目的:鼻癌是罕见的,通常诊断为晚期。有些患者无法接受治愈性治疗,只能接受姑息性放疗。我们旨在确定生存的预后因素,以促进该组的治疗个性化。
方法:对12例局部晚期鼻窦癌姑息性放疗患者的生存情况进行回顾性分析。评估了包括年龄在内的十个特征,性别,Karnofsky绩效得分(KPS),放疗前血红蛋白,肿瘤部位,淋巴结受累,组织学,2Gy-分数的等效剂量,完成放疗和同步化疗。
结果:关于单变量分析,KPS≥70(p<0.001)和完成放疗(p<0.001)与更好的生存率显著相关。化疗呈趋势(p=0.097)。在多变量分析中,KPS≥70是显著的(p=0.025),与完成放疗呈趋势(p=0.080)。
结论:KPS是鼻癌姑息性放疗生存的独立预测因子。患者需要密切监测和护理副作用,因为完成放疗对生存很重要。
OBJECTIVE: Sino-nasal cancer is rare and often diagnosed at advanced stages. Some patients cannot receive curative treatment and are treated with palliative irradiation. We aimed to identify prognostic factors for survival to facilitate treatment personalization for this group.
METHODS: Twelve patients treated with palliative radiotherapy for locally advanced sino-nasal cancer were retrospectively analyzed for survival. Ten characteristics were evaluated including age, gender, Karnofsky performance score (KPS), pre-radiotherapy hemoglobin, tumor site, lymph node involvement, histology, equivalent dose in 2 Gy-fractions, completion of radiotherapy and concurrent chemotherapy.
RESULTS: On univariate analysis, KPS ≥70 (p<0.001) and completion of radiotherapy (p<0.001) were significantly associated with better survival. Chemotherapy showed a trend (p=0.097). In the multivariate analysis, KPS ≥70 was significant (p=0.025), and completion of radiotherapy showed a trend (p=0.080).
CONCLUSIONS: KPS is an independent predictor of survival for palliative irradiation of sino-nasal cancer. Patients require close monitoring and care for side effects, since completion of radiotherapy is important for survival.