原发性震颤(ET)是最常见的运动障碍之一。ET的临床异质性研究已有多年,然而,几乎没有全面的研究致力于评估与ET患者存在的运动和非运动障碍严重程度相关的生化和电生理参数,并考虑其异质性.
本报告的目的是使用临床聚类分析来区分特发性震颤的亚组,生化和电生理参数。
该研究招募了90名ET患者。对人口统计数据进行聚类,FTMS量表得分,ADL,MoCA,Beka,表面肌电图数据,血清IL-1β水平,IL-6,IL-8,IL-10,TNFα,尿酸,铜蓝蛋白,MDA。
根据对运动表现严重程度的分析,心理情绪状态,患者的适应性潜力和发病机理的生化方面,确定了三个相对均匀的ET簇。
揭示特发性震颤的异质性可以进一步理解疾病的发病机理。
Essential tremor (ET) is one of the most common movement disorders. The clinical heterogeneity of ET has been studied for many years, however, there are practically no comprehensive studies dedicated to the assessment of biochemical and electrophysiological parameters associated with the severity of motor and non-motor disorders present in patients with ET and taking into account their heterogeneity.
The objective of this report is to differentiate subgroups of essential tremor using cluster analysis of clinical, biochemical and electrophysiological parameters.
The study enrolled 90 patients with ET. Clustering was perform on the demographic data, scores of scales FTMS, ADL, MoCA, Beka, surface electromyographic data, levels of serum IL-1β, IL-6, IL-8, IL-10, TNFα, uric acid, ceruloplasmin, MDA.
Based on the analysis of the severity of motor manifestations, the psychoemotional state, the adaptive potential of patients and the biochemical aspects of the pathogenesis, three relatively homogeneous clusters of ET were identified.
Revealing the heterogeneity of essential tremor allows to expand understanding the pathogenesis of disease.