背景和目的:脊柱布氏菌炎和ModicI型改变(MC1)之间的区别包括困难。血液炎症指标(HII),如中性粒细胞与淋巴细胞比率(NLR)和全身炎症聚集指数(AISI)被认为是炎症和感染的指标,具有诊断价值。预后,以及在各种疾病中的预测作用。本研究旨在评估布鲁氏菌脊柱盘炎和MC1在HII方面的差异。材料与方法:本研究纳入了35例布氏杆菌脊柱盘炎患者和37例MC1患者。布鲁氏菌脊柱盘炎和MC1通过微生物学诊断,血清学,和放射诊断工具。HII(NLR,MLR,PLR,NLPR,SII,SIRI,AISI)来自基线全血细胞计数。结果:两组患者年龄(p=0.579)和性别(p=0.092)相似,白细胞(p=0.127),中性粒细胞(p=0.366),淋巴细胞(p=0.090),和单核细胞(p=0.756)评分。布鲁氏杆菌组疼痛持续时间显著降低(p<0.001),较高的CRP和ESR水平(p<0.001),血小板计数(p=0.047)低于MC1组。两组在HII:NLR方面具有相似性(p=0.553),MLR(p=0.294),PLR(p=0.772),NLPR(p=0.115),SII(p=0.798),SIRI(p=0.447),和AISI(p=0.248)。结论:HII增加可用于区分感染性和非感染性疾病,但这在布鲁氏菌病中可能无效。然而,疼痛持续时间,CRP和ESR水平,和血小板计数可能有助于区分布鲁杆菌和MC1。
Background and Objectives: Differentiation between brucella
spondylodiscitis and Modic type I changes (MC1) includes difficulties. Hematological inflammatory indices (HII) such as neutrophil to lymphocyte ratio (NLR) and aggregate index of systemic inflammation (AISI) are suggested as indicators of inflammation and infection and have diagnostic, prognostic, and predictive roles in various diseases. This study aimed to evaluate differences between brucella
spondylodiscitis and MC1 in terms of HII. Materials and Methods: Thirty-five patients with brucella
spondylodiscitis and thirty-seven with MC1 were enrolled in the study. Brucella
spondylodiscitis and MC1 were diagnosed by microbiological, serological, and radiological diagnostic tools. HII (NLR, MLR, PLR, NLPR, SII, SIRI, AISI) were derived from baseline complete blood count. Results: The two groups were similar for age (p = 0.579) and gender (p = 0.092), leukocyte (p = 0.127), neutrophil (p = 0.366), lymphocyte (p = 0.090), and monocyte (p = 0.756) scores. The Brucella
spondylodiscitis group had significantly lower pain duration (p < 0.001), higher CRP and ESR levels (p < 0.001), and lower platelet count (p = 0.047) than the MC1 group. The two groups had similarity in terms of HII: NLR (p = 0.553), MLR (p = 0.294), PLR (p = 0.772), NLPR (p = 0.115), SII (p = 0.798), SIRI (p = 0.447), and AISI (p = 0.248). Conclusions: Increased HII can be used to differentiate infectious and non-infectious conditions, but this may be invalid in brucellosis. However, pain duration, CRP and ESR levels, and platelet count may be useful to distinguish brucella spondylodiscitis from MC1.