目的:本研究的目的是使用扫描源光学相干断层扫描(SS-OCT)评估拉坦前列素对新诊断的原发性开角型青光眼患者脉络膜厚度的影响。
方法:回顾性研究,非随机研究包括40例新诊断的原发性开角型青光眼患者接受拉坦前列素治疗(第1组).此外,40名年龄和性别匹配的健康受试者作为对照组(组2)。使用SS-OCT,凹下的测量,水平时间,和水平的鼻象限脉络膜厚度,以及眼压(IOP)和视网膜神经纤维层(RNFL)厚度值,在基线和1个月后收集两组。
结果:第1组的平均年龄为39.8±4.15岁(范围:18-45岁),第2组的平均年龄为41.67±7.95岁(范围:18-45岁)(p>0.05)。中央凹区域的平均脉络膜厚度,水平时间象限,拉坦前列素治疗前的水平鼻象限为263.57±84.23μm,233.05±80.08μm,第一组为219.52±83.28μm,而第一组为278.9±93.88μm,第2组243.8±73.37μm和209.85±92.92μm。拉坦前列素治疗后,中央凹区域的平均脉络膜厚度,水平时间象限,水平鼻象限显著变化为299.77±41.29μm,269.9±43.80μm,在第1组中为261.32±45.60μm(分别为p=0.02,p=0.016和p=0.012)(表1)。然而,中央凹区域的平均脉络膜厚度,第2组的水平颞象限和水平鼻象限变化不明显,为279.25±103.37μm,246.42±87.07μm和203.62±106.74μm,分别(p=0.4,p=0.5和p=0.9,分别)。第1组的平均眼压显著下降(p=0.000),但第2组没有显著变化(p=0.153)。第1组和第2组基线和第1个月的RNFL厚度值无差异(p>0.05)。
结论:外用拉坦前列素可增加脉络膜厚度。扫描源OCT可能有助于我们理解拉坦前列素对脉络膜厚度的作用。
OBJECTIVE: The purpose of this study was to assess the influence of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma using Swept-Source Optical Coherence Tomography (SS-OCT).
METHODS: The retrospective, non-randomized study comprised 40 newly diagnosed primary open-angle glaucoma patients receiving latanoprost therapy (Group 1). Additionally, 40 age- and sex-matched healthy subjects served as the control group (Group 2). Using SS-OCT, measurements of subfoveal, horizontal temporal, and horizontal nasal quadrants choroidal thickness, as well as intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness values, were collected at baseline and after 1 month for both groups.
RESULTS: The mean age was 39.8±4.15 years (range: 18-45 years) in group 1 and 41.67±7.95 years (range: 18-45 years) in group 2 (p>0.05). The mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant prior to latanoprost therapy were 263.57±84.23 μm, 233.05±80.08 μm, and 219.52±83.28 μm in the group 1 whereas 278.9±93.88 μm, 243.8±73.37 μm and 209.85±92.92 μm in the group 2. After latanoprost therapy, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant changed significantly to 299.77±41.29 μm, 269.9±43.80 μm, and 261.32±45.60 μm in the group 1 (p=0.02, p=0.016, and p=0.012, respectively) (Table 1). However, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant and horizontal nasal quadrant in group 2 changed not significant and was 279.25±103.37 μm, 246.42±87.07 μm and 203.62±106.74 μm, respectively (p=0.4, p=0.5 and p=0.9, respectively). The mean IOP decreased significantly in group 1 (p=0.000) but did not change significantly in group 2 (p=0.153). There was no difference in RNFL thickness values at baseline and 1 st month in group 1 and group 2 (p>0.05).
CONCLUSIONS: Topical latanoprost may increase choroidal thickness. Swept Source-OCT may contribute to our understanding of the actions of latanoprost on choroidal thickness.