■冠心病(CHD)患者的支架需要长期抗血小板治疗,因为支架血栓形成的可能性很高。正是在这种背景下,Cobra和CataniaPolyzene-F(PzF)支架均设计用于减少支架血栓形成(ST)的发生。在这项研究中,我们综述了PzF纳米涂层支架的安全性和有效性.
■该带有标题的系统综述已在PROSPERO(编号398781)中注册。纳入标准包括PzF纳米涂层冠状动脉支架患者的研究,并报告目标血管衰竭(TVF)和ST作为结果,排除标准是排除无法接受辅助药物治疗或没有必要终点的报告患者.有关PzF纳米涂层支架的报告在PubMed中进行了搜索,Embase,和WebofScience和其他来源。由于存在很少的报告和缺乏比较组,在R软件(v3.6.2)中进行了单臂荟萃分析,使用随机效应模型和通用逆方差方法。经过异质性测试,采用GRADE软件进行证据质量评价。进行漏斗图Egger测试以评估发表偏倚,并进行了敏感性分析,以确定总体效果的稳健性。
■纳入了1,768名受试者的6项研究。合并TVF率的主要终点为8.9%(95%CI7.5%-10.2%),其中包括合并心脏死亡(CD)率(1.5%,95%CI0%-3%),心肌梗死(MI)率(2.7%,95%CI0.4%-5.1%),靶血管血运重建(TVR)(4.8%,95%CI2.4%-7.2%),或靶病变血运重建(TLR)(5.2%,95%CI4.2%-6.4%),而次要终点ST为0.4%(95%CI0.1%-0.9%)。TVF的漏斗图,CD,TVR,TLR没有表现出任何严重的发表偏倚,和TVF,TVR,TLR在等级评估中显示出中等质量的证据。敏感性分析表明,TVF,TLR,和ST表现出良好的稳定性(I2=26.9%,16.4%,和35.5%,分别),而其他终点显示中度不稳定。
■这些数据表明,Cobra和Catania系统的PzF纳米涂层冠状动脉支架在临床应用中表现出良好的安全性和有效性。然而,纳入报告的患者样本量相对较小,如果将来有更多的研究发表,这项荟萃分析将会更新。
■https://www.crd.约克。AC.英国/PROSPERO/,标识符:CRD42023398781。
UNASSIGNED: A stent for patients with coronary heart disease (CHD) provides a requirement for a long-term antiplatelet therapy because of the high possibility of the development of stent thrombosis. It was against this background that both Cobra and Catania Polyzene-F (PzF) stents were designed to reduce the occurrence of stent thrombosis (ST). In this study, we review the safety and effectiveness of a PzF-nanocoated stent.
UNASSIGNED: This systematic review with the title was registered in PROSPERO (No.398781). The inclusion criteria were including studies among patients with PzF-nanocoated coronary stents and reported target vessel failure (TVF) and ST as the outcomes, and the exclusion criteria were excluding reported patients who could not receive the adjunctive medical therapies or without the necessary endpoints. Reports about PzF-nanocoated stents were searched in PubMed, Embase, and Web of Science and other sources. Because of the existence of few reports and a lack of comparison groups, a single-arm meta-analysis was conducted in R software (v3.6.2), using a random-effects model with the generic inverse variance method. After a heterogeneity test, assessment of evidence quality was conducted by using GRADE software. A funnel plot Egger\'s test was performed to evaluate publication bias, and a sensitivity analysis was done to determine the robustness of the overall effects.
UNASSIGNED: Six studies of 1,768 subjects were included. The primary endpoint that pooled the TVF rate was 8.9% (95% CI 7.5%-10.2%), which comprised the pooled cardiac death (CD) rate (1.5%, 95% CI 0%-3%), myocardial infarction (MI) rate (2.7%, 95% CI 0.4%-5.1%), target vessel revascularization (TVR) (4.8%, 95% CI 2.4%-7.2%), or target lesion revascularization (TLR) (5.2%, 95% CI 4.2%-6.4%), while the secondary endpoint ST was 0.4% (95% CI 0.1%-0.9%). The funnel plots of TVF, CD, TVR, and TLR did not show any serious publication bias, and TVF, TVR, and TLR showed evidence of moderate quality in GRADE assessment. The sensitivity analysis showed that TVF, TLR, and ST exhibited good stability (I 2 = 26.9%, 16.4%, and 35.5%, respectively), while the other endpoints showed moderate instability.
UNASSIGNED: These data indicated that the PzF-nanocoated coronary stents of the Cobra and Catania systems demonstrated good safety and efficacy in clinical application. However, the sample size of patients included in the reports was relatively small, and this meta-analysis will be updated if more studies are published in the future.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023398781.