggested heart disease prediction is attained, which effectively outperforms and overcomes the prescribed research gap in mentioned related work.

This research leverages a novel deep learning model, Inception-v3, to predict pedestrian crash severity using data collected over five years (2016-2021) from Louisiana. The final dataset incorporates forty different variables related to pedestrian attributes, environmental conditions, and vehicular specifics. Crash severity was classified into three categories: fatal, injury, and no injury. The Boruta algorithm was applied to determine the importance of variables and investigate contributing factors to pedestrian crash severity, revealing several associated aspects, including pedestrian gender, pedestrian and driver impairment, posted speed limits, alcohol involvement, pedestrian age, visibility obstruction, roadway lighting conditions, and both pedestrian and driver conditions, including distraction and inattentiveness. To address data imbalance, the study employed Random Under Sampling (RUS) and the Synthetic Minority Oversampling Technique (SMOTE). The DeepInsight technique transformed numeric data into images. Subsequently, five crash severity prediction models were developed with Inception-v3, considering various scenarios, including original, under-sampled, over-sampled, a combination of under and over-sampled data, and the top twenty-five important variables. Results indicated that the model applying both over and under sampling outperforms models based on other data balancing techniques in terms of several performance metrics, including accuracy, sensitivity, precision, specificity, false negative ratio (FNR), false positive ratio (FPR), and F1-score. This model achieved prediction accuracies of 93.5%, 77.5%, and 85.9% for fatal, injury, and no injury categories, respectively. Additionally, comparative analysis based on several performance metrics and McNemar\'s tests demonstrated that the predictive performance of the Inception-v3 deep learning model is statistically superior compared to traditional machine learning and statistical models. The insights from this research can be effectively harnessed by safety professionals, emergency service providers, traffic management centers, and vehicle manufacturers to enhance their safety measures and applications.

Time-consuming data labeling in brain-computer interfaces (BCIs) raises many problems such as mental fatigue and is one key factor that hinders the real-world adoption of motor imagery (MI)-based BCIs. An alternative approach is to integrate readily available, as well as informative, unlabeled data online, whereas this approach is less investigated.
We proposed an online semi-supervised learning scheme to improve the classification performance of MI-based BCI. This scheme uses regularized weighted online sequential extreme learning machine (RWOS-ELM) as the base classifier and updates its model parameters with incoming balanced data chunk-by-chunk. In the initial stage, we designed a technique that combines the synthetic minority oversampling with the edited nearest neighbor rule for data augmentation to construct more discriminative initial classifiers. When used online, the incoming chunk of data is first pseudo-labeled by RWOS-ELM as well as an auxiliary classifier, and then balanced again by the above-mentioned technique. Initial classifiers are further updated based on these class-balanced data.
Offline experimental results on two publicly available MI datasets demonstrate the superiority of the proposed scheme over its counterparts. Further online experiments on six subjects show that their BCI performance gradually improved by learning from incoming unlabeled data.
Our proposed online semi-supervised learning scheme has higher computation and memory usage efficiency, which is promising for online MI-based BCIs, especially in the case of insufficient labeled training data.

This work provides an innovative endodontic instrument fault detection methodology during root canal treatment (RCT). Sometimes, an endodontic instrument is prone to fracture from the tip, for causes uncertain the dentist\'s control. A comprehensive assessment and decision support system for an endodontist may avoid several breakages. This research proposes a machine learning and artificial intelligence-based approach that can help to diagnose instrument health. During the RCT, force signals are recorded using a dynamometer. From the acquired signals, statistical features are extracted. Because there are fewer instances of the minority class (i.e. faulty/moderate class), oversampling of datasets is required to avoid bias and overfitting. Therefore, the synthetic minority oversampling technique (SMOTE) is employed to increase the minority class. Further, evaluating the performance using the machine learning techniques, namely Gaussian Naïve Bayes (GNB), quadratic support vector machine (QSVM), fine k-nearest neighbor (FKNN), and ensemble bagged tree (EBT). The EBT model provides excellent performance relative to the GNB, QSVM, and FKNN. Machine learning (ML) algorithms can accurately detect endodontic instruments\' faults by monitoring the force signals. The EBT and FKNN classifier is trained exceptionally well with an area under curve values of 1.0 and 0.99 and prediction accuracy of 98.95 and 97.56%, respectively. ML can potentially enhance clinical outcomes, boost learning, decrease process malfunctions, increase treatment efficacy, and enhance instrument performance, contributing to superior RCT processes. This work uses ML methodologies for fault detection of endodontic instruments, providing practitioners with an adequate decision support system.

