目的:这是对阿立哌唑月桂酯用于精神分裂症的文献的综合综述。这篇综述介绍了背景,证据,以及在当前精神分裂症发展理论的背景下使用阿立哌唑月桂酯治疗精神分裂症的适应症。
结果:精神分裂症是一种慢性精神疾病,目前在美国影响约330万人。其症状,必须存在六个月以上,由杂乱无章的行为和言论组成,理解现实的能力减弱,听到别人听不到的声音,看到别人看不见的东西,妄想,社会承诺减少,动力下降。这些症状中的大多数可以用抗精神病药物治疗。阿立哌唑月桂酯是一种长效肌内注射剂,可作为D2和5-HT1A受体的部分激动剂活性与5-HT2A受体的拮抗剂活性的组合。它可以作为4-,6-,或8周注射,取决于口服剂量。阿立哌唑月桂酯于2015年10月获得FDA批准。
结论:如果不及时治疗,精神分裂症是一种严重的精神疾病。有多种药物可以帮助治疗精神分裂症。一种抗精神病药,月桂酸阿立哌唑,提供长时间注射,优化和提高合规性。已知的副作用包括体重增加,静坐不能,抗精神病药恶性综合征,迟发性运动障碍,和直立性低血压。阿立哌唑月桂酯是FDA批准的药物,可以每月给药,每六周,或每两个月一次,并被证明是安全有效的。
OBJECTIVE: This is a comprehensive review of the literature regarding the use of Aripiprazole lauroxil for schizophrenia. This review presents the background, evidence, and indications for using aripiprazole lauroxil to treat schizophrenia in the context of current theories on the development of schizophrenia.
RESULTS: Schizophrenia is a chronic mental health disorder that currently affects approximately 3.3 million people in the United States. Its symptoms, which must be present for more than six months, are comprised of disorganized behavior and speech, a diminished capacity to comprehend reality, hearing voices unheard by others, seeing things unseen by others, delusions, decreased social commitment, and decreased motivation. The majority of these symptoms can be managed with antipsychotic medication. Aripiprazole lauroxil is a long-acting intramuscular injection that works as a combination of partial agonist activity at D2 and 5-HT1A receptors combined with antagonist activity at 5-HT2A receptors. It can be dosed as a 4-, 6-, or 8-week injection, depending on oral dosage. Aripiprazole lauroxil was FDA approved in October of 2015.
CONCLUSIONS: Schizophrenia is a severe psychiatric disorder if left untreated. There are multiple medications to help treat schizophrenia. One antipsychotic agent, aripiprazole lauroxil, offers long duration injections that optimize and improve compliance. Known side effects include weight gain, akathisia, neuroleptic malignant syndrome, tardive dyskinesia, and orthostatic hypotension. Aripiprazole lauroxil is an FDA-approved drug that can be administered monthly, every six weeks, or every two months and has been shown to be both safe and effective.