背景:本研究旨在探讨晚期糖基化终产物(AGEs)血清水平之间的临床相关性。AGEs的可溶性受体(sRAGE),和硫氧还蛋白相互作用蛋白(TXNIP)与2型糖尿病(T2DM)个体的肾脂肪部分(RFF)。
方法:共133例T2DM患者纳入研究。RFF,代表肾脏脂肪水平,使用Dixon磁共振成像(MRI)确定。血清AGEs水平,SRAGE,TXNIP,和其他生化指标在禁食的患者中进行了测量。
结果:T2DM患者的RFF与空腹C肽(CP)水平呈正相关,甘油三酯(TG),AGEs,TXNIP,与高密度脂蛋白胆固醇(HDL-c)水平呈负相关(P<0.05)。Pearson相关分析表明,血清AGEs水平,SRAGE,与TXNIP呈正相关(P<0.05)。然后,根据RFF四分位数将所有患者分为4组.HC,CP,TG,AGEs,SRAGE,TXNIP,随着RFF四分位数的增加,DKD百分比趋于增加,HDL-c水平呈下降趋势(p为趋势<0.05)。接下来,以RFF为因变量进行多元线性回归分析.在控制与RFF相关的协变量后,结果表明,血清AGEs和TXNIP水平仍与RFF显着相关。
结论:这些结果表明,循环AGEs和TXNIP水平可能与T2DM患者肾脏中的异位脂肪积累有关,并可作为肾脏脂肪沉积严重程度的指标。
BACKGROUND: This study sought to explore the clinical relevance of the associations of serum levels of advanced glycation end products (AGEs), soluble receptor for AGEs (sRAGE), and thioredoxin-interacting protein (TXNIP) with the renal fat fraction (RFF) in individuals with type 2 diabetes mellitus (T2DM).
METHODS: A total of 133 patients with T2DM were enrolled in the study. RFF, which represents the renal fat level, was determined utilizing Dixon magnetic resonance imaging (MRI). Serum levels of AGEs, sRAGE, TXNIP, and other biochemical parameters were measured in patients who fasted.
RESULTS: RFF in T2DM patients was positively correlated with the fasting levels of C-peptide (CP), triglycerides (TG), AGEs, TXNIP, and sRAGE (P < 0.05) and negatively correlated with the high-density lipoprotein cholesterol (HDL-c) level (P < 0.05). Pearson\'s correlation analysis indicated that the serum levels of AGEs, sRAGE, and TXNIP were interrelated and positively correlated (P < 0.05). Then, all patients were assigned to four groups according to the RFF quartile. The HC, CP, TG, AGEs, sRAGE, TXNIP, and DKD percentages tended to increase as the RFF quartiles increased, while the HDL-c level tended to decrease (p for trend < 0.05). Next, multiple linear regression analysis was performed using RFF as the dependent variable. After controlling for covariates related to RFF, the results showed that the serum levels of AGEs and TXNIP were still significantly correlated with RFF.
CONCLUSIONS: These results suggest that circulating AGEs and TXNIP levels may be associated with ectopic fat accumulation in the kidneys of T2DM patients and may serve as indicators of the severity of renal fat deposition.