目的:颗粒牛骨替代物(BS)通常用于口腔再生。然而,需要更多的文献集中在各种颗粒牛BS之间的比较分析。本研究评估了不同颗粒牛BS在口腔再生中的临床前和临床数据。
方法:通过筛选PubMed数据库进行了叙述性综述,该综述中包括直到2024年的临床前和临床研究,比较了至少两种不同的颗粒牛BS。除了检查有关制造和处理过程的一般数据外,生物安全,物理和化学特性,和移植物吸收,特别强调评估与山脊保存相关的临床前和临床数据,窦底抬高,种植体周围缺损,以及利用颗粒牛BS的各种形式的牙槽脊增强。
结果:对于被认为具有生物安全性的颗粒牛BS的制造过程,确定了300至1,250°C的各种处理温度和化学清洁步骤的使用。在颗粒牛BS的物理和化学特性中观察到显着的异质性,具有最小或可忽略的移植物吸收。颗粒和孔径以及颗粒牛BS的孔隙率变化明显。临床前评估注意到,对于经受较高处理温度的颗粒牛BS,朝向有利结果的边际倾向。然而,临床数据不足。没有观察到关于山脊保存的区别,虽然高温处理的颗粒牛BS在窦底抬高中略有优势。
结论:在各种颗粒牛BS中观察到临床前和临床结果的细微差异。由于数据不足,与各种颗粒牛BS相关的许多考虑因素,包括种植体周围的缺损,必须更具决定性。更多的临床研究必须有效地解决这些知识差距。
OBJECTIVE: Particulate bovine bone substitutes (BS) are commonly used in oral regeneration. However, more literature is needed focusing on comparative analyses among various particulate bovine BS. This study evaluates pre-clinical and clinical data of different particulate bovine BS in oral regeneration.
METHODS: A narrative review was conducted by screening the PubMed database Included in the review were pre-clinical and clinical studies until 2024 comparing a minimum of two distinct particulate bovine BS. In addition to examining general data concerning manufacturing and treatment processes, biological safety, physical and chemical characteristics, and graft resorption, particular emphasis was placed on assessing pre-clinical and clinical data related to ridge preservation, sinus floor elevation, peri-implant defects, and various forms of alveolar ridge augmentation utilizing particulate bovine BS.
RESULTS: Various treatment temperatures ranging from 300 to 1,250 °C and the employment of chemical cleaning steps were identified for the manufacturing process of particulate bovine BS deemed to possess biosecurity. A notable heterogeneity was observed in the physical and chemical characteristics of particulate bovine BS, with minimal or negligible graft resorption. Variations were evident in particle and pore sizes and the porosity of particulate bovine BS. Pre-clinical assessments noted a marginal inclination towards favorable outcomes for particulate bovine BS subjected to higher treatment temperatures. However, clinical data are insufficient. No distinctions were observed regarding ridge preservation, while slight advantages were noted for high-temperature treated particulate bovine BS in sinus floor elevation.
CONCLUSIONS: Subtle variances in both pre-clinical and clinical outcomes were observed in across various particulate bovine BS. Due to inadequate data, numerous considerations related to diverse particulate bovine BS, including peri-implant defects, must be more conclusive. Additional clinical studies are imperative to address these knowledge gaps effectively.