未经证实:幽门螺杆菌(HP)感染被认为是营养和代谢异常的危险因素,血清蛋白是营养和免疫状态的重要标志。尚不清楚HP感染是否会影响血清蛋白水平。
UNASSIGNED:包括从2020年7月至2021年8月接受健康检查的参与者,其中,1485名具有14C-尿素呼气试验(14C-UBT)值≥100分每分钟(dpm)的受试者被定义为HP阳性病例,将4864例14C-UBT值<100dpm的患者定义为HP阴性病例。进行了人体测量,分析所有受试者的血液生化参数。使用χ2检验比较分类变量,使用Student'st检验比较连续变量。采用Logistic回归分析确定HP感染对血清蛋白的影响。
未经批准:年龄,女性的比例,球蛋白水平,总胆固醇水平,HP感染组低密度脂蛋白胆固醇水平明显高于非感染组(P<0.05)。高度,体重,身体质量指数,臀围,白蛋白水平,白蛋白与球蛋白的比率,甘油三酯水平,未感染组的尿酸水平明显高于感染组(P<0.05)。多因素分析显示HP感染与血清白蛋白水平降低的风险显著相关(比值比[OR]=0.809,P=3.51×10-4);HP感染与血清球蛋白水平升高的风险显著相关(模型1:OR=1.257,P=1.39×10-4);HP感染与白蛋白/球蛋白比值降低的风险显著相关(OR=0.775,P=2.30×10)。
未经证实:HP感染与较低的血清白蛋白水平显著相关,球蛋白水平升高,和较低的白蛋白/球蛋白比率。因此,是影响营养代谢的重要因素。
UNASSIGNED: Helicobacter pylori (HP) infection is considered as a risk factor for nutritional and metabolic abnormalities, and serum protein is an important marker of the nutritional and immune status. It is still unknown whether HP infection affects serum protein levels.
UNASSIGNED: The participants who underwent health screening from July 2020 to August 2021 were included, among whom, 1485 subjects with 14C-urea breath test (14C-UBT) values ≥100 disintegrations per minute (dpm) were defined as HP-positive cases, and 4864 cases with 14C-UBT values <100 dpm were defined as HP-negative cases. Anthropometric measurements were taken, and biochemical parameters of the blood were analyzed for all subjects. Categorical variables were compared using the χ2 test and continuous variables using Student\'s t test. Logistic regression analysis was used to determine the effect of HP infection on serum proteins.
UNASSIGNED: Age, the proportion of female, globulin levels, total cholesterol levels, and low-density lipoprotein cholesterol levels were significantly higher in the HP infected group than in the non-infected group (P < 0.05). Height, weight, body mass index, hip circumference, albumin levels, albumin to globulin ratio, triglycerides levels, and uric acid levels were significantly higher in the non-infected group than in the infected group (P < 0.05). Multifactorial analysis revealed that HP infection was significantly associated with the risk of decreased serum albumin levels (odds ratio [OR] = 0.809, P = 3.51×10-4); HP infection was significantly associated with the risk of increased serum globulin levels (model 1: OR = 1.257, P = 1.39× 10-4); and HP infection was significantly associated with the risk of decreased albumin/globulin ratio (OR= 0.775, P = 2.30×10-5).
UNASSIGNED: HP infection was significantly associated with lower serum albumin levels, elevated globulin levels, and lower albumin/globulin ratio. Thus, it is an important factor affecting nutritional metabolism.