背景:脂溢性皮炎的发病机制涉及皮脂腺的脂质分泌,马拉色菌定殖,和皮肤屏障破坏的炎症反应。这些途径中的每一个都可以通过饮食来调节,肥胖,和营养补充剂。目前的治疗方案只能暂时控制病情;因此,必须认识到可改变的生活方式因素,这些因素可能在确定疾病严重程度中起作用。
目的:本研究旨在总结已发表的关于饮食的证据,营养补充剂,酒精,肥胖,脂溢性皮炎患者的微量营养素,并为进一步研究领域提供有用的见解。
方法:Scopus的文献检索,PubMed,和MEDLINE(Ovid接口)在1993年至2023年之间发表的英文论文于2023年4月16日进行。病例对照研究,队列研究,包括对成年参与者(>14岁)进行的5名或更多受试者的随机对照试验,病例报告,案例系列,由于证据不足,审查文件被排除在外。
结果:共13项研究,8案件控制,3横截面,和2项随机对照试验,包括13,906例患者。脂溢性皮炎与铜显著增加相关,锰,铁,钙,和镁浓度,并显着降低血清锌和维生素D和E的浓度。坚持西方饮食与女性患者发生脂溢性皮炎的风险较高相关,水果摄入量增加与所有患者发生脂溢性皮炎的风险较低相关。益生元Triphala在8周内改善了患者满意度并降低了头皮皮脂水平。大多数研究发现经常饮酒与脂溢性皮炎之间存在关联,但BMI和肥胖与脂溢性皮炎严重程度和患病率之间的关联是混合的.
结论:这篇综述揭示了需要进一步研究的特定有希望的研究领域,包括评估血清锌的介入研究的需要,维生素D,和补充维生素E治疗脂溢性皮炎。西方饮食的负面影响,酒精使用,肥胖,水果消费的好处是众所周知的;然而,为了充分了解它们与脂溢性皮炎的具体关系,需要进一步的队列研究或介入研究.
背景:PROSPEROCRD42023417768;https://tinyurl.com/bdcta893。
BACKGROUND: Pathogenesis of seborrheic dermatitis involves lipid secretion by sebaceous glands, Malassezia colonization, and an inflammatory response with skin barrier disruption. Each of these pathways could be modulated by diet, obesity, and nutritional supplements. Current treatment options provide only temporary control of the condition; thus, it is essential to recognize modifiable lifestyle factors that may play a role in determining disease severity.
OBJECTIVE: This study aimed to summarize published evidence on diet, nutritional supplements, alcohol, obesity, and micronutrients in patients with seborrheic dermatitis and to provide useful insights into areas of further research.
METHODS: A literature search of Scopus, PubMed, and MEDLINE (Ovid interface) for English language papers published between 1993 and 2023 was conducted on April 16, 2023. Case-control studies, cohort studies, and randomized controlled trials with 5 or more subjects conducted on adult participants (>14 years) were included, case reports, case series, and review papers were excluded due to insufficient level of evidence.
RESULTS: A total of 13 studies, 8 case-control, 3 cross-sectional, and 2 randomized controlled trials, involving 13,906 patients were included. Seborrheic dermatitis was correlated with significantly increased copper, manganese, iron, calcium, and magnesium concentrations and significantly lower serum zinc and vitamin D and E concentrations. Adherence to the Western diet was associated with a higher risk for seborrheic dermatitis in female patients and an increased consumption of fruit was associated with a lower risk of seborrheic dermatitis in all patients. The prebiotic Triphala improved patient satisfaction and decreased scalp sebum levels over 8 weeks. Most studies find associations between regular alcohol use and seborrheic dermatitis, but the association between BMI and obesity on seborrheic dermatitis severity and prevalence is mixed.
CONCLUSIONS: This review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for seborrheic dermatitis. The negative consequences of a Western diet, alcohol use, obesity, and the benefits of fruit consumption are well known; however, to fully understand their specific relationships to seborrheic dermatitis, further cohort or interventional studies are needed.
BACKGROUND: PROSPERO CRD42023417768; https://tinyurl.com/bdcta893.