带状疱疹(HZ),由于水痘-带状疱疹病毒的重新激活,是一种重大疾病。本研究旨在探讨影响HZ不同部位感觉神经元受累的因素及其与带状疱疹后遗神经痛(PHN)的关系。从电子病历系统中检索到3143例,其中HZ2676例,PHN467例。性别,年龄,发病部位,既往手术史,和合并症使用多因素逻辑回归模型进行分析。结果揭示了年龄之间的相关性,性别,合并症(糖尿病,冠心病,经皮冠状动脉介入治疗[PCI]),和感觉神经元参与HZ。具体来说,年龄较大,女性性别,糖尿病/冠心病等合并症与骶背根神经节(DRG)受累有关,而PCI病史与腰椎DRG受累相关。此外,HZ在不同位置的感觉神经元参与与PHN有关。此外,PHN的独立危险因素包括胸部DRG受累,年龄较大,和合并症(糖尿病,手术史,恶性肿瘤)。防止损坏DRG至关重要,尤其是在有合并症的个体中,通过活动回避和积极治疗,以尽量减少PHN的发生。
Herpes zoster (HZ), resulting from the reactivation of the varicella-zoster virus, is a significant disease. This study aimed to explore the factors influencing sensory neuron involvement in HZ at different locations and its association with postherpetic neuralgia (PHN). A total of 3143 cases were retrieved from an electronic medical record system, including 2676 cases of HZ and 467 cases of PHN. Gender, age, site of onset, past surgical history, and comorbidities were analyzed using a multifactorial logistic regression model. The results revealed correlations between age, gender, comorbidities (diabetes, coronary heart disease, percutaneous coronary intervention [PCI]), and sensory neuron involvement in HZ. Specifically, older age, female gender, and comorbid conditions such as diabetes/coronary heart disease were associated with sacral dorsal root ganglion (DRG) involvement, while PCI history was associated with lumbar DRG involvement. Additionally, sensory neuron involvement at different locations by HZ was linked to PHN. Furthermore, independent risk factors for PHN included thoracic DRG involvement, older age, and comorbidities (diabetes, surgical history, malignancy). It is crucial to prevent damage to the DRG, especially in individuals with comorbidities, through activities avoidance and active treatment, to minimize the occurrence of PHN.