背景:主动脉直径与年龄有关,性别,和身体大小。关于高血压对主动脉直径的运动反应(HRE)的长期后遗症的数据很少。在这项回顾性队列研究中,我们旨在评估HRE患者主动脉生长率之间的关系.
方法:我们的分析包括2009年1月至2014年12月招募的649例HRE患者的随访数据。排除已知结缔组织疾病或急性主动脉综合征病史的参与者。通过经胸超声心动图测量Valsalva窦(SoV)和升主动脉(AscAo)的直径,在舒张末期使用前缘到前缘形成。
结果:在基线时,中位年龄,最大收缩压(BP),体重指数(BMI),SoV的直径,AscAo才62岁,208mmHg,26.9kg/m2,35mm,和35毫米分别。32%的患者为女性,67%有高血压。经过7.1年的中位随访,SoV和AscAo的平均年增长率(±SD)分别为0.09(0.41)mm和0.13(0.56)mm。在主动脉直径的增长率与最大收缩压和舒张压之间,或仅考虑基线直径>40mm的个体时,未观察到显着关联。
结论:在这项大型队列研究中,运动期间的最大收缩压和舒张压与主动脉直径的增长率无关.此外,该人群主动脉直径的平均增长率与正常人群的增长率一致.
Aortic diameters are related to age, sex, and body size. There is a scarcity of data on the long-term sequelae of a hypertensive response to exercise (HRE) on aortic diameters. In this retrospective cohort study, we aimed to evaluate the relationship between the growth rates of the aorta in individuals with a HRE.
Our analysis included follow-up data of 649 patients recruited between January 2009 and December 2014 with a HRE. Participants with known connective tissue disease or a history of acute aortic syndrome were excluded. Sinus of Valsalva (SoV) and ascending aorta (AscAo) diameters were measured by transthoracic echocardiography using leading edge to leading edge convention at end-diastole.
At baseline, median age, maximum systolic blood pressure (BP), body mass index (BMI), diameter of the SoV, and AscAo were 62 years, 208 mm Hg, 26.9 kg/m2, 35 mm, and 35 mm respectively. 32% of patients were female and 67% had hypertension. After a median follow-up of 7.1 years, mean yearly growth rates (±SD) of the SoV and AscAo were 0.09 (0.41) mm and 0.13 (0.56) mm, respectively. No significant associations were observed between growth rates of aortic diameters and maximum systolic and diastolic BP or when considering only individuals with a baseline diameter >40 mm.
In this large cohort study, maximum systolic and diastolic BP during exercise showed no association with growth rates of aortic diameters. Furthermore, the mean growth rates of aortic diameters in this population were in line with growth rates in a normal population.