目的:这个随机分组的目的,三臂平行,单盲临床试验旨在评估两次访视间接牙髓治疗中臭氧应用的临床和微生物学有效性.
方法:纳入患有深龋病变的下第一磨牙105颗,并随机分配三组进行两次间接牙髓治疗。在没有任何消毒剂的情况下应用处理程序(对照),使用60-s2%的二葡萄糖酸氯己定(CHX)或60-s臭氧应用。在四个不同阶段(初始开挖后,临时恢复前的臭氧/CHX应用,4个月后立即移除临时修复,和最终开挖),牙本质湿度,一致性,和颜色特性被记录以评估组织的临床特征,和标准牙本质样本被收集用于变形链球菌的微生物学分析,乳酸杆菌,以及菌落形成单位的总数。数据采用Mann-WhitneyU检验进行多重比较分析。
结果:剩下的牙本质变得更硬,干燥器,在所有组4个月后变暗。然而,CHX和臭氧应用在统计学上优于对照组(p<0.05)。各组微生物总数逐渐减少。虽然空腔消毒剂的应用提高了抗菌功效(对照,79.11%;CHX,98.39%;臭氧,93.33%),CHX应用表现出比两组更显著的减少(p=0.000)。
结论:两诊间接牙髓治疗对所有研究组都取得了成功的结果。然而,由于改善了治疗成功率,CHX将是方便优选的。
结论:使用腔消毒剂的两次访问间接牙髓疗法是深龋病变的适当替代治疗程序,而不是传统技术。
OBJECTIVE: The aim of this randomized, three-arm parallel, single-blinded clinical trial was to evaluate the clinical and microbiological effectiveness of the ozone application in two-visit indirect pulp therapy.
METHODS: One hundred five lower first molar teeth with deep caries lesion were included and randomly assigned three groups to apply the two-visit indirect pulp therapy. Treatment procedure was applied without any disinfectant (control), with 60-s 2% chlorhexidine digluconate (CHX) or 60-s ozone application. In four different stages (after initial excavation, ozone/CHX application before the temporary restoration, 4 months later immediately after removing temporary restoration, and final excavation), dentin humidity, consistency, and color properties were recorded to evaluate the clinical characteristics of the tissue, and standard dentin samples were collected for the microbiological analysis of mutans streptococci, lactobacilli, and the total number of colony-forming units. The data were analyzed by using Mann-Whitney U test for multiple comparisons.
RESULTS: The remaining dentin became harder, drier, and darker after 4 months in all groups. However, CHX and ozone application were statistically better than the control group (p < 0.05). There was a gradual decrease in the total number of microorganisms in all groups. While cavity disinfectant applications were improved the antibacterial efficacy (control, 79.11%; CHX, 98.39%; ozone, 93.33%), CHX application exhibited a greater significant reduction than both groups (p = 0.000).
CONCLUSIONS: The two-visit indirect pulp therapy yielded successful results for all study groups. However, CHX would be conveniently preferable due to improving the treatment success.
CONCLUSIONS: The two-visit indirect pulp therapy applied with cavity disinfectant is a proper alternative treatment procedure in deep carious lesions, instead of conventional technique.