目的::这项研究使用网络分析来检查反映精神分裂症(SZ)和双相情感障碍(BD)社会功能特定领域之间相互作用的网络结构。
方法:我们使用世界卫生组织残疾评估表2.0(WHODAS2.0)来评估社会功能的六个领域(\'认知\',\'移动性\',\'自我护理\',\'相处\',\'生命活动\',和“参与”)在143例SZ患者中,81例BD患者,106名健康受试者。我们构建了正则化的偏相关网络,估计的网络中心性和边缘强度,测试网络稳定性,并比较了SZ和BD网络结构。
结果:SZ患者的功能障碍水平明显高于BD患者。在我们构建的网络中,“认知”是SZ和BD社会功能的最核心领域。“认知”域主要与SZ网络中的“相处”域和BD网络中的“生活活动”域相关联。我们发现SZ与SZ的网络结构没有显着的组水平差异。BD.
结论:我们的结果表明,认知可能在SZ和BD的社会功能中起关键作用。此外,SZ和BD的社会功能领域具有相似的网络结构,尽管SZ的残疾水平高于BD。
OBJECTIVE: : This study used network analyses to examine network structures reflecting interactions between specific domains of social functioning in schizophrenia (SZ) and bipolar disorder (BD).
METHODS: We used the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) to assess six domains of social functioning (\'cognition\', \'mobility\', \'self-care\', \'getting along\', \'life activities\', and \'participation\') in 143 patients with SZ, 81 patients with BD, and 106 healthy subjects. We constructed regularized partial correlation networks, estimated network centrality and edge strength, tested network stability, and compared SZ and BD network structures.
RESULTS: Patients with SZ showed a significantly higher level of functional disability than patients with BD. In the networks we constructed, \'cognition\' was the most central domain of social functioning in both SZ and BD. The \'cognition\' domain was primarily associated with the \'getting along\' domain in the SZ network and the \'life activities\' domain in the BD network. We found no significant group-level differences in network structures for SZ vs. BD.
CONCLUSIONS: Our results suggest that cognition may play a pivotal role in social functioning in both SZ and BD. In addition, domains of social functioning in SZ and BD have similar network structures despite the higher level of disability in SZ compared to BD.