■类似于成瘾性障碍,认知控制缺陷可能与暴饮暴食症(BED)的发生和发展有关。然而,目前尚不清楚一般或食物相关的抑制控制损害是否与暴饮暴食和暴饮暴食行为基本相关。因此,本研究旨在研究暴饮暴食行为个体中与食物相关的抑制控制的行为表现和电生理相关性。
■使用典型的停止信号任务评估了60名可能BED(pBED)和60名匹配良好的健康对照(HCs)的个体,修订后的Go/NoGo任务,和食物相关的Go/NoGo任务。此外,另一个单独的样本,包括35名pBED和35名HCs,当用事件相关电位(ERP)记录EEG信号时,完成了与食物相关的Go/NoGo任务。
■数据显示,与HC相比,pBED组在停止信号任务的SSRT更长的情况下表现较差(Cohen\sd=0.58,p=0.002)。此外,与食物相关的Go/NoGo任务,pBED组在无效试验中的抑制成功率较低(Cohen'sd=0.47,p=0.012).ERP数据显示,与HC相比,pBED组在与食物相关的Go/NoGo任务的no-go试验中表现出增加的P300潜伏期(FC1,FC2,F3,F4,FZ)(Cohen'sd0.56-0.73,均p<0.05)。
■这些研究结果表明,暴饮暴食的个体在非特异性和食物相关的抑制控制方面都可能受损,与食物相关的抑制控制的损害可能与P300异常有关,暗示与BED有关的行为神经生物学功能障碍机制。
UNASSIGNED: Similar to addictive disorders, deficits on cognitive control might be involved in the onset and development of Binge Eating Disorder (BED). However, it remains unclear whether general or food-related inhibitory control impairments would be basically linked to overeating and binge eating behaviors. This study thus aimed to investigate behavioral performance and electrophysiological correlates of food-related inhibitory control among individuals with binge eating behavior.
UNASSIGNED: Sixty individuals with probable BED (pBED) and 60 well-matched healthy controls (HCs) were assessed using the typical Stop-Signal Task, a revised Go/No Go Task, and a food-related Go/No Go Task. Besides, another separate sample, including 35 individuals with pBED and 35 HCs, completed the food-related Go/No Go Task when EEG signals were recorded with the event-related potentials (ERPs).
UNASSIGNED: The data revealed that the pBED group performed worse with a longer SSRT on the Stop-Signal Task compared with HCs (Cohen\'s d = 0.58, p = 0.002). Moreover, on the food-related Go/No Go Task, the pBED group had a lower success rate of inhibition in no-go trials (Cohen\'s d = 0.47, p = 0.012). The ERPs data showed that in comparison with HCs, the pBED group exhibited increased P300 latency (FC1, FC2, F3, F4, FZ) in the no-go trials of the food-related Go/No Go Task (Cohen\'s d 0.56-0.73, all p < 0.05).
UNASSIGNED: These findings suggested that individuals with binge eating could be impaired in both non-specific and food-related inhibitory control aspects, and the impairments in food-related inhibitory control might be linked to P300 abnormalities, implying a behavioral-neurobiological dysfunction mechanism implicated in BED.