■主观认知功能下降(SCD)与淀粉样蛋白水平升高和未来认知功能下降的风险增加有关,以及可修改的变量,包括抑郁症,焦虑,缺乏体力活动。参与者通常比他们亲密的家人和朋友(研究伙伴[SP])更多和更早的关注,这可能反映了潜在神经退行性过程参与者在疾病早期阶段的微妙变化。然而,许多有主观顾虑的人没有患阿尔茨海默病(AD)病理的风险,这表明额外的因素,比如生活习惯,可能是有贡献的。
■我们检查了SCD,淀粉样蛋白状态,生活习惯(锻炼,sleep),情绪/焦虑,和人口统计学变量在4481名接受多站点二级预防试验筛查的认知未受损的老年人中(A4屏幕数据;平均值±SD:年龄=71.3±4.7,教育程度=16.6±2.8,59%女性,96%的非西班牙裔或拉丁裔,92%白色]。
■在认知功能指数(CFI)上,与SP相比,参与者认可了更高的担忧。参与者的担忧与年龄有关,淀粉样蛋白阳性,更糟糕的情绪/焦虑,教育水平较低,和较低的锻炼,而SP问题与年龄较大的参与者有关,参与者的男性性别,参与者的淀粉样蛋白呈阳性,以及更差的参与者报告的情绪/焦虑。
■研究结果表明,可改变的/生活方式因素(例如,锻炼,教育)可能与认知未受损个体中的参与者关注相关,并强调进一步研究可修改因素如何影响参与者和SP报告的关注的重要性,这可能为试验招募和临床干预提供信息。
UNASSIGNED: Subjective cognitive decline (SCD) has been associated with elevated amyloid levels and increased risk of future cognitive decline, as well as modifiable variables, including depression, anxiety, and physical inactivity. Participants generally endorse greater and earlier concerns than their close family and friends (study partners [SPs]), which may reflect subtle changes at the earliest stages of disease among participants with underlying neurodegenerative processes. However, many individuals with subjective concerns are not at risk of Alzheimer\'s disease (AD) pathology, suggesting that additional factors, such as lifestyle habits, may be contributory.
UNASSIGNED: We examined the relation between SCD, amyloid status, lifestyle habits (exercise, sleep), mood/anxiety, and demographic variables among 4481 cognitively unimpaired older adults who are being screened for a multi-site secondary prevention trial (A4 screen data; mean ±SD: age = 71.3 ±4.7, education = 16.6 ±2.8, 59% women, 96% non-Hispanic or Latino, 92% White].
UNASSIGNED: On the Cognitive Function Index (CFI) participants endorsed higher concerns compared to SPs. Participant concerns were associated with older age, positive amyloid status, worse mood/anxiety, lower education, and lower exercise, whereas SP concerns were associated with older participant age, male gender of participant, positive amyloid status of participant, and worse participant-reported mood/anxiety.
UNASSIGNED: Findings suggest that modifiable/lifestyle factors (e.g., exercise, education) may be associated with participant concerns among cognitively unimpaired individuals and highlight the importance of further examining how modifiable factors impact participant- and SP-reported concerns, which may inform trial recruitment and clinical interventions.