目的沿隧道导管的无菌性炎症是与通过中心静脉端口(CVP)输注trabectedin相关的特征性并发症。迄今为止,没有研究根据使用的CVP系统评估无菌性炎症发生率的差异.这项研究评估了两种不同CVP系统之间无菌炎症发生率的差异。方法本研究在东京大学医院进行,Bunkyo-Ku,东京,日本。对2016年4月至2024年2月之间通过颈内静脉使用CVP输注曲贝替丁的患者进行回顾性评估。无菌性炎症的特征是皮肤红斑,肿胀,疼痛,或从CVP输注trabectedin后沿隧道导管硬化,各种感染测试均为阴性。使用两种不同的CVP系统比较了无菌性炎症的发生率:带Celsite端口的Anthron®聚氨酯导管(P-UCelsite;TorayMedical,东京,日本)和DewXEterna(Terumo,东京,日本)。结果21例患者中,12名和9名患者使用P-UCelsite和DewXEterna输注trabectedin,分别。无菌性炎症发生在五名患者中;其中,四个人因为疼痛加重而接受了CVP切除,使trabectedin输液困难。使用P-UCelsite和DewXEterna的患者中有0(0/12)和56%(5/9)发生无菌炎症,分别,使用P-UCelsite的患者的发病率显着降低(P=0.006)。结论与使用DewXEterna的患者相比,使用P-UCelsite的患者无菌性炎症发生率明显降低。
Purpose Sterile inflammation along the tunneled catheter is a characteristic complication associated with trabectedin infusion via a central venous port (CVP). To date, no studies have evaluated the differences in sterile inflammation incidence according to the CVP system used. This study evaluated the differences in sterile inflammation incidence between two different CVP systems. Methods This study was conducted at The University of Tokyo Hospital, Bunkyo-Ku, Tokyo, Japan. Patients with trabectedin infusion using CVP via the internal jugular vein between April 2016 and February 2024 were retrospectively evaluated. Sterile inflammation was characterized as skin erythema, swelling, pain, or induration along the tunneled catheter after infusion of trabectedin from the CVP and negative for various infection tests. The incidence of sterile inflammation was compared using two different CVP systems: Anthron® polyurethane catheter with Celsite port (P-U Celsite; Toray Medical, Tokyo, Japan) and DewX Eterna (Terumo, Tokyo, Japan). Results Of the 21 patients, 12 and nine patients used P-U Celsite and DewX Eterna for trabectedin infusion, respectively. Sterile inflammation occurred in five patients; of these, four underwent CVP removal because of worsened pain, making trabectedin infusion difficult. Sterile inflammation occurred in 0 (0/12) and 56% (5/9) of patients using P-U Celsite and DewX Eterna, respectively, with a significantly lower incidence in patients using P-U Celsite (P = 0.006). Conclusion Sterile inflammation incidence was significantly lower in patients using P-U Celsite compared to those using DewX Eterna.