背景:心肌功(MW)是一种新颖的超声心动图模式,已被证明对心血管疾病患者具有诊断和预后价值,阻塞性冠状动脉疾病患者,特别是。然而,只有少数研究检查了非阻塞性冠状动脉缺血(INOCA)的MW分析.这项研究,因此,旨在检测通过进行MW分析的有创冠状动脉造影诊断的INOCA患者的早期左心室受累。
方法:本研究共纳入119例经有创冠状动脉造影诊断的非阻塞性冠心病患者,进行心肌灌注闪烁显像检查的先前缺血测试。在这119名患者中,49例患者出现缺血(即,缺血组)使用心脏单光子发射计算机断层扫描诊断,而70名患者没有(即,非缺血组)。根据全球MW三元率将受试者分为三组。两组在常规方面进行比较,纵向应变,和通过进行超声心动图检查发现的MW。
结果:根据全局收缩功(GCW)值将研究对象分为三组。三组患者的平均年龄无统计学差异(53.0±12vs.52.4±13.3vs.52.1±12.3;p=0.96)。此外,三组在性别方面没有统计学差异,高度,体重,和除白蛋白外的患者的实验室参数。在心腔的测量中,GCW组的三分位数之间没有统计学差异,LA直径,室间隔,E波,一个波浪。此外,组织多普勒记录无统计学差异。检查了与MW相关的参数,三组的整体废物工作量(GWW)无统计学差异(分别为116±92,122±73,135±62,p=0.52).相比之下,三组的全球工作指数(GWI)不同(分别为1716±300,1999±130,2253±195,p<0.001),GCW(分别为1888±206,2298±75,2614±155,p<0.001),和全球工作效率参数(分别为92.8±3.6、94.4±3.2、95.1±1.8p=0.004)。
结论:可以得出结论,MW参数GCW和GWI可能已用于预测患者的INOCA。
BACKGROUND: Myocardial work (MW) is a novel echocardiographic modality, which has been shown to have diagnostic and prognostic values in patients with cardiovascular diseases, patients with obstructive coronary artery disease, in particular. However, only a handful of studies have examined the MW analysis in ischemia with nonobstructive coronary artery (INOCA) disease. This study, therefore, aimed to detect the early left ventricular involvement in INOCA patients diagnosed by an invasive coronary angiography performing the MW analysis.
METHODS: This study included a total of 119 patients with nonobstructive coronary artery disease diagnosed by invasive coronary angiography, who were checked for prior ischemia tests performing myocardial perfusion scintigraphy. Out of these 119 patients, 49 patients developed ischemia (i.e., ischemic group) diagnosed using cardiac single-photon emission computed tomography, whereas 70 patients did not (i.e., nonischemic group). The subjects were divided into three groups based on the global MW tertiles. The groups were compared in terms of the conventional, longitudinal strain, and MW findings by conducting echocardiographic examinations.
RESULTS: The study subjects were divided into three groups based on the global constrictive work (GCW) value. The three groups were not statistically different in terms of the mean age of the patients (53.0 ± 12 vs. 52.4 ± 13.3 vs. 52.1 ± 12.3; p = 0.96). Furthermore, the three groups were not statistically different regarding the gender, height, weight, and laboratory parameters of the patients except albumin. There was no statistically difference among the tertiles of GCW groups in the measurements of cardiac chambers, LA diameter, interventricular septum, E wave, and A wave. Also, there was no statistical difference in tissue Doppler recordings. The parameters associated with MW were examined, three groups were not statistically different in terms of the global waste work (GWW) (116 ± 92, 122 ± 73, 135 ± 62, p = 0.52, respectively). In contrast, the three groups were different regarding the Global work index (GWI) (1716 ± 300, 1999 ± 130, 2253 ± 195, p < 0.001, respectively), GCW (1888 ± 206, 2298 ± 75, 2614 ± 155, p < 0.001, respectively), and Global work efficiency parameters (92.8 ± 3.6, 94.4 ± 3.2, 95.1 ± 1.8 p = 0.004, respectively).
CONCLUSIONS: It was concluded that the MW parameters GCW and GWI may have been used for predicting INOCA in patients.