Resuming the theoretical and historical conceptualization of mindfulness research is of utmost importance if we want to transcend the positivistic and instrumental trend in the present field and to understand better what mindfulness is and how mindfulness works. Based on von Fircks (2023)\'s introduction of Daosim\'s wu wei into Meadian Social Psychology, this commentary continues dialoguing the two different traditions for understanding mindfulness\'s functioning by exploring the systematic principle underlying wu wei. From the systematic perspective, we can distinguish: 1) two focus of meaning in wu wei: (a) not forcing/interfering and (b) the existence of a spontaneously evolving system; 2) two positions a person can take faced with the spontaneous system: (a) as stepping back and not interfering; (b) as actively connecting and cultivating new relations into systems. Based on the two positions, the dynamic emergence of altered I from mindfulness is also approached in two different ways.

Objective:To investigate the clinical features, imaging findings, surgical methods， diagnostic and treatment experience of spontaneous cerebrospinal fluid otorrhoea. Methods:The clinical data of 11 patients with spontaneous cerebrospinal fluid otorrhoea treated surgically at our hospital from May 2018 to May 2023 were retrospectively analyzed. The medical data included medical history, imaging data, leak location, surgical repair method, treatment effect and postoperative follow-up. Results:Among the 11 surgical patients, 4 patients were initially diagnosed with secretory otitis media, 1 was initially diagnosed with purulent otitis media, and 5 patients had a history of meningitis or presented because meningitis as the initial diagnosis. There were 2 cases of cerebrospinal fluid leakage repaired through the ear canal pathway and 9 cases of cerebrospinal fluid leakage repaired through the mastoid pathway. During the operation, leaks were located in the stapes floor plate in 4 cases, sinus meningeal angle in 1 case, posterior cranial fossa combined with middle cranial fossa in 1 case, middle cranial fossa in 4 cases, and labyrinthine segment of the internal auditory canal and facial nerve canal in 1 case. Ten patient was successfully repaired, and another patient developed intracranial hypertension after surgery, with symptoms alleviated by a lateral ventriculoperitoneal shunt. Postoperative follow-up ranged from 6 months to 4 years, and there was no CSF otorrhoea and meningitis recurrence. Conclusion:The incidence of spontaneous cerebrospinal fluid otorrhea is low, the clinical symptoms are atypical, and the rate of delayed diagnosis or missed diagnosis and misdiagnosis is high. Surgery is currently the preferred treatment for spontaneous cerebrospinal fluid otorrhoea, and satisfactory results are usually achieved; During diagnosis and treatment, it is crucial to be vigilant for intracranial hypertension to prevent serious complications and irreversible damage.
目的：探讨自发性脑脊液耳漏的临床特点、影像学表现、手术方法及诊治经验。 方法：回顾性分析2018年5月至2023年5月手术治疗的11例自发性脑脊液耳漏患者的临床资料，包括既往病史，影像学资料、漏口位置、手术修补方法、治疗效果及术后随访情况等。 结果：11例手术患者，其中4例患者首诊为分泌性中耳炎，1例患者首诊为化脓性中耳炎，5例患者既往有脑膜炎病史或因脑膜炎为初次诊断而就诊；经耳道径路修补脑脊液漏2例，经乳突径路修补脑脊液漏9例；术中发现漏口位于镫骨底板4例，窦脑膜角1例，颅后窝合并颅中窝1例，颅中窝4例，内听道底及面神经管迷路段1例；10例患者1次修补成功，另1例患者术后出现颅内高压，最终行侧脑室腹腔分流术后症状解除。术后随访6个月～4年，无脑脊液耳漏及脑膜炎复发。 结论：自发性脑脊液耳漏发病率低，临床症状不典型，延迟诊断或漏诊误诊率高；手术是目前治疗自发性脑脊液耳漏首选方法，通常可以取得满意的效果；诊疗过程中要警惕并重视颅内高压的存在，防止发生严重并发症及不可逆损伤。.

