未经证实:重度抑郁症(MDD)的疗效和预后受到其异质性的限制。具有忧郁特征的MDD是MDD的重要亚型。本研究旨在揭示抑郁症白质(WM)网络的变化。
未经批准:23例首发,未经治疗的忧郁性MDD,59例非忧郁性MDD患者和63例健康对照者接受了扩散张量成像(DTI)扫描。基于图论和支持向量机的WM网络分析用于图像数据分析。
UNASSIGNED:与HC相比,小世界减少,异常节点属性出现在右眶额下回,左眶额上回,右侧尾状核,右眶额上回,右眶中额回,左直肌回,MDD患者的左正中扣带回和副带回。与非忧郁性MDD相比,小世界减少,右眶额下回异常节点属性,左侧眶额上回及右侧尾状核为忧郁型MDD。对于相关性分析,HRSD-17(工作和兴趣)的第7项得分与右眶额下回的节间中心性(aBC)值增加呈正相关,而与左眶额上回的aBC降低呈负相关。SVM分析结果显示,右眶额下回和左眶额上回的异常aBC的准确率最高,为81.0%(69/83),灵敏度为66.3%,区分有或没有忧郁特征的MDD患者的特异性为85.2%。
UNASSIGNED:有和没有忧郁特征的MDD患者之间的WM网络变化存在显着差异。
UNASSIGNED: The efficacy and prognosis of major depressive disorder (MDD) are limited by its heterogeneity. MDD with melancholic features is an important subtype of MDD. The present study aimed to reveal the white matter (WM) network changes in melancholic depression.
UNASSIGNED: Twenty-three first-onset, untreated melancholic MDD, 59 non-melancholic MDD patients and 63 health controls underwent diffusion tensor imaging (DTI) scans. WM network analysis based on graph theory and support vector machine (SVM) were used for image data analysis.
UNASSIGNED: Compared with HC, small-worldness was reduced and abnormal node attributes were in the right orbital inferior frontal gyrus, left orbital superior frontal gyrus, right caudate nucleus, right orbital superior frontal gyrus, right orbital middle frontal gyrus, left rectus gyrus, and left median cingulate and paracingulate gyrus of MDD patients. Compared with non-melancholic MDD, small-worldness was reduced and abnormal node attributes were in right orbital inferior frontal gyrus, left orbital superior frontal gyrus and right caudate nucleus of melancholic MDD. For correlation analysis, the 7th item score of the HRSD-17 (work and interest) was positively associated with increased node betweenness centrality (aBC) values in right orbital inferior frontal gyrus, while negatively associated with the decreased aBC in left orbital superior frontal gyrus. SVM analysis results showed that abnormal aBC in right orbital inferior frontal gyrus and left orbital superior frontal gyrus showed the highest accuracy of 81.0% (69/83), the sensitivity of 66.3%, and specificity of 85.2% for discriminating MDD patients with or without melancholic features.
UNASSIGNED: There is a significant difference in WM network changes between MDD patients with and without melancholic features.