从蒙古蒿的整个植物中分离出12个未描述的倍半萜内酯和7个已知的倍半萜内酯。根据NMR的解释阐明了它们的结构,HRESIMS,和电子圆二色性(ECD)数据。蒙古内酯A(1)的绝对构型,蒙古内酯C(3),1R,3S-二羟基-7S,11R-germacra-4Z.9Z-dien-12,6S-olide(5),野马内酯E(9),野马内酯F(10),用单晶X-射线晶体学方法测定并测定野马内酯G(11)。首次报道了阿塔贝素内酯E(15)的X射线晶体结构。此外,β-B(13)显示出中等的抗炎活性和显著的抗肿瘤活性,蒿酰胺E(18)显示中等的抗肿瘤活性。
Twelve undescribed sesquiterpene lactones and seven known sesquiterpene lactones were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data. The absolute configurations of mongolicolide A (1), mongolicolide C (3), 1R, 3S-Dihydroxy-7S, 11R-germacra-4Z.9Z-dien-12, 6S-olide (5), indicumolide E (9), indicumolide F (10), and indicumolide G (11) were determined by single-crystal X-ray crystallography. The X-ray crystal structure of artabsinolide E (15) was reported for the first time. In addition, beibersteneolide-B (13) showed moderate anti-inflammatory activity and marked antitumor activity, artemyriantholide E (18) show moderate antitumor activity.