随着移动通信技术的发展,作为远程医疗的重要组成部分,智能手机已被用于即时医疗技术(POCT)。采用多学科设计原理耦合电气工程,软件开发,合成生物学,光遗传学,研究人员开发了一种智能手机控制的半自动治疗诊断系统,该系统以超剂量控制的方式调节糖尿病小鼠的血糖稳态.本章描述了研究人员如何量身定制植入物结构\"HydrogeLED,“它能够携带设计师细胞携带的藻酸盐水凝胶和无线供电的远红光LED。使用糖尿病作为模型疾病,来自HydrogeLED植入物的胰岛素或人胰高血糖素样肽1(shGLP-1)的体内表达不仅可以通过预先设定的ECNU-TeleMed程序来控制,而且还通过定制设计的蓝牙主动血糖仪以半自动和血糖依赖的方式进行。因此,通过智能手机控制的半自动治疗诊断系统,糖尿病小鼠可半自动维持血糖稳态.通过结合数字信号和光基因工程细胞,本研究为疾病的综合诊断和治疗提供了新的方法。
With the development of mobile communication technology, smartphones have been used in point-of-care technologies (POCTs) as an important part of telemedicine. Using a multidisciplinary design principle coupling electrical engineering, software development, synthetic biology, and optogenetics, the investigators developed a smartphone-controlled semiautomatic theranostic system that regulates blood glucose homeostasis in diabetic mice in an ultraremote-control manner. The present chapter describes how the investigators tailor-designed the implant architecture \"HydrogeLED,\" which is capable of coharboring a designer-cell-carrying alginate hydrogel and wirelessly powered far-red light LEDs. Using diabetes mellitus as a model disease, the in vivo expression of insulin or human glucagon-like peptide 1 (shGLP-1) from HydrogeLED implants could be controlled not only by pre-set ECNU-TeleMed programs, but also by a custom-engineered Bluetooth-active glucometer in a semiautomatic and glycemia-dependent manner. As a result, blood glucose homeostasis was semiautomatically maintained in diabetic mice through the smartphone-controlled semiautomatic theranostic system. By combining digital signals with optogenetically engineered cells, the present study provides a new method for the integrated diagnosis and treatment of diseases.