Real-time polymerase chain reaction (RT-PCR) known as the swab test is a diagnostic test that can diagnose COVID-19 disease through respiratory samples in the laboratory. Due to the rapid spread of the coronavirus around the world, the RT-PCR test has become insufficient to get fast results. For this reason, the need for diagnostic methods to fill this gap has arisen and machine learning studies have started in this area. On the other hand, studying medical data is a challenging area because the data it contains is inconsistent, incomplete, difficult to scale, and very large. Additionally, some poor clinical decisions, irrelevant parameters, and limited medical data adversely affect the accuracy of studies performed. Therefore, considering the availability of datasets containing COVID-19 blood parameters, which are less in number than other medical datasets today, it is aimed to improve these existing datasets. In this direction, to obtain more consistent results in COVID-19 machine learning studies, the effect of data preprocessing techniques on the classification of COVID-19 data was investigated in this study. In this study primarily, encoding categorical feature and feature scaling processes were applied to the dataset with 15 features that contain blood data of 279 patients, including gender and age information. Then, the missingness of the dataset was eliminated by using both K-nearest neighbor algorithm (KNN) and chain equations multiple value assignment (MICE) methods. Data balancing has been done with synthetic minority oversampling technique (SMOTE), which is a data balancing method. The effect of data preprocessing techniques on ensemble learning algorithms bagging, AdaBoost, random forest and on popular classifier algorithms KNN classifier, support vector machine, logistic regression, artificial neural network, and decision tree classifiers have been analyzed. The highest accuracies obtained with the bagging classifier were 83.42% and 83.74% with KNN and MICE imputations by applying SMOTE, respectively. On the other hand, the highest accuracy ratio reached with the same classifier without SMOTE was 83.91% for the KNN imputation. In conclusion, certain data preprocessing techniques are examined comparatively and the effect of these data preprocessing techniques on success is presented and the importance of the right combination of data preprocessing to achieve success has been demonstrated by experimental studies.

Deep learning-based fault diagnosis usually requires a rich supply of data, but fault samples are scarce in practice, posing a considerable challenge for existing diagnosis approaches to achieve highly accurate fault detection in real applications. This paper proposes an imbalanced fault diagnosis of rotatory machinery that combines time-frequency feature oversampling (TFFO) with a convolutional neural network (CNN). First, the sliding segmentation sampling method is employed to primarily increase the number of fault samples in the form of one-dimensional signals. Immediately after, the signals are converted into two-dimensional time-frequency feature maps by continuous wavelet transform (CWT). Subsequently, the minority samples are expanded again using the synthetic minority oversampling technique (SMOTE) to realize TFFO. After such two-fold data expansion, a balanced data set is obtained and imported to an improved 2dCNN based on the LeNet-5 to implement fault diagnosis. In order to verify the proposed method, two experiments involving single and compound faults are conducted on locomotive wheel-set bearings and a gearbox, resulting in several datasets with different imbalanced degrees and various signal-to-noise ratios. The results demonstrate the advantages of the proposed method in terms of classification accuracy and stability as well as noise robustness in imbalanced fault diagnosis, and the fault classification accuracy is over 97%.

Methods to correct class imbalance (imbalance between the frequency of outcome events and nonevents) are receiving increasing interest for developing prediction models. We examined the effect of imbalance correction on the performance of logistic regression models.
Prediction models were developed using standard and penalized (ridge) logistic regression under 4 methods to address class imbalance: no correction, random undersampling, random oversampling, and SMOTE. Model performance was evaluated in terms of discrimination, calibration, and classification. Using Monte Carlo simulations, we studied the impact of training set size, number of predictors, and the outcome event fraction. A case study on prediction modeling for ovarian cancer diagnosis is presented.
The use of random undersampling, random oversampling, or SMOTE yielded poorly calibrated models: the probability to belong to the minority class was strongly overestimated. These methods did not result in higher areas under the ROC curve when compared with models developed without correction for class imbalance. Although imbalance correction improved the balance between sensitivity and specificity, similar results were obtained by shifting the probability threshold instead.
Imbalance correction led to models with strong miscalibration without better ability to distinguish between patients with and without the outcome event. The inaccurate probability estimates reduce the clinical utility of the model, because decisions about treatment are ill-informed.
Outcome imbalance is not a problem in itself, imbalance correction may even worsen model performance.

The survival of mankind cannot be imagined without air. Consistent developments in almost all realms of modern human society affected the health of the air adversely. Daily industrial, transport, and domestic activities are stirring hazardous pollutants in our environment. Monitoring and predicting air quality have become essentially important in this era, especially in developing countries like India. In contrast to the traditional methods, the prediction technologies based on machine learning techniques are proved to be the most efficient tools to study such modern hazards. The present work investigates six years of air pollution data from 23 Indian cities for air quality analysis and prediction. The dataset is well preprocessed and key features are selected through the correlation analysis. An exploratory data analysis is exercised to develop insights into various hidden patterns in the dataset and pollutants directly affecting the air quality index are identified. A significant fall in almost all pollutants is observed in the pandemic year, 2020. The data imbalance problem is solved with a resampling technique and five machine learning models are employed to predict air quality. The results of these models are compared with the standard metrics. The Gaussian Naive Bayes model achieves the highest accuracy while the Support Vector Machine model exhibits the lowest accuracy. The performances of these models are evaluated and compared through established performance parameters. The XGBoost model performed the best among the other models and gets the highest linearity between the predicted and actual data.