杂种牙源性肿瘤是散发性的,其中已报道了一种以上牙源性肿瘤组织类型的独特区域。在组织学上模拟唾液腺病理学的腺瘤样牙源性肿瘤(AOT)与钙化上皮牙源性肿瘤(CEOT)样区域的发生是一个不寻常的发现,以前从未在文献中报道过。我们报道了一例32岁女性出现缓慢增长的硬肿胀,影像学表现为上颌切牙齿间区域的梨形放射状病变。组织学上,组织显示出平淡的长方体到鳞片状上皮细胞的巢状和吻合链,显示出核多态性,超色差,和丰富的细胞质,局部具有突出的细胞间桥。多个嗜碱性钙化,淀粉样物质,导管状形成,可见粘液溢出。肿瘤细胞对CK7,CK19,CK8/18和低Ki67,p63的免疫阳性,对S100的免疫阴性表明CEOT与AOT的混合病变。
Hybrid odontogenic tumors are sporadic, where the distinctive areas of more than one odontogenic tumor tissue type have been reported. The occurrence of adenomatoid odontogenic tumor (AOT) with calcifying epithelial odontogenic tumor (CEOT) like areas histologically simulating salivary gland pathology is an unusual finding that has not been previously reported in the literature. We report the case of a 32-year-old female presenting with slow-growing firm swelling, radiographically as a pear-shaped radiolucent lesion in the interdental region of maxillary incisors. Histologically, the tissue showed nests and anastomosing strands of the bland cuboidal to squamoid epithelial cells showing nuclear pleomorphism, hyperchromatism, and abundant cytoplasm with prominent intercellular bridges focally. Multiple basophilic calcifications, amyloid-like material, duct-like formation, and mucinous spillage are seen. Tumor cells showed immunopositivity for CK 7, CK 19, CK 8/18 and low Ki67, p63, and immunonegativity for S100 suggesting of a hybrid lesion of CEOT with AOT.