背景:以前没有报道描述软组织肉瘤的国家概况。我们使用基于人群的国家癌症登记处的数据检查了日本软组织肉瘤的全国统计数据。
方法:我们确定了23522例软组织肉瘤患者,这些患者在2016-19年期间进入国家癌症注册中心,使用国际疾病分类-肿瘤学,第三版代码癌症的地形和形态学。我们提取了病人的人口统计数据,肿瘤细节(诊断原因,肿瘤位置,组织学,疾病程度),医院容量/类型,治疗,和每个患者的预后。
结果:软组织肉瘤显示有轻微的男性优势。每年约有5500-6000例新病例被诊断为软组织肉瘤,软组织肉瘤的年龄校正发病率为3.22/100000/年。年龄分布在70-79岁年龄段出现单峰,性别分层数据显示,男性的比例更高。最常见的组织学亚型是脂肪肉瘤。最常见的肿瘤部位是软组织和皮肤,然后是腹膜后.疾病程度分为:“局部化”(31.3%),“区域”(38.9%),或“遥远”(10.5%)。我们发现总体生存率和性别之间存在显著关联,年龄,肿瘤位置,设施类型,医院容量,诊断的原因,疾病的程度,和手术治疗。
结论:这是第一项概述流行病学的研究,临床特征,治疗,预后,以及使用国家癌症登记处在日本影响软组织肉瘤预后的重要因素。记录我们关于老年患者结果的数据至关重要,因此其他表现出类似人口老龄化趋势的国家可以从我们的经验中学习。
方法:预后研究,三级。
BACKGROUND: No previous reports have characterized national profiles of soft-tissue sarcoma overall. We examined the nationwide statistics for soft-tissue sarcoma in Japan using data from the population-based National Cancer Registry.
METHODS: We identified 23 522 soft-tissue-sarcoma patients who were entered in the National Cancer Registry during 2016-19 using International Classification of Diseases-Oncology, Third Edition codes for cancer topography and morphology. We extracted data on patient demographics, tumor details (reason for diagnosis, tumor location, histology, extent of disease), hospital volume/type, treatment, and prognosis for each patient.
RESULTS: Soft-tissue sarcoma showed a slight male preponderance. Approximately 5500-6000 new cases were diagnosed as soft-tissue sarcoma per year, with the age-adjusted incidence of soft-tissue sarcoma being 3.22/100000/year. The age distribution showed a single peak in the 70-79 age range, and sex-stratified data showed it was higher in men. The most common histologic subtype was liposarcoma. The most frequent tumor locations were the soft tissue and skin, followed by the retroperitoneum. Extent of disease was categorized as: \"localized\" (31.3%), \"regional\" (38.9%), or \"distant\" (10.5%). We found significant associations between overall survival and sex, age, tumor location, facility type, hospital volume, reason for diagnosis, extent of disease, and surgical treatment.
CONCLUSIONS: This is the first study to outline the epidemiology, clinical features, treatment, prognosis, and significant factors affecting prognosis of soft-tissue sarcoma in Japan using the National Cancer Registry. Documenting our data regarding elderly patients\' outcomes is essential so other countries showing similar population-aging trends can learn from our experiences.
METHODS: Prognostic studies, Level III.