■描述经宫颈肌瘤消融术(TFA)治疗有症状子宫肌瘤后受孕的妇女的妊娠结局。
■TFA用于射频能量治疗有症状的子宫肌瘤,根据临床试验方案和欧洲医院的商业用途,联合王国,墨西哥,和美国。包括所有在使用Sonata®系统进行TFA后向医生报告怀孕并同意使用其数据的妇女。
在接受TFA治疗的28名妇女中,有36例怀孕,代表20例分娩。五名女性在消融后怀孕不止一次,四个人被认为是辅助生殖技术(ART)的结果。结果包括8次阴道分娩,12剖腹产,3次治疗性流产,和8例妊娠早期自然流产(4例发生在有复发性妊娠丢失和免疫疾病史的患者中)。目前有五名妇女怀孕,其中两人先前在TFA后交付。没有5分钟Apgar评分<7,所有新生儿体重>2500g。所有分娩均发生在≥37周,除了一次分娩在356/7周。没有子宫破裂或胎盘异常,也没有产后出血或死胎的报告。切除的肌瘤包括透壁,粘膜下,和壁内肌瘤直径达7厘米。
■使用索纳塔系统进行TFA后,足月妊娠结局正常,包括反复流产的妇女和接受ART的妇女。没有出现阿普加得分低的情况,低出生体重,死产,产后出血,或子宫破裂(FAST-EU,NCT01226290;索纳塔,NCT02228174;SAGE,NCT03118037)。(JGYNECOLSURG38:207)。
UNASSIGNED: To describe pregnancy outcomes in women who conceived after undergoing transcervical fibroid ablation (TFA) as treatment for symptomatic uterine fibroids.
UNASSIGNED: TFA was used to treat symptomatic uterine fibroids with radiofrequency energy, both under clinical trial protocol and commercial usage in hospitals in Europe, the United Kingdom, Mexico, and the United States. All women who reported pregnancies to their physicians after undergoing TFA with the Sonata® System and provided consent for use of their data were included.
UNASSIGNED: There have been 36 pregnancies representing 20 deliveries among 28 women who were treated with TFA. Five women conceived more than once postablation, and four conceived as a result of assisted reproductive technology (ART). Outcomes include 8 vaginal deliveries, 12 Cesarean sections, 3 therapeutic abortions, and 8 first trimester spontaneous abortions (four occurring in a patient with a history of recurrent pregnancy loss and an immunologic disorder). Five women are currently pregnant, two of whom previously delivered after TFA. There were no 5-minute Apgar scores <7, and all neonates weighed >2500 g. All deliveries occurred at ≥37 weeks except for one delivery at 35 6/7 weeks. There were no uterine ruptures or abnormal placentation and no reports of postpartum hemorrhage or stillbirths. Ablated fibroids included transmural, submucous, and intramural myomata up to 7 cm in diameter.
UNASSIGNED: Normal pregnancy outcomes at term have occurred after TFA with the Sonata System, including in women with recurrent abortion and in those undergoing ART. There were no instances of low Apgar scores, low birthweight, stillbirth, postpartum hemorrhage, or uterine rupture (FAST-EU, NCT01226290; SONATA, NCT02228174; SAGE, NCT03 118037). (J GYNECOL SURG 38:207).