社交焦虑症是一种常见的精神疾病,严重影响个人生活质量,是一种重大的社会负担。尽管社交焦虑存在许多危险因素,目前尚不清楚社会恐惧敏感性在生物学上是如何表现的。此外,因为有些人很有弹性,而另一些人容易受到社会恐惧的影响,重要的是询问支持个人对社会恐惧情况的反应的机制。微生物群-肠道-大脑轴与社会行为有关,最近与社交焦虑症有关,并且可以用作调节的治疗靶标。这里,在社交焦虑障碍的小鼠模型中,我们评估了该轴与社交恐惧灭绝过程相关的潜力。为此,我们将不同的社会恐惧反应与微生物群组成相关联,中心基因表达,和免疫反应。我们的数据提供了证据,表明微生物群的变异性与社交恐惧行为的改变密切相关。此外,我们通过杏仁核转录组学鉴定了与社交恐惧敏感性相关的改变的候选基因.这些包括与社交行为相关的基因(Armcx1,Fam69b,Kcnj9,Maoa,Serinc5、Slc6a17、Spata2和Syngr1),炎症和免疫力(汽车,Ckmt1,Klf5,Maoa,Map3k12,Pex5,Serinc5,Sidt1,Spata2),和微生物-宿主相互作用(Klf5,Map3k12,Serinc5,Sidt1)。一起,这些数据为微生物群-肠-脑轴在社交恐惧反应中的作用提供了进一步的证据.
Social anxiety disorder is a common psychiatric condition that severely affects quality of life of individuals and is a significant societal burden. Although many risk factors for social anxiety exist, it is currently unknown how social fear sensitivity manifests biologically. Furthermore, since some individuals are resilient and others are susceptible to social fear, it is important to interrogate the mechanisms underpinning individual response to social fear situations. The microbiota-gut-brain axis has been associated with social behaviour, has recently been linked with social anxiety disorder, and may serve as a therapeutic target for modulation. Here, we assess the potential of this axis to be linked with social fear extinction processes in a murine model of social anxiety disorder. To this end, we correlated differential social fear responses with microbiota composition, central gene expression, and immune responses. Our data provide evidence that microbiota variability is strongly correlated with alterations in social fear behaviour. Moreover, we identified altered gene candidates by amygdalar transcriptomics that are linked with social fear sensitivity. These include genes associated with social behaviour (Armcx1, Fam69b, Kcnj9, Maoa, Serinc5, Slc6a17, Spata2, and Syngr1), inflammation and immunity (Cars, Ckmt1, Klf5, Maoa, Map3k12, Pex5, Serinc5, Sidt1, Spata2), and microbe-host interaction (Klf5, Map3k12, Serinc5, Sidt1). Together, these data provide further evidence for a role of the microbiota-gut-brain axis in social fear responses.