Accurate calculations and precise results are very important for the dissemination of scientific knowledge, whereas the errors of calculation will diminish the academic value of the paper. This discussion focuses on the calculation of thermodynamics and the determination of the spontaneity of adsorption processes in the paper of Ofudje et al. (2023). Ofudje et al. found that the apatite synthesized by chemical method (CHAp) has excellent adsorption properties for cadmium ions, which is an important contribution to the remediation of cadmium pollution. However, the calculation results of standard Gibbs free energy change (ΔGo), standard enthalpy change (ΔHo) and standard entropy change (ΔSo) of the adsorption of Cd2+ onto CHAp surface need to be corrected due to an incorrect calculation. Firstly, the partition coefficient (KD) with a dimension cannot be used for thermodynamic calculation. Secondly, the adsorbent mass (m) described by Ofudje et al. in different Sections is inconsistent, leading to incorrect results of Ko and ΔGo. When the appropriate value of the adsorbent mass is selected and the partition coefficient is converted to the standard adsorption equilibrium constant Ko, the calculated ΔGo is less than zero, which means that the adsorption is spontaneous. This discussion provides the correct calculation method of standard adsorption equilibrium constants and thermodynamic parameters, which can improve the reader\'s judgment and understanding of adsorption spontaneity.

The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required. The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research. In this paper, we have reviewed recent research progress in relation to mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, to help guide the future study of malignant mechanisms and tumor prevention.

Spontaneity and its connections to mental health and wellbeing are a central issue in both theory and practice of psychodrama, and the specialized literature sometimes even associates the presence of pathology to a lack of spontaneity. This paper describes spontaneity in Moreno\'s theory, its assessment, its association with other measures and concepts, and scientific advances in the field. Specifically, we present results obtained with the English and Portuguese-language versions concerning its assessment. The main purpose of this work was to study the spontaneity measure (SAI-R) in a 3 first-order factors version for a Portuguese sample of 439 subjects, divided into two independent samples. The mean age of participants was 25.6 years (SD = 10.2), and ages ranged between 18 and 64 years. Data was collected through an online platform of a Portuguese market research company. The results revealed that the 3-factor model has acceptable validity for items 1 (\"Creative\") and 7 (\"Euphoric\"), confirming the composite reliability, the convergent validity, but not the discriminant validity. Through multi-group analysis, the model proved to be stable. Notwithstanding the need for complementary studies, including clinical samples, the SAI-R is a short and valid instrument in clinical and non-clinical contexts when evaluating spontaneity.

This study shows the results, for the first time, of an glycerol alkaline-acid electrolyzer. Such a configuration allows spontaneous operation, producing energy and hydrogen simultaneously as a result of the utilization of the neutralization and fuel chemical energy. The electroreformer-built with a 20 wt% Pd/C anode and cathode, and a Na+-pretreated Nafion® 117-can simultaneously produce hydrogen and electricity in the low current density region, whereas it operates in electrolysis mode at high current densities. In the spontaneous region, the maximum power densities range from 1.23 mW cm-2 at 30 °C to 11.9 mW cm-2 at 90 °C, with a concomitant H2 flux ranging from 0.0545 STP m-3 m-2 h-1 at 30 °C to 0.201 STP m-3 m-2 h-1 at 90 °C, due to the beneficial effect of the temperature on the performance. Furthermore, over a chronoamperometric test, the electroreformer shows a stable performance over 12 h. As a challenge, proton crossover from the cathode to the anode through the cation exchange Nafion® partially reduces the pH gradient, responsible for the extra electromotive force, thus requiring a less permeable membrane.

