背景本研究旨在评估不同放射治疗方案对有症状骨转移患者的疗效。方法通过将来自不同原发癌的症状性骨转移患者分为三组进行回顾性研究。即,武器A,B,和C.在每个手臂中递送的辐射剂量如下:A手臂的单个部分中的8灰色(Gy),对于B组,五个部分中的20Gy,每个部分的比率为4Gy,和30Gy在10个部分中,每个部分的比率为3Gy。每臂由15名患者组成。根据视觉模拟量表(VAS)对所有三个臂进行比较,以评估疼痛缓解情况。基于东部肿瘤协作组(ECOG)的绩效评分改善,和根据世界卫生组织(WHO)阶梯在一周内的镇痛需求,一个月,还有三个月.结果使用VAS测量三个不同手臂的疼痛缓解情况,即,A臂,B,C.一周后,疼痛缓解率为66.67%,60%,60%,分别。一个月后,在所有三个武器中,这一比例为73.33%。三个月后,是80%,86.67%,和86.67%,分别。该研究还测量了ECOG绩效得分的改善。一周后所有三个臂的改善为60%,一个月后A臂的改善为66.67%,B和C臂的改善为73.33%。三个月后,改善为73.33%,80%,80%的武器A,B,C,分别。在所有三个臂中也测量了镇痛剂使用的减少。一周后,在所有三个武器中都是60%。一个月后,是66.67%,73.33%,武器A占73.33%,B,C,分别。三个月后,是73.33%,80%,80%的武器A,B,C,分别。在三个臂之间没有发现显著的统计学差异。结论单8Gy组的疗效在疼痛和表现评分的改善以及在短期随访中减少镇痛药的使用方面几乎与多分割方案的其他组相当。对于高容量的癌症中心和有经济限制的患者,单部分方案可有效缓解疼痛性骨转移。
Background This study aimed to assess the efficacy of different radiation therapy regimens in treating patients with symptomatic bone metastases. Methodology A retrospective study was conducted by assigning patients with symptomatic bone metastases from different primary cancers into three groups, namely, Arms A, B, and C. The radiation dose delivered in each arm was as follows: 8 Gray (Gy) in a single fraction for Arm A, 20 Gy in five fractions at the rate of 4 Gy per fraction for Arm B, and 30 Gy in 10 fractions at the rate of 3 Gy per fraction for Arm C. Each arm consisted of 15 patients. A comparison was conducted across all three arms to evaluate pain relief based on the Visual Analog Scale (VAS), performance score improvement based on the Eastern Cooperative Oncology Group (ECOG), and analgesic requirement based on the World Health Organization (WHO) step ladder at one week, one month, and three months. Results The pain relief was measured using the VAS in three different arms, i.e., Arm A, B, and C. After one week, the pain relief was 66.67%, 60%, and 60%, respectively. After one month, it was 73.33% in all three arms. At three months, it was 80%, 86.67%, and 86.67%, respectively. The study also measured the improvement in the ECOG performance score. The improvement in all three arms was 60% after one week and 66.67% in Arm A and 73.33% in Arms B and C after one month. After three months, the improvement was 73.33%, 80%, and 80% in Arms A, B, and C, respectively. The decrease in analgesic usage was also measured in all three arms. After one week, it was 60% in all three arms. After one month, it was 66.67%, 73.33%, and 73.33% in Arms A, B, and C, respectively. At three months, it was 73.33%, 80%, and 80% in Arms A, B, and C, respectively. No significant statistical difference was found between the three arms. Conclusions The efficacy of a single 8 Gy arm was almost equivalent to that of other arms of multifractionated regimens in terms of improvement in pain and performance score and decreased use of analgesics for a short duration of follow-up. For high-volume cancer centers and patients with economic constraints, a single-fraction regime provides effective palliation for painful bone metastases.