目的:粘膜黑色素瘤(MM)是一种罕见的,头部和颈部区域的侵袭性肿瘤,主要影响鼻腔和上颌窦。本研究探讨了PRAMEIHC染色与鼻窦MM临床病理因素和生存结局的相关性。
方法:回顾性队列包括2011年1月至2022年5月诊断为黑色素瘤的患者。组织病理学重新评估确认MM亚型(上皮样或纺锤体)。IHC检测涉及S100,MelanA,HMB45,SOX10,PRAME,BRAFV600E,和泛TRK。Kaplan-Meier和Cox比例风险分析探讨了生存概率和结果。
结果:该队列包括30名患者(17名女性,13名男性),平均年龄65岁(标准差13)。5年生存率约为32%。Cox分析显示,在≥70%的细胞中,男性和PRAMEIHC染色与较低的生存概率相关。
结论:在鼻窦MM中,≥70%细胞的PRAMEIHC染色与显着较低的生存概率相关。男性,pN1级,肿瘤在鼻窦的位置也预示着较差的生存结果.这些发现强调了MM中PRAME表达和其他临床病理因素的潜在预后意义。需要进一步的研究来验证和扩展这些观察结果。
OBJECTIVE: Mucosal melanoma (MM) is a rare, aggressive neoplasm in the head and neck region, primarily affecting the nasal cavity and maxillary sinus. This study investigates the correlation of PRAME IHC staining with clinicopathological factors and survival outcomes in sinonasal MM.
METHODS: The retrospective cohort included patients diagnosed with melanoma from January 2011 to May 2022. Histopathological reassessment confirmed MM subtype (epithelioid or spindle). IHC testing involved S100, MelanA, HMB45, SOX10, PRAME, BRAF V600E, and pan-TRK. Kaplan-Meier and Cox proportional hazards analyses explored survival probabilities and outcomes.
RESULTS: The cohort comprised 30 patients (17 females, 13 males) with a mean age of 65 years (standard deviation 13). The 5-year survival probability was approximately 32%. Cox analysis revealed male sex and PRAME IHC staining in ≥70% of cells as associated with lower survival probability.
CONCLUSIONS: In sinonasal MM, PRAME IHC staining in ≥70% of cells is associated with significantly lower survival probability. Male sex, pN1 stage, and tumor location in the sinus are also predictive of poorer survival outcomes. These findings highlight the potential prognostic significance of PRAME expression and other clinicopathological factors in MM. Further studies are warranted to validate and expand upon these observations.