Despite the availability of improvisational theater training in different settings, studies that assess its effectiveness as a means for enhancing cognitive training for older adults are scarce. This study examines the influence of short theater improvisation exercises on the cognitive flexibility of cognitively-healthy older adults, and their influence on the four core components of improvisation (i.e., spontaneity, flow, creativity, playfulness). The study also examines the correlation between an improvement in these four key agents and an improvement in cognitive flexibility among older adults. This quantitative empirical study was conducted in retirement homes and daycare centers in Israel. A total of 45 participants took part in this study, all in good physical health and with age-appropriate cognitive abilities. The participants were divided into five research groups; each group met twice a week for a one-hour improvisation session over a six-week period. The data was collected through five questionnaires that were completed at four points of time (before, during, and after the workshop). The findings did not indicate a significant effect of the improvisation exercises on the participants\' cognitive flexibility, yet they did show improvement in three components of improvisation: spontaneity, flow, playfulness. As such, the findings of this study indicate that despite a normal decline in basic cognitive functioning among older adults, the beneficial effect of improvisation on cognitive flexibility might still occur through spontaneity, playfulness, and flow. In conclusion, short theater improvisation exercises could contribute to various indicators of healthy aging in various settings.

Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water to ingest the dosage form. Furthermore, coprecipitated-dispersed mixtures of vardenafil and three sweeteners (sorbitol, acesulfame K, and sucralose) were prepared and characterized using FTIR, DSC, and solubility studies. Moreover, eight different vardenafil ODFs were prepared using the solvent-casting method. Modified gustatory sensation test, in vitro disintegration, and release studies were performed. In addition, the optimized ODF (F8) was compared with the commercial film-coated tablets pharmacokinetically (relative bioavailability, onset, and duration of actions were estimated). The results indicated that the three sweetening agents had comparable solubilizing capacity. However, both sucralose- and acesulfame K-based ODFs have a more enhanced sweet and palatable taste than sorbitol-sweetened ODF. The SA- and PVP K30-based ODFs showed significantly faster disintegration times and release rates than MC. In conclusion, PVA has good film-forming properties, but a higher ratio of PVA adversely affected the disintegration and release characteristics. The % relative bioavailability for ODF was 126.5%, with a superior absorption rate constant (Ka) of 1.2-fold. The Cmax and estimated Tmax were compared to conventional film-coated tablets.

Struvite precipitation from Wastewater involves an excess of ammonium to create a supersaturated initial solution. The remaining fraction can be a threat to the environment. This work combined struvite precipitation and ammonium sorption using natural zeolite to decrease the ammonium level in the effluent. Two approaches of estimation of feed sample doses were used. One consisted of gradient experiments for ammonium precipitation to the asymptotic level and was combined with clinoptilolite to lower the ammonium level in the effluent. This approach used doses of 0.05:1.51:0.61:1 of Ca:Mg:NH4+:PO43- mole ratios, respectively. In contrast, three level design with narrowed NH4+:PO43- range reached 0.25:1.51:0.8:1 for Ca:Mg:NH4+:PO43- mole ratios. The addition of zeolite decreased effluent ammonium concentration. In both ways, the P and N recoveries were higher than 94% and 72%, respectively. The complexity of the precipitation mixture decreased the ammonium sorption capacity (Qe) of clinoptilolite from Qe of 0.52 to 0.10 meq∙g-1 in single and complex solutions, respectively. Thermodynamically, the addition of 1.5 % of clinoptilolite changed the struvite precipitation spontaneity from ∆G of -5.87 to -5.42 kJ·mol-1 and from 9.66 to 9.56 kJ·mol-1 for gradient and three level experimental procedures, respectively. Thus, clinoptilolite demonstrated a positive effect on the struvite precipitation process and its environmental impact.

Naturalistic developmental behavioral interventions (NDBI) have been shown to facilitate the development of spontaneous language in individuals with speech and language impairment. Several meta-analyses have reported a small number of studies that utilized naturalistic teaching approaches combined with augmentative and alternative communication (AAC) interventions to develop requesting skills in individuals with autism spectrum disorder (ASD). Therefore, the main purpose of this study was to determine whether a natural language paradigm (NLP) and time delay is effective in expanding vocal and augmented requesting skills in three children with ASD between the ages of 4 and 6 years. A concurrent multiple baseline design across participants was used to evaluate the effectiveness of the intervention. The results of the study demonstrated that the participants were successful in emitting vocal requests when both modalities were available and NLP combined with time delay was effective in increasing spontaneous vocal requests in all